A multimeric MR-optical contrast agent for multimodal imaging

Harrison, Victoria S. R.; Carney, Christiane E.; MacRenaris, Keith W.; Meade, Thomas J.

doi:10.1039/c4cc05651e

Cited by 31 publications

(70 citation statements)

References 25 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both agents achieved outstanding tumor cell labeling capability and were detectable in vivo using both MR and optical imaging. 65 Accumulation of these agents in a nude mouse MCF7 tumor xenograft model was detected with fluorescence imaging, and renal clearance by MR imaging. 24 …”

Section: Tumor Xenograft Mouse Modelsmentioning

confidence: 99%

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

2016

View full text Add to dashboard Cite

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy," J. Biomed. Opt. 21(5), 050901 (2016), doi: 10.1117/1.JBO.21.5.050901. Abstract. A class of near-infrared fluorescence (NIRF) heptamethine cyanine dyes that are taken up and accumulated specifically in cancer cells without chemical conjugation have recently emerged as promising tools for tumor imaging and targeting. In addition to their fluorescence and nuclear imagingbased tumor-imaging properties, these dyes can be developed as drug carriers to safely deliver chemotherapy drugs to tumors. They can also be used as effective agents for photodynamic therapy with remarkable tumoricidal activity via photodependent cytotoxic activity. The preferential uptake of dyes into cancer but not normal cells is co-operatively mediated by the prevailing activation of a group of organic aniontransporting polypeptides on cancer cell membranes, as well as tumor hypoxia and increased mitochondrial membrane potential in cancer cells. Such mechanistic explorations have greatly advanced the current application and future development of NIRF dyes and their derivatives as anticancer theranostic agents. This review summarizes current knowledge and emerging advances in NIRF dyes, including molecular characterization, photophysical properties, multimodal development and uptake mechanisms, and their growing potential for preclinical and clinical use.

show abstract

Section: Tumor Xenograft Mouse Modelsmentioning

confidence: 99%

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

2016

View full text Add to dashboard Cite

show abstract

“…Synthesis of Gd(III)‐biotin employed the synthetic strategy described in to achieve 3‐‐Tris(1‐2(hydroxyl‐3‐(1H‐1,2,3‐triazol‐1‐yl(propyl)‐3,7,10‐tris(carboxymethyl)‐1,4,7,10‐tetraazacyclododecylgadolinium(III)phenoxy)‐propan‐1‐amine (C3‐amine). C3‐amine (1.6 mg, 0.0008 mmol) was suspended in 200 μL, pH 9.4 bicarbonate buffer under inert atmosphere.…”

Section: Methodsmentioning

confidence: 99%

Magnetic barcode imaging for contrast agents

Hung

Lilley

et al. 2016

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

Purpose To demonstrate a new MR imaging approach that unambiguously identifies and quantitates contrast agents based on intrinsic agent properties such as r1, r2, r2*, and magnetic susceptibility. The approach is referred to as Magnetic Barcode Imaging (MBI). Methods Targeted and bio-responsive contrast agents were imaged in agarose phantoms to generate T1, T2, T2*, and quantitative susceptibility maps. The parameter maps were processed by a machine learning algorithm trained to recognize the contrast agents based on these parameters. The output is a quantitative map of contrast agent concentration, identity, and functional state. Results MBI allowed the quantitative interpretation of intensities, removed confounding backgrounds, enabled contrast agent multiplexing, and unambiguously detected the activation and binding states of bio-responsive and targeted contrast agents. Conclusion MBI has the potential to overcome significant limitations in the interpretation, quantitation, and multiplexing of contrast enhancement by MR imaging probes.

show abstract

“…19). 201 Dendrimers have also been used to encapsulate other nanoparticles, such as Au-NPs 202 and IONPs, 203 to form dendrimer entrapped nanoparticles (DENPs). The dendrimer entrapment renders those nanoparticles with enhanced biocompatibilities and tunable surface functionalities.…”

Section: Dendrimer-based Nanoprobesmentioning

confidence: 99%

Nanoparticulate Contrast Agents for Multimodality Molecular Imaging

Xia¹,

Murukeshan²,

Su³

et al. 2016

j biomed nanotechnol

View full text Add to dashboard Cite

Molecular imaging is rapidly developing as a powerful tool in research and medical diagnostic. By integrating complementary signal reporters into a single nanoparticulate contrast agent, multimodal molecular imaging can be performed as scalable images with high sensitivity, resolution and specificity. In this review, multifunctional nanoparticles (MFNPs) are classified into four types: conjugation, encapsulation, core/shell, and co-doping. Further, new constructs of MFNPs were reported recently which have used nanoparticulate contrast agent such as quantum dots (QDs), iron oxide nanoparticles (IONPs), Upconversion nanoparticles (UCNPs), carbon based nanoparticles, gold nanoparticles (Au-NPs), Metal-Organic Frameworks (MOFs), dendrimers and porphyrins based nanoparticles. Different surface modification strategies were also developed as well as ligands are attached to those NPs to render the biocompatibility and enable specific targeting. These new development in MFNPs are expected to introduce a paradigm shift in multi-modal molecular imaging and thereby opening up an era of personalized medicine and new diagnostic medical imaging tools.

show abstract

A multimeric MR-optical contrast agent for multimodal imaging

Cited by 31 publications

References 25 publications

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

Magnetic barcode imaging for contrast agents

Nanoparticulate Contrast Agents for Multimodality Molecular Imaging

Contact Info

Product

Resources

About