Abstract. Neighborhood-based social interactions have gained attention as a research topic in recent decades in light of urban policies that aim to improve livability in urban areas. Social interactions are anticipated to play an important role in neighborhood livability; however, empirical studies investigating the extent to which neighborhood characteristics can improve social contacts among residents are scarce and inconclusive. Therefore, this paper studies the role of socio-demographics and neighborhood characteristics in the formation of social network ties and social interactions with neighbors. These relationships are analyzed using a multi-level path analysis approach based on data collected in 2011 from a survey of 751 respondents in 70 neighborhoods of Eindhoven, the Netherlands. The results indicate that neighborhood-based contacts are influenced by personal and household characteristics, such as education, income, work status, ethnicity, household composition, and years at the current address. The effect of neighborhood characteristics is limited, and only one significant relationship was found -between neighborhood income and the number of neighbors in the network. This finding is inconsistent with the assumption that an adjustment of neighborhood characteristics can lead to increasing social interaction among neighbors.