2011
DOI: 10.1016/j.jvs.2010.07.067
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A multimodal therapeutic approach to phlegmasia cerulea dolens in a pediatric patient

Abstract: Phlegmasia cerulea dolens is a rare but serious complication of deep venous thrombosis, which can lead to arterial compromise, tissue ischemia, and gangrene. It typically presents in an elderly population often with coexistent malignancy. There have been no reported cases in the ambulatory pediatric population. The authors report a case of a 5-year-old girl who presented with acute, extensive left lower extremity deep venous thrombosis resulting in phlegmasia cerulea dolens. Pharmacologic and mechanical interv… Show more

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Cited by 5 publications
(2 citation statements)
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“…Occurrence of PCD in healthy pediatric patients is rare. 1 , 2 , 3 Potential protective mechanisms cited include a decreased capacity for thrombin generation, increased alpha-2 macroglobulin inhibition of thrombin, and the antithrombotic potential of the vessel wall. 2 Among adult and pediatric patients, malignancy, sepsis, surgery, hypercoagulable state, and vascular injury (indwelling central lines) predispose to PCD.…”
mentioning
confidence: 99%
“…Occurrence of PCD in healthy pediatric patients is rare. 1 , 2 , 3 Potential protective mechanisms cited include a decreased capacity for thrombin generation, increased alpha-2 macroglobulin inhibition of thrombin, and the antithrombotic potential of the vessel wall. 2 Among adult and pediatric patients, malignancy, sepsis, surgery, hypercoagulable state, and vascular injury (indwelling central lines) predispose to PCD.…”
mentioning
confidence: 99%
“…Phlegmasia alba/cerulea dolens: extensive venous thrombosis with total occlusion of venous flow, increased compartment pressures and compromise of arterial blood flow ( 37 ).…”
Section: Indications and Patient Selectionmentioning
confidence: 99%