“…Shin et al (2005) carried out multi-objective optimization for DNA sequences, including continuity, similarity, hairpin structure, H-measure, and GC content. Because the traditional algorithm cannot address the heterogeneity and conflict of DNA sequences, scientists designed a multi-objective optimization algorithm based on the artificial bee colony (MO-ABC) (Chaves-González et al, 2013), in which six kinds of conflict problems were solved, and finally, a reliable DNA sequence was generated. In 2014, in order to obtain effective DNA sequences, they proposed to use the multi-objective differential evolution algorithm (DEPT) (Chaves-González and Vega-Rodríguez, 2014) to optimize DNA sequences.…”