A multimodal imaging study in U.S. veterans of Operations Iraqi and Enduring Freedom with and without major depression after blast-related concussion

Matthews, Scott C.; Strigo, Irina A.; Simmons, Alan N.; O’Connell, Ryan M.; Reinhardt, Lindsay E.; Moseley, Suzanne

doi:10.1016/j.neuroimage.2010.04.269

Cited by 137 publications

(88 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wu et al activation, and MR spectroscopy are linked in mTBI (151,179,180). Work by Kou et al examined serum in combination with imaging biomarkers and showed that glial biomarkers correlated with presence of intracranial hemorrhages detected with susceptibilityweighted imaging, while abnormal FA and WM volumes were correlated with impaired neurofunctional status (181).…”

Section: State Of the Art: Mr Imaging Applications In Mild Traumatic mentioning

confidence: 99%

MR Imaging Applications in Mild Traumatic Brain Injury: An Imaging Update

Wu¹,

Kirov²,

Gonen³

et al. 2016

Radiology

View full text Add to dashboard Cite

Mild traumatic brain injury (mTBI), also commonly referred to as concussion, affects millions of Americans annually. Although computed tomography is the first-line imaging technique for all traumatic brain injury, it is incapable of providing long-term prognostic information in mTBI. In the past decade, the amount of research related to magnetic resonance (MR) imaging of mTBI has grown exponentially, partly due to development of novel analytical methods, which are applied to a variety of MR techniques. Here, evidence of subtle brain changes in mTBI as revealed by these techniques, which are not demonstrable by conventional imaging, will be reviewed. These changes can be considered in three main categories of brain structure, function, and metabolism. Macrostructural and microstructural changes have been revealed with threedimensional MR imaging, susceptibility-weighted imaging, diffusion-weighted imaging, and higher order diffusion imaging. Functional abnormalities have been described with both task-mediated and resting-state blood oxygen leveldependent functional MR imaging. Metabolic changes suggesting neuronal injury have been demonstrated with MR spectroscopy. These findings improve understanding of the true impact of mTBI and its pathogenesis. Further investigation may eventually lead to improved diagnosis, prognosis, and management of this common and costly condition.q RSNA, 2016

show abstract

Section: State Of the Art: Mr Imaging Applications In Mild Traumatic mentioning

confidence: 99%

MR Imaging Applications in Mild Traumatic Brain Injury: An Imaging Update

Wu¹,

Kirov²,

Gonen³

et al. 2016

Radiology

View full text Add to dashboard Cite

show abstract

“…30,31 One study, however, reported that SLF changes may be associated with comorbid depression independent of mTBI in this patient population. 32 The main strength of this study is the enrollment of a unique patient population of service members exposed to concussive intensity blast in combat and a control population recruited in the same environment. Prior small-sample human blast-related mTBI studies used participants exposed to subconcussive intensity blasts as part of military training.…”

Section: Participants Screening Of 230 Us Active Duty Military Servimentioning

confidence: 99%

Clinical and imaging assessment of acute combat mild traumatic brain injury in Afghanistan

et al. 2015

View full text Add to dashboard Cite

Objective: To evaluate whether diffusion tensor imaging (DTI) will noninvasively reveal white matter changes not present on conventional MRI in acute blast-related mild traumatic brain injury (mTBI) and to determine correlations with clinical measures and recovery.Methods: Prospective observational study of 95 US military service members with mTBI enrolled within 7 days from injury in Afghanistan and 101 healthy controls. Assessments included Rivermead Post-Concussion Symptoms Questionnaire (RPCSQ), Post-Traumatic Stress Disorder Checklist Military (PCLM), Beck Depression Inventory (BDI), Balance Error Scoring System (BESS), Automated Neuropsychological Assessment Metrics (ANAM), conventional MRI, and DTI.Results: Significantly greater impairment was observed in participants with mTBI vs controls: RPCSQ (19.7 6 12.9 vs 3.6 6 7.1, p , 0.001), PCLM (32 6 13.2 vs 20.9 6 7.1, p , 0.001), BDI (7.4 6 6.8 vs 2.5 6 4.9, p , 0.001), and BESS ( Conclusions: Somatic, behavioral, and cognitive symptoms and performance deficits are substantially elevated in acute blast-related mTBI. Postconcussive symptoms and performance on measures of posttraumatic stress disorder, depression, and neurocognitive performance at initial presentation correlate with return-to-duty time. Although changes in fractional anisotropy are uncommon and subtle, DTI is more sensitive than conventional MRI in imaging white matter integrity in blast-related mTBI acutely. Blast-related mild traumatic brain injury (mTBI) has emerged as one of the most prevalent war injuries sustained by service members in the conflicts in Afghanistan and Iraq.

show abstract

“…46 A recent magnetic resonance imaging study involving combat veterans with a self-reported history of blast-related concussion showed that 11 veterans without depression had greater fractional anisotropy values in the SLF than 11 veterans who had depression, a finding 20 30 40 50 60 20 30 40 50 60 20 30 40 50 60 20 30 40 50 60 45 50 20 25 30 35 40 45 50 20 25 30 35 40 45 50 20 25 30 35 40 that might also support the idea that greater fractional anisotropy is associated with resilience against depression. 47 In experimental studies, resilience to stress has been associated with the capacity to constrain stress-induced increases in corticotrophin-releasing hormone and corticosterone through an elaborated negative feedback system 48,49 and via expression of brain-derived neurotrophic factor (BDNF). 50,51 In turn, BDNF function has been found to be associated with structural brain changes.…”

Section: J Psychiatry Neurosci 2012;37(1)mentioning

confidence: 99%