A Multimodality Review of Adrenal Tumors

Bhargava, Peeyush; Sangster, Guillermo; Haque, Kabiul; Garrett, J. V.; Donato, Maren; D’Agostino, Horacio

doi:10.1067/j.cpradiol.2018.10.002

Cited by 13 publications

(27 citation statements)

References 53 publications

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“…The proliferation index (Ki-67) of the reported patient was estimated as 10-15%. Compared to other cases, the majority of tumours tested for Ki-67 were significantly higher [2,4].…”

mentioning

confidence: 66%

“…Due to the extreme rarity of leiomyosarcomas, they are not considered in differential diagnosis. Moreover, there are other malignant and benign adrenal tumours that might be found, such as non-functioning adenoma, myelolipoma, or adrenal cortical carcinoma, which is the most common malignant neoplasm [4,5]. Therefore, plasma ACTH and cortisol examination together with dexamethasone suppression test are usually performed to confirm or exclude initial diagnosis.…”

mentioning

confidence: 99%

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Leiomyosarcoma in adrenal gland

Dymek

Kiełbowski

Sienkiewicz

et al. 2021

Endokrynologia Polska

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“…The proliferation index (Ki-67) of the reported patient was estimated as 10-15%. Compared to other cases, the majority of tumours tested for Ki-67 were significantly higher [2,4].…”

mentioning

confidence: 66%

mentioning

confidence: 99%

Leiomyosarcoma in adrenal gland

Dymek

Kiełbowski

Sienkiewicz

et al. 2021

Endokrynologia Polska

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“…Adrenal tumors may originate either from the cortex or medulla or be classified as secondary lesions. They can be categorized as benign or malignant, functional (hormone secreting), which can lead to clinical conditions such as Cushing’s syndrome or hyperaldosteronism, or non-functional [ 1 , 2 , 3 , 4 , 5 , 6 ]. The most frequent finding among incidentalomas is non-functional benign adenomas, comprising 80% of cases.…”

Section: Introductionmentioning

confidence: 99%

“…Among the patients with ACC, approximately 50% are asymptomatic or present with symptoms related to mechanical effects of tumor growth. The other half of patients with functional tumors may present with Cushing’s syndrome, virilization, and rarely feminization or hyperaldosteronism [ 5 , 6 , 7 ]. The adrenal surgery for ACC should include a complete en bloc excision with resection of oligometastatic disease.…”

Section: Introductionmentioning

confidence: 99%

Serum Visfatin/NAMPT as a Potential Risk Predictor for Malignancy of Adrenal Tumors

Sawicka‐Gutaj

Komarowska

Gruszczyński

et al. 2022

JCM

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Adrenocortical carcinomas (ACC) are rare endocrine malignancies, often with a poor prognosis. Visfatin/NAMPT regulates a variety of signaling pathway components, and its overexpression has been found in carcinogenesis. Our study aimed to assess the clinical usefulness of visfatin/NAMPT serum level in discriminating between ACC and benign adrenocortical tumors. Twenty-two patients with ACC and twenty-six patients with benign adrenocortical tumors were recruited. Fasting blood samples were collected from each patient, and visfatin serum levels were measured with the ELISA Kit. Clinical stage, tumor size, Ki67 proliferation index, hormonal secretion pattern, and follow-up were determined in ACC patients. Patients with ACC had significantly higher visfatin serum concentrations (7.81 ± 2.25 vs. 6.08 ± 1.32 ng/mL, p-value = 0.003). The most advanced clinical stage with metastases was associated with significantly elevated visfatin levels (p-value = 0.022). Based on ROC analysis, visfatin serum concentrations higher than 8.05 ng/mL could discriminate ACC with a sensitivity of 50.0% and specificity of 92.3%. Univariate Cox regression indicated that tumor size was significantly related to shorter survival, and the visfatin level was borderline significant in all patients (HR = 1.013, p-value = 0.002, HR = 1.321, p-value = 0.058). In the Kaplan-Meier method, patients with visfatin serum concentrations higher than 6.3 ng/mL presented significantly lower survival probability (p-value = 0.006). Serum visfatin/NAMPT could be a potential risk predictor for the malignancy of adrenal tumors. However, further studies are needed on this subject.

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“…With the rapid development of medical technology, imaging has become the examination method for many diseases, which is widely used in the screening of diseases and the diagnosis of tumor diseases. At present, CT and magnetic resonance imaging (MRI) are commonly used in the clinical diagnosis of adrenal tumors [ 5 ]. The location of the adrenal gland and surrounding tissues create good conditions for CT examination.…”

Section: Introductionmentioning

confidence: 99%

Binary Particle Swarm Optimization Intelligent Feature Optimization Algorithm‐Based Magnetic Resonance Image in the Diagnosis of Adrenal Tumor

Tian²,

Wang

et al. 2022

Contrast Media & Molecular Imaging

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This research was aimed to explore the application value of magnetic resonance imaging (MRI) based on binary particle swarm optimization algorithm (BPSO) in the diagnosis of adrenal tumors. 120 patients with adrenal tumors admitted to the hospital were selected and randomly divided into the control group (conventional MRI examination) and the observation group (MRI examination based on the BPSO intelligent feature optimization algorithm), with 60 cases in each group. The sensitivity, specificity, accuracy, and Kappa of the diagnostic methods were compared between the two groups. The results showed that the calculation rate of the BPSO algorithm was the best under the same processing effect ( P < 0.05). Optimization algorithm-based MRI is used in the diagnosis of adrenal tumors, and the results showed that the sensitivity, specificity, accuracy, and Kappa (83.33%, 79.17%, 81.67%, and 0.69) of the observation group were higher than those of the control group (50%, 75%, 58.33%, and 0.45). The similarity of tumor location results in the observation group (89.24%) was significantly higher than that in the control group (65.9%) ( P < 0.05). In conclusion, compared with SFFS and other algorithms, the BPSO algorithm has more advantages in calculation speed. MRI based on the BPSO intelligent feature optimization algorithm has a good diagnostic effect and higher accuracy in adrenal tumors, showing the good development prospects of computer intelligence technology in the field of medicine.

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A Multimodality Review of Adrenal Tumors

Cited by 13 publications

References 53 publications

Leiomyosarcoma in adrenal gland

Leiomyosarcoma in adrenal gland

Serum Visfatin/NAMPT as a Potential Risk Predictor for Malignancy of Adrenal Tumors

Binary Particle Swarm Optimization Intelligent Feature Optimization Algorithm‐Based Magnetic Resonance Image in the Diagnosis of Adrenal Tumor

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