A multiscale analytical approach to evaluate osseointegration

Palmquist, Anders

doi:10.1007/s10856-018-6068-y

Cited by 29 publications

(26 citation statements)

References 69 publications

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“…The success of a dental implant depends on the maintenance of successful osseointegration and the support of good-quality bone 2,21 . In contrast to natural teeth, which are buffered with periodontium, dental implant transfers the force directly to surrounding alveolar bone under impact.…”

Section: Discussionmentioning

confidence: 99%

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Simulation analysis of impact damage to the bone tissue surrounding a dental implant

Diao¹,

Li²,

Xin³

et al. 2020

Sci Rep

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Dental implant may suffer transient external impacts. To simulate the effect of impact forces on bone damage is very important for evaluation of damage and guiding treatment in clinics. In this study, an animal model was established by inserting an implant into the femoral condyle of New Zealand rabbit. Implant with good osseointegration was loaded with impact force. A three-dimensional finite element model was established based on the data of the animal model. Damage process to bone tissue was simulated with Abaqus 6.13 software combining dynamic mechanical properties of the femur. The characteristics of bone damage were analyzed by comparing the results of animal testing with numerical simulation data. After impact, cortical bone around the implant and trabecular at the bottom of the implant were prone to damage. The degree of damage correlated with the direction of loading and the magnitude of the impact. Lateral loading was most likely performed to damage cancellous bone. The stress wave formed by the impact force can damage the implant-bone interface and periimplant trabeculae. The data from numerical simulations were consistent with data from animal experiments, highlighting the importance of a thorough examination and evaluation based on the patient's medical history.

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Section: Discussionmentioning

confidence: 99%

“…Alveolar bone plays a vital role in the stability of dental implants throughout the process of osseointegration. Therefore, good osseointegration is key to the success of dental implants 1,2 . Normal masticatory and physiological forces can improve the remodeling of alveolar bone, thus maintaining the stability of bone tissue surrounding the implant 3,4 .…”

mentioning

confidence: 99%

Simulation analysis of impact damage to the bone tissue surrounding a dental implant

Diao¹,

Li²,

Xin³

et al. 2020

Sci Rep

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“…Optical microscopy techniques are often used to observe biological tissues, but they consist in analysing two-dimensional sections. To improve such analysis, three-dimensional techniques have been developed such as X-ray μCT [148,149], which allows imaging of woven bone formation at a titanium interface at the microscale [150] for further finite-element analysis at the microscopic level [151].…”

Section: X-ray-based Techniquesmentioning

confidence: 99%

“…Another function of electron tomography is elemental analysis [148], as in [169], which provides elemental mapping of Ca, P, O and Ti at the implant interface. Electron tomography samples can be prepared with the focused ion beam (FIB) method, thus producing thin lamella [148,150].…”

Section: Electron-based Techniquesmentioning

confidence: 99%

Biomechanical behaviours of the bone–implant interface: a review

Gao

Fraulob

Haïat

2019

J. R. Soc. Interface.

163

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In recent decades, cementless implants have been widely used in clinical practice to replace missing organs, to replace damaged or missing bone tissue or to restore joint functionality. However, there remain risks of failure which may have dramatic consequences. The success of an implant depends on its stability, which is determined by the biomechanical properties of the bone–implant interface (BII). The aim of this review article is to provide more insight on the current state of the art concerning the evolution of the biomechanical properties of the BII as a function of the implant's environment. The main characteristics of the BII and the determinants of implant stability are first introduced. Then, the different mechanical methods that have been employed to derive the macroscopic properties of the BII will be described. The experimental multi-modality approaches used to determine the microscopic biomechanical properties of periprosthetic newly formed bone tissue are also reviewed. Eventually, the influence of the implant's properties, in terms of both surface properties and biomaterials, is investigated. A better understanding of the phenomena occurring at the BII will lead to (i) medical devices that help surgeons to determine an implant's stability and (ii) an improvement in the quality of implants.

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“…Nevertheless, not only multiscale but also multimodal analysis of the bone–biomaterials interface needs to be implemented to fully understand bone formation and osseointegration from the macro to the nanoscale. The complexity of the structural organisation of the bone–biomaterial interface has been reviewed by Palmquist and coworkers (Palmquist, ; Shah et al ., ), emphasising the necessity of correlative and complementary imaging and analytical techniques to evaluate osseointegration at relevant hierarchical scales.…”

Section: Bone Regeneration Xct Analysismentioning

confidence: 99%

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Fernández

Witte²,

Tozzi

2019

Journal of Microscopy

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Bone as such displays an intrinsic regenerative potential following fracture; however, this capacity is limited with large bone defects that cannot heal spontaneously. The management of critical‐sized bone defects remains a major clinical and socioeconomic need with osteoregenerative biomaterials constantly under development aiming at promoting and enhancing bone healing. X‐ray computed tomography (XCT) has become a standard and essential tool for quantifying structure–function relationships in bone and biomaterials, facilitating the development of novel bone tissue engineering strategies. This paper presents recent advancements in XCT analysis of biomaterial‐mediated bone regeneration. As a noninvasive and nondestructive technique, XCT allows for qualitative and quantitative evaluation of three‐dimensional (3D) scaffolds and biomaterial microarchitecture, bone growth into the scaffold as well as the 3D characterisation of biomaterial degradation and bone regeneration in vitro and in vivo. Furthermore, in combination with in situ mechanical testing and digital volume correlation (DVC), XCT demonstrated its potential to better understand the bone–biomaterial interactions and local mechanics of bone regeneration during the healing process in relation to the regeneration achieved in vivo, which will likely provide valuable knowledge for the development and optimisation of novel osteoregenerative biomaterials. Lay Description Bone, being a dynamically adaptable material, displays excellent regenerative properties following fracture. However, the self‐healing capacity of bone becomes more difficult with large bone defects. Those defects are common and occur in many clinical situations; hence, biomaterials are mostly used to restore both bone structure and function in the defect site. X‐ray computed tomography (XCT) is a powerful tool to evaluate bone regeneration in critical‐sized defects after the implantation of biomaterials, allowing to an improved understanding of the regeneration process following different bone tissue engineering approaches. This paper focuses on recent advancements in XCT analysis to characterise biomaterial‐mediated bone regeneration in critical‐sized defects. XCT supports three‐dimensional (3D) analysis of biomaterials, scaffolds and regenerated bone microarchitecture, as well as bone ingrowth into the scaffold. As a nondestructive technique, XCT allows for a 3D characterisation of biomaterial degradation and bone regeneration over time. In addition, XCT combined with in situ mechanical experiments and digital volume correlation (DVC) provides a 3D evaluation and quantification of bone–biomaterial interactions and deformation mechanisms during the regeneration process. This remains essential for the development and enhancement of novel biomaterials able to produce bone that is comparable with the native tissue they aim to replace.

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A multiscale analytical approach to evaluate osseointegration

Cited by 29 publications

References 69 publications

Simulation analysis of impact damage to the bone tissue surrounding a dental implant

Simulation analysis of impact damage to the bone tissue surrounding a dental implant

Biomechanical behaviours of the bone–implant interface: a review

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

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