A Multimodality Image Guided Precision Radiation Research Platform: Integrating X-ray, Bioluminescence, and Fluorescence Tomography With Radiation Therapy

Shi, Junwei; Xu, Keying; Keyvanloo, Amir; Udayakumar, Thirupandiyur S.; Ahmad, Anis; Yang, Fei; Yang, Yidong

doi:10.1016/j.ijrobp.2020.06.023

Cited by 11 publications

(20 citation statements)

References 43 publications

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“…It is imperative for us to develop the QBLT to accurately quantify the spatial distribution of the underlying tumor for radiation guidance. Recently, there are several studies showing the potentiality of applying BLT for radiation guidance (13,(19)(20)(21)(22). The significance of this work is that we devised a comprehensive approach to systematically tackle the known challenging of optical tomography for in vivo target delineation, quantify its uncertainties in both biology and tissue optics for localization, and present the practicality for radiation guidance.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the underdetermined nature of BLT, we chose the multi-projection and multi-spectral imaging acquisition to maximize input information for QBLT reconstruction (17,22). Accurate target reconstruction depends on if we have correct surface images as input.…”

Section: Discussionmentioning

confidence: 99%

“…Several recent studies have shown the potential of applying BLT for radiation guidance. 13 , 19 – 22 The significance of this work is that we devised a comprehensive approach to systematically tackle the known challenging of optical tomography for in vivo target delineation, quantify its uncertainties in both biology and tissue optics for localization, and present the practicality for radiation guidance. Through this work, we expect to increase the recognition of BLT and its adoption for biology-guided irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…To bridge this gap and to translate BLT-guided irradiation for practical use by investigators, we present a comprehensive study of achieving quantitative BLT (QBLT) that enables image-guided conformal irradiation based on 3D bioluminescence distribution in vivo. In this work, different from our and other groups’ previous work, 13 , 19 – 22 we made great effort not only optimizing hardware, algorithm, and calibration methods, but also quantifying biologic variation and providing the approach of designing radiation margin for BLT-guided RT.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research

Deng

Dehghani

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research

Deng

Dehghani

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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“…The enhanced absorbed doses in the vicinity of multiple GNPs at the cellular and molecular level require verification that is often provided by MC simulations ( 46–49 ) which more generally should be extended to include chemical effect modelling for radiobiological simulations. A further challenge is to simulate X-ray fluorescence as a new imaging modality for targeted molecular radiotherapy in parallel with experimental developments ( 50 ) .…”

Section: Vision 1: Towards Updated Fundamental Dose Concepts and Quantitiesmentioning

confidence: 99%

Eurados Strategic Research Agenda 2020: Vision for the Dosimetry of Ionising Radiation

Harrison

Ainsbury

Alves

et al. 2021

Radiation Protection Dosimetry

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Since 2012, the European Radiation Dosimetry Group (EURADOS) has developed its Strategic Research Agenda (SRA), which contributes to the identification of future research needs in radiation dosimetry in Europe. Continued scientific developments in this field necessitate regular updates and, consequently, this paper summarises the latest revision of the SRA, with input regarding the state of the art and vision for the future contributed by EURADOS Working Groups and through a stakeholder workshop. Five visions define key issues in dosimetry research that are considered important over at least the next decade. They include scientific objectives and developments in (i) updated fundamental dose concepts and quantities, (ii) improved radiation risk estimates deduced from epidemiological cohorts, (iii) efficient dose assessment for radiological emergencies, (iv) integrated personalised dosimetry in medical applications and (v) improved radiation protection of workers and the public. This SRA will be used as a guideline for future activities of EURADOS Working Groups but can also be used as guidance for research in radiation dosimetry by the wider community. It will also be used as input for a general European research roadmap for radiation protection, following similar previous contributions to the European Joint Programme for the Integration of Radiation Protection Research, under the Horizon 2020 programme (CONCERT). The full version of the SRA is available as a EURADOS report (www.eurados.org).

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A GPU‐accelerated Monte Carlo dose computation engine for small animal radiotherapy

et al. 2023

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BackgroundAccurate dose computation is critical in precision small animal radiotherapy. The Monte Carlo simulation method is the gold standard for radiation dose computation but has not been widely implemented in practice due to its low computation efficiency.PurposeThis study aims to develop a GPU‐accelerated radiation dose engine (GARDEN) based on the Monte Carlo simulation method for fast and accurate dose computation.MethodsIn the GARDEN simulation, Compton scattering, Rayleigh scattering, and photoelectric effect were considered. The Woodcock tracking algorithm and GPU‐specific acceleration techniques were used to obtain a high computational efficiency. Benchmark studies against both Geant4 simulations and experimental measurements were performed for various phantoms and beams. Finally, a conformal arc treatment plan was designed for a lung tumor to further evaluate the accuracy and efficiency in small animal radiotherapy.ResultThe engine attained a speed‐up of 1232 times in a homogeneous water phantom and 935 times in a water‐bone‐lung heterogeneous phantom when compared with Geant4. Both the depth‐dose curves and cross‐sectional dose profiles for various radiation field sizes showed a great match between measurements and the GARDEN calculations. For in vivo dose validation, the differences between calculations and measurements in the mouse thorax and abdomen were 2.50% ± 1.50% and 1.56% ± 1.40%, respectively. The computation time for an arc treatment plan delivered from 36 angles was 2 s at a <1% uncertainty level using an NVIDIA GeForce RTX 2060 SUPER GPU. When compared with Geant4, the 3D gamma comparison passing rate was 98.7% at 2%/0.3 mm criteria.ConclusionGARDEN can perform fast and accurate dose computations in heterogeneous tissue environments and is expected to play a vital role in image‐guided precision small animal radiotherapy.

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A Multimodality Image Guided Precision Radiation Research Platform: Integrating X-ray, Bioluminescence, and Fluorescence Tomography With Radiation Therapy

Cited by 11 publications

References 43 publications

Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research

Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research

Eurados Strategic Research Agenda 2020: Vision for the Dosimetry of Ionising Radiation

A GPU‐accelerated Monte Carlo dose computation engine for small animal radiotherapy

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