A Multiplex Assay for the Stratification of Patients with Primary Central Nervous System Lymphoma Using Targeted Mass Spectrometry

Waldera-Lupa, Daniel M.; Poschmann, Gereon; Kirchgaessler, Nina; Etemad-Parishanzadeh, Omid; Baberg, Falk; Brocksieper, Mareike; Seidel, Sabine; Kowalski, Thomas E.; Brunn, Anna; Haghikia, Aiden; Gold, Ralf; Stefanski, Anja; Deckert, Martina; Schlegel, Uwe

doi:10.3390/cancers12071732

Cited by 8 publications

(11 citation statements)

References 27 publications

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“…), which could be tested in CSF and vitreous fluid, and IL-10 in the CSF ( 47 ). Other biomarkers tested in CSF include Circulating U2 small nuclear RNA fragments, Tumor cell-free DNA, Neopterin, Osteopontin, sTACI, sBCMA, APRIL,BAFF, VSIG4, GPNMB4, and APOC2 ( 47 – 50 ). Based on the studies of the markers above, we believe the specific markers for PPL would be developed soon.…”

Section: Discussionmentioning

confidence: 99%

Primary Pituitary Lymphoma in Immunocompetent Patients: A Report on Two Case Studies and the Review of Literature

et al. 2021

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Primary pituitary lymphoma (PPL) represents an extremely rare entity. Here, we have reported two recently identified cases of immunocompetent PPL having diffuse large B-cell lymphoma by surgical biopsy. Both patients had hypopituitarism, with one patient developing right ptosis. In both patients, MRI and FDG-PET/CT depicted sellar mass that extended into the cavernous sinus with the right sphenoid also present in one of the patients. No systemic disease was found in these two patients. Surprisingly, we found that both patients had infiltrative lesions in sphenoid sinus mucosa pathologically, but the sphenoid bones that composed the sellar base were visually intact during the biopsy procedure. Chemotherapy was administered to both patients, where one patient achieved remission at the recent follow-up, whereas the other one did not respond to the treatment. The diagnosis of PPL is usually difficult if solely dependent on history, clinical presentation, biochemical indexes, and radiographic findings. We have also updated and reviewed the epidemiologic features, clinical presentations, pathological characteristics, potential mechanisms, therapeutic orientation, and prognostic advances of PPL. A total of 40 cases (including ours and four pediatric patients), histologically diagnosed, were analyzed in terms of clinical presentation, endocrine abnormality, radiological features, pathology, treatment, and follow-up. Hypopituitarism and headache were the most common presentation of PPL, while diabetes insipidus was reported in 13 patients (43.3%). B cell lymphoma was the most common type of pathology, followed by T-cell and NK/T cell. PPL was more invasive in nature at the suprasellar region (72.5%), cavernous sinus (52.5%), and sphenoidal sinus (27.5%) in 29, 21, and 11 patients, respectively. Pediatric patients with PPL seem to be different compared to their adult counterparts in terms of pathogenesis, clinical presentation, and radiological features. The management of PPL usually follows the treatment protocols for PCNSL but has a poor prognosis compared to the pituitary involvement of systemic lymphoma.

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Section: Discussionmentioning

confidence: 99%

Primary Pituitary Lymphoma in Immunocompetent Patients: A Report on Two Case Studies and the Review of Literature

et al. 2021

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“…Both Xu et al and Hu et al found that VISG4 could be used as a prognostic factor and a potential immunotherapeutic target for glioma [ 32 ] and clear cell renal cell carcinoma [ 33 ]. Similarly, Waldera-Lupa et al found that together with other 2 genes, VSIG4 could be a novel biomarker for supporting the diagnosis of primary central nervous system lymphomas [ 34 ]. Tumor-associated macrophage is the prominent component of lung cancer stroma and VSIG4 may play a cancer-promoting effect in lung carcinoma development [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of esophageal squamous cell carcinoma

