A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events

Heeney, Matthew M.; Hoppe, Carolyn; Abboud, Miguel R.; Inusa, Baba; Kanter, Julie; Ogutu, Bernhards; Brown, Patricia; Heath, Lori E.; Jakubowski, Joseph A.; Zhou, Chunmei; Zamoryakhin, Dmitry; Agbenyega, Tsiri; Colombatti, Raffaella; Hassab, Hoda; Nduba, Videlis; Oyieko, Janet; Robitaille, Nancy; Segbefia, Catherine; Rees, David C.

doi:10.1056/nejmoa1512021

Cited by 122 publications

(102 citation statements)

References 31 publications

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“…[56][57][58][59][60][61][62][63] Three studies did not use a placebo intervention for their control group. 43,54,56 A majority of studies were performed in North America (n 5 10), 33,46,47,51,61,62,[64][65][66][67][68] Africa (n 5 9), 38,42,52,55,56,59,[69][70][71] and Latin America (n 5 8).…”

Section: Selection Of Articlesmentioning

confidence: 99%

“…40,44,48,49,53,54,57,72 Four studies were performed on multiple continents. 58,60,63,73 The number of patients per study ranged from 9 to 341. A majority of studies were limited to patients with the HbSS or HbSb 0 genotype (n 5 26).…”

Section: Selection Of Articlesmentioning

confidence: 99%

“…A majority of studies were limited to patients with the HbSS or HbSb 0 genotype (n 5 26). 37,38,42,44,45,[48][49][50][51][52][53][54][55][56][57][59][60][61]63,64,66,67,[69][70][71]74 A summary overview of the characteristics, risk of bias, and primary outcomes of the included studies is provided in Table 1. The complete results of our risk-of-bias assessment and a detailed overview of the primary and secondary outcomes of this review per study are provided in supplemental Tables 2 and 3, respectively.…”

Section: Selection Of Articlesmentioning

confidence: 99%

“…Only 7 of the 35 studies scored an overall low risk of bias on all items in the quality assessment. [58][59][60]66,69,72,73 Fourteen studies scored a high risk of bias on at least 1 of the items of the quality assessment, in particular on incomplete outcome data (n 5 8) and blinding of participants (n 5 6) and personnel for intervention (n 5 6). 37,[43][44][45]48,49,51,54,56,63,64,70,71,74 Anticoagulation.…”

Section: Quality Of the Included Studiesmentioning

confidence: 99%

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Pharmacotherapeutical strategies in the prevention of acute, vaso-occlusive pain in sickle cell disease: a systematic review

et al. 2017

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Sickle-cell disease (SCD) is characterized by frequent and painful vaso-occlusive crises (VOCs).Various treatments have been evaluated over the years. However, a clear overview is lacking.The objective of this study was to systematically review all pharmacotherapeutical strategies in the prevention of VOCs beyond hydroxyurea. We performed a systematic literature search (MEDLINE, Embase, CENTRAL). Eligible studies were controlled clinical trials evaluating pharmacotherapeutical interventions targeting the reduction of VOCs in patients with SCD.Primary outcomes were the number or duration of SCD-related pain days, VOCs, or hospital admissions for VOCs. Secondary outcomes included time to first VOC or hospital admission for a VOC. A standardized data extraction sheet was used. The methodological quality of studies was assessed using Cochrane's risk-of-bias tool. A total of 36 studies were included in this review, covering 26 different prophylactic interventions. The most promising interventions for reducing the frequency of either VOCs or hospitalizations were the oral antioxidants L-glutamine and v-3 fatty acids and the IV antiadhesive agent crizanlizumab. Twenty-three studies did not show any beneficial effect of the intervention under investigation, and 6 studies were either too small or methodologically inadequate to draw conclusions. Because of the heterogeneity of interventions, no meta-analysis was performed. In conclusion, this review identified 3 promising pharmacotherapeutical strategies in the prevention of VOCs in SCD. Importantly, this study highlights the discrepancy between the significant burden of SCD worldwide and the low number of adequate trials performed. This review was

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Section: Selection Of Articlesmentioning

confidence: 99%

Section: Selection Of Articlesmentioning

confidence: 99%

Section: Selection Of Articlesmentioning

confidence: 99%

Section: Quality Of the Included Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacotherapeutical strategies in the prevention of acute, vaso-occlusive pain in sickle cell disease: a systematic review

et al. 2017

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“…Heeney et al (5) evaluated the efficacy of prasugrel in reducing the rate of vaso-occlusive crisis in children and adolescents with sickle cell anemia. According to a specific inclusion and exclusion criteria, a total of 341 patients (170 patients Palcepo group, 171 patients Prasugrel group) were enrolled in the study.…”

Section: Ikeoluwa Lagunju Et Al (2015)mentioning

confidence: 99%

Evaluation of the Most Common Complications of Sickle Cell Anemia and Management in Children: Simple Literature Review

Hassan¹,

Mohammad²

2018

The Egyptian Journal of Hospital Medicine

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Background: Sickle cell anemia is an autosomal structural defect that affect the hemoglobin. It is associated with reduction in the RBC life span especially under stress. As a result of this structural defect the RBCs takes a sickle shape which is associated with a lot of complications that significantly have an effect on the patient's life. Objective: In this study, we aim at evaluating the most common complication of sickle cell anemia. Also, the assessment of the various management plans to prevent it if occurred. Methods: PubMed database were used for articles selection as well as all relevant articles to our research interest with the following topics: Sickle cell anemia, Complications, Mortality, Prevention and Management. We excluded other articles, which are not related to this field. The data were extracted according to specific form in which it is going to be reviewed by the group members. Conclusion: Sickle cell anemia have various complications that have impact on quality of life and arise from effect of three main pathophysiological mechanisms i.e. Vasooclussive, hyper-haemolytic and infective complications. Hydroxyurea, chronic blood transfusion, and routine Transcranial Doppler Ultrasound are still the most useful preventive measures of SCA complications.

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Comparison of US Federal and Foundation Funding of Research for Sickle Cell Disease and Cystic Fibrosis and Factors Associated With Research Productivity

et al. 2020

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IMPORTANCE Sickle cell disease (SCD) and cystic fibrosis (CF) are severe autosomal recessive disorders associated with intermittent disease exacerbations that require hospitalizations, progressive chronic organ injury, and substantial premature mortality. Research funding is a limited resource and may contribute to health care disparities, especially for rare diseases that disproportionally affect economically disadvantaged groups. OBJECTIVE To compare disease-specific funding between SCD and CF and the association between funding and research productivity. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study examined federal and foundation funding, publications indexed in PubMed, clinical trials registered in ClinicalTrials.gov, and new drug approvals from January 1, 2008, to December 31, 2018, in an estimated US population of approximately 90 000 individuals with SCD and approximately 30 000 individuals with CF. MAIN OUTCOMES AND MEASURES Federal and foundation funding, publications indexed in PubMed, clinical trial registrations, and new drug approvals.

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A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events

Cited by 122 publications

References 31 publications

Pharmacotherapeutical strategies in the prevention of acute, vaso-occlusive pain in sickle cell disease: a systematic review

Pharmacotherapeutical strategies in the prevention of acute, vaso-occlusive pain in sickle cell disease: a systematic review

Evaluation of the Most Common Complications of Sickle Cell Anemia and Management in Children: Simple Literature Review

Comparison of US Federal and Foundation Funding of Research for Sickle Cell Disease and Cystic Fibrosis and Factors Associated With Research Productivity

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