A multisensory investigation of the functional significance of the “pain matrix”

Mouraux, André; Diukova, Ana; Lee, Michael C.; Wise, Richard G.; Iannetti, Gian Domenico

doi:10.1016/j.neuroimage.2010.09.084

Cited by 473 publications

(447 citation statements)

References 86 publications

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“…Lights in the scanner room were dim. While lying in the scanner, participants received stimuli of four different sensory modalities: nociceptive somatosensory, non-nociceptive somatosensory, auditory, and visual, and all stimuli were delivered to or around the participant's right side (Mouraux et al, 2011). The brain responses elicited by auditory and visual stimuli were not analyzed and, hence, are not reported in the present study.…”

Section: Methodsmentioning

confidence: 99%

“…Defining the ROIs using the conjunction maps was justified by the fact that only models comprising exactly the same voxels can be validly compared using BMS . Importantly, our previous study has shown that, in these three brain structures, nociceptive and non-nociceptive somatosensory stimuli elicit spatially indistinguishable responses (Mouraux et al, 2011). Therefore, the ROIs defined by the conjunction maps included the bulk of the BOLD responses elicited by both types of somatosensory stimuli.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Parallel Processing of Nociceptive and Non-nociceptive Somatosensory Information in the Human Primary and Secondary Somatosensory Cortices: Evidence from Dynamic Causal Modeling of Functional Magnetic Resonance Imaging Data

Liang

Mouraux²,

Iannetti³

2011

Journal of Neuroscience

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Several studies have suggested that, in higher primates, nociceptive somatosensory information is processed in parallel in the primary (S1) and secondary (S2) somatosensory cortices, whereas non-nociceptive somatosensory input is processed serially from S1 to S2. However, evidence suggesting that both nociceptive and non-nociceptive somatosensory inputs are processed in parallel in S1 and S2 also exists. Here, we aimed to clarify whether or not the hierarchical organization of nociceptive and non-nociceptive somatosensory processing in S1 and S2 differs in humans. To address this question, we applied dynamic causal modeling and Bayesian model selection to functional magnetic resonance imaging (fMRI) data collected during the selective stimulation of nociceptive and non-nociceptive somatosensory afferents in humans. This novel approach allowed us to explore how nociceptive and non-nociceptive somatosensory information flows within the somatosensory system. We found that the neural activities elicited by both nociceptive and non-nociceptive somatosensory stimuli are best explained by models in which the fMRI responses in both S1 and S2 depend on direct thalamocortical projections. These observations indicate that, in humans, both nociceptive and non-nociceptive information are processed in parallel in S1 and S2.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Parallel Processing of Nociceptive and Non-nociceptive Somatosensory Information in the Human Primary and Secondary Somatosensory Cortices: Evidence from Dynamic Causal Modeling of Functional Magnetic Resonance Imaging Data

Liang

Mouraux²,

Iannetti³

2011

Journal of Neuroscience

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show abstract

“…It is actually difficult to provide a unique and consensual definition of the ''pain matrix'' since each area belonging to the ''pain matrix'' is not only involved in the perception of pain, but also form an ensemble of interplaying parts that cannot be reduced to a mere cortical and subcortical ''representation'' of pain. Indeed, several studies have shown that the activity of the so-called ''pain matrix'' (1) can be clearly dissociated from the perception of pain intensity [4,[35][36][37][38][39][40][41], (2) is strongly influenced by factors independent of the intensity of the nociceptive stimulus [37,39,42,43], and (3) can be evoked by nonnociceptive and non-painful stimuli [44][45][46][47][48][49]. Importantly, these experimental observations do not question the involvement of the cortical activity in the emergence of pain.…”

Section: Afferent Pathwaysmentioning

confidence: 97%

Nociception and autonomic nervous system

et al. 2013

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The International Association for the Study of Pain (IASP) defines pain as ''an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage''. Pain may also be experienced in absence of noxious stimuli and together with temperature and other bodily feelings constitute the interoception redefined as the sense of the physiological condition of the entire body, not just the viscera. The main characteristic of these feelings is the affective aspect. Emotion, motivation, and consequent behavior connected with these feelings characterize their homeostatic role. This implies an interaction between neural structures involved in pain sensation and autonomic control. The aim of this review is to focus on pain perception, mainly on pain matrix structures' connections with the autonomic nervous system.

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“…While activity in these areas scales parametrically with pain intensity (Derbyshire et al, 1997;Iannetti et al, 2005a), recent studies suggest that little pain matrix activity is nociceptive-specific. Rather, similar activations can be produced by tactile, auditory, and visual stimuli (Mouraux and Iannetti, 2009;Mouraux et al, 2011). The multisensory nature of this network makes it a likely candidate for cross-modal modulation of pain.…”

Section: Introductionmentioning

confidence: 98%

Linking Pain and the Body: Neural Correlates of Visually Induced Analgesia

Longo¹,

Iannetti²,

Mancini³

et al. 2012

J. Neurosci.

132

138

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The visual context of seeing the body can reduce the experience of acute pain, producing a multisensory analgesia. Here we investigated the neural correlates of this "visually induced analgesia" using fMRI. We induced acute pain with an infrared laser while human participants looked either at their stimulated right hand or at another object. Behavioral results confirmed the expected analgesic effect of seeing the body, while fMRI results revealed an associated reduction of laser-induced activity in ipsilateral primary somatosensory cortex (SI) and contralateral operculoinsular cortex during the visual context of seeing the body. We further identified two known cortical networks activated by sensory stimulation: (1) a set of brain areas consistently activated by painful stimuli (the so-called "pain matrix"), and (2) an extensive set of posterior brain areas activated by the visual perception of the body ("visual body network"). Connectivity analyses via psychophysiological interactions revealed that the visual context of seeing the body increased effective connectivity (i.e., functional coupling) between posterior parietal nodes of the visual body network and the purported pain matrix. Increased connectivity with these posterior parietal nodes was seen for several pain-related regions, including somatosensory area SII, anterior and posterior insula, and anterior cingulate cortex. These findings suggest that visually induced analgesia does not involve an overall reduction of the cortical response elicited by laser stimulation, but is consequent to the interplay between the brain's pain network and a posterior network for body perception, resulting in modulation of the experience of pain.

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A multisensory investigation of the functional significance of the “pain matrix”

Cited by 473 publications

References 86 publications

Parallel Processing of Nociceptive and Non-nociceptive Somatosensory Information in the Human Primary and Secondary Somatosensory Cortices: Evidence from Dynamic Causal Modeling of Functional Magnetic Resonance Imaging Data

Parallel Processing of Nociceptive and Non-nociceptive Somatosensory Information in the Human Primary and Secondary Somatosensory Cortices: Evidence from Dynamic Causal Modeling of Functional Magnetic Resonance Imaging Data

Nociception and autonomic nervous system

Linking Pain and the Body: Neural Correlates of Visually Induced Analgesia

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