A multifunctional shape-adaptive and biodegradable hydrogel with hemorrhage control and broad-spectrum antimicrobial activity for wound healing

Gao, Lingling; Chen, Jingjie; Feng, Wei; Song, Qing; Huo, Jianhua; Yu, Luofeng; Liu, Nian; Wang, Tengjiao; Li, Peng; Huang, Wei

doi:10.1039/d0bm00800a

Cited by 77 publications

(62 citation statements)

References 59 publications

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“…Recently, some mussel‐inspired polymer hydrogels including polysaccharides, polypeptides, and PEG counterparts have been fabricated by covalent cross‐linking, supramolecular interactions, and/or both of those strategies. [ 33,35,39 ] Herein, we design a simple kind of glycopolypeptide (PGD) and fabricate two kinds of coordinated and covalent hydrogels. As illustrated in Figure 1A, both R‐Gels and V‐Gels were easily prepared in FeCl 3 and HRP/H 2 O 2 in PBS (10 m m , pH 7.4) at room temperature, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…These in vivo hemostasis results were better than those of some mussel‐inspired polysaccharides, polypeptides and PEG hydrogels reported in recent literatures (Figure S6A, Supporting Information). [ 30,32,33,39 ] The superior hemostasis might be attributed to the facts that 1) when the injectable glycopolypeptide hydrogels were applied to the bleeding wound sites, they would seal wound sites by wet adhesion and form physical barriers to prevent bleeding; [ 13,30,35 ] and 2) especially they have large microporous structures with multiple glucoses, positively charged amines, and catechols on the interfaces, which enable them adsorb RBCs and platelets and accelerate blood coagulation without blocking by various physical, electrostatic, and H‐bonding interactions. [ 30,46 ]…”

Section: Resultsmentioning

confidence: 99%

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Biomimetic Glycopolypeptide Hydrogels with Tunable Adhesion and Microporous Structure for Fast Hemostasis and Highly Efficient Wound Healing

Teng

Shao

Bai

et al. 2021

Adv Funct Materials

156

136

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Despite clinical applications of the first‐generation tissue adhesives and hemostats, the correlation among microstructure and hemostasis of hydrogels with wound healing is less understood and it is elusive to design high‐performance hydrogels to meet worldwide growing demands in wound closure, hemostasis, and healing. Inspired by the microstructure of extracellular matrix and mussel‐mimetic chemistry, two kinds of coordinated and covalent glycopolypeptide hydrogels are fabricated, which present tunable tissue adhesion strength (14.6–83.9 kPa) and microporous structure (8–18 µm), and lower hemolysis <1.5%. Remarkably, the microporous size mainly controls the hemostasis, and those hydrogels with larger pores of 16–18 µm achieve the fastest hemostasis of ≈14 s and the lowest blood loss of ≈6% than fibrin glue and others. Moreover, both biocompatibility and hemostasis affect wound healing performance, as assessed by hemolysis, cytotoxicity, subcutaneous implantation, and hemostasis and healing assays. Importantly, the glycopolypeptide hydrogel‐treated rat‐skin defect model achieves full wound closure and regenerates thick dermis and epidermis with some hair follicles on day 14. Consequently, this work not only establishes a versatile method for constructing glycopolypeptide hydrogels with tunable adhesion and microporous structure, fast hemostasis, and superior healing functions, but also discloses a useful rationale for designing high‐performance hemostatic and healing hydrogels.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Biomimetic Glycopolypeptide Hydrogels with Tunable Adhesion and Microporous Structure for Fast Hemostasis and Highly Efficient Wound Healing

Teng

Shao

Bai

et al. 2021

Adv Funct Materials

156

136

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“…Porosity is a property of hydrogels that is important for tissue regeneration [22,23]. Porous hydrogels provide the necessary space for cell growth and vascularization [24][25][26]. It is well-known that such a three-dimensional (3D) structure of hydrogels is necessary to achieve successful oral tissue regeneration because it can be used as a delivery vehicle for bioactive substances in cells [22].…”

Section: Hgf Viability In Krt-based Fibrin Hydrogels: Cytotoxicity St...mentioning

confidence: 99%

Injectable Human Hair Keratin–Fibrinogen Hydrogels for Engineering 3D Microenvironments to Accelerate Oral Tissue Regeneration

Kang

et al. 2021

IJMS

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Traumatic injury of the oral cavity is atypical and often accompanied by uncontrolled bleeding and inflammation. Injectable hydrogels have been considered to be promising candidates for the treatment of oral injuries because of their simple formulation, minimally invasive application technique, and site-specific delivery. Fibrinogen-based hydrogels have been widely explored as effective materials for wound healing in tissue engineering due to their uniqueness. Recently, an injectable foam has taken the spotlight. However, the fibrin component of this biomaterial is relatively stiff. To address these challenges, we created keratin-conjugated fibrinogen