Liu

et al. 2021

BMC Med Genomics

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Background As a complex system participating in tumor development and progression, the tumor microenvironment was poorly understood in esophageal cancer especially squamous cell carcinoma (ESCC). Methods ESTIMATE algorithm is used to investigate tumor-infiltrating immune cells and prognostic genes which were associated with the tumor microenvironment in ESCC. Results Based on the immune and stromal scores, ESCC samples were divided into high and low score groups and 299 overlapping differentially expressed genes were identified. Functional enrichment analysis showed that these genes were mainly involved in muscle-related function. Prognostic genes including COL9A3, GFRA2, and VSIG4 were used to establish a risk prediction model using Cox regression analyses. Then multivariate analysis showed that COL9A3 was an independent discriminator of a better prognosis. Kaplan–Meier survival analysis showed that the expression of COL9A3 was significantly correlated with the overall survival of ESCC patients. The area under the curve for the risk model in predicting 1- and 3- year survival rates were 0.660 and 0.942, respectively. The risk score was negatively correlated with plasma cells, while positively correlated with the proportions of activated CD4 memory T cells, M1 Macrophages and M2 Macrophages (p < 0.001 for each comparison). Gene set enrichment analysis suggested that both immune response and immune system process gene sets were significantly enriched in high-risk group. Conclusions Our study provided a comprehensive understanding of the TME in ESCC patients. The establishment of the risk model is valuable for the early identification of high-risk patients to facilitate individualized treatment and improve the possibility of immunotherapy response.

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“…Both Xu et al and Hu et al found that VISG4 could be used as a prognostic factor and a potential immunotherapeutic target for glioma [32] and clear cell renal cell carcinoma [33]. Similarly, Waldera-Lupa et al found that together with other 2 genes, VSIG4 could be a novel biomarker for supporting the diagnosis of primary central nervous system lymphomas [34]. Tumorassociated macrophage is the prominent component of lung cancer stroma and VSIG4 may play a cancer-promoting effect in lung carcinoma development [35].…”

Section: Discussionmentioning

confidence: 99%

Profiles of Immune Cell Infiltration and Immune-Related Genes in the Tumor Microenvironment of Esophageal Squamous Cell Carcinoma

Liu

et al. 2020

Preprint

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Backgrounds: As a complex system participating in tumor development and progression, the tumor microenvironment was poorly understood in esophageal cancer especially squamous cell carcinoma (ESCC).Methods: ESTIMATE algorithm is used to investigate tumor-infiltrating immune cells and prognostic genes which were associated with the tumor microenvironment in ESCC. Results: Based on the immune and stromal scores, ESCC samples were divided into high and low score groups and 299 overlapping differentially expressed genes were identified. Functional enrichment analysis showed that these genes were mainly involved in muscle-related function. Prognostic genes including COL9A3, GFRA2, and VSIG4 were used to establish a risk prediction model using Cox regression analyses. Then multivariate analysis showed that COL9A3 was an independent discriminator of a better prognosis. Kaplan-Meier survival analysis showed that the expression of COL9A3 was significantly correlated with the overall survival of ESCC patients. The area under the curve for the risk model in predicting 1- and 3- year survival rates were 0.660 and 0.942, respectively. The risk score was negatively correlated with plasma cells, while positively correlated with the proportions of activated CD4 memory T cells, M1 Macrophages and M2 Macrophages (P<0.001 for each comparison). Gene set enrichment analysis suggested that both immune response and immune system process gene sets were significantly enriched in high-risk group.Conclusions: Our study provided a comprehensive understanding of the TME in ESCC patients. The establishment of the risk model is valuable for the early identification of high-risk patients to facilitate individualized treatment and improve the possibility of immunotherapy response.

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A Multiplex Assay for the Stratification of Patients with Primary Central Nervous System Lymphoma Using Targeted Mass Spectrometry

Cited by 8 publications

References 27 publications

Primary Pituitary Lymphoma in Immunocompetent Patients: A Report on Two Case Studies and the Review of Literature

Primary Pituitary Lymphoma in Immunocompetent Patients: A Report on Two Case Studies and the Review of Literature

Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of esophageal squamous cell carcinoma

Profiles of Immune Cell Infiltration and Immune-Related Genes in the Tumor Microenvironment of Esophageal Squamous Cell Carcinoma

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