A Multiscale Spatial Modeling Framework for the Germinal Center Response
Derek P. Mu,
Christopher D. Scharer,
Norbert E. Kaminski
et al.
Abstract:The germinal center response or reaction (GCR) is a hallmark event of adaptive humoral immunity. Unfolding in the B cell follicles of the secondary lymph organs, a GC culminates in the production of high-affinity antibody-secreting plasma cells along with memory B cells. By interacting with follicular dendritic cells (FDC) and T follicular helper (Tfh) cells, GC B cells exhibit complex spatiotemporal dynamics. Driving the B cell dynamics are the intracellular signal transduction and gene regulatory network tha… Show more
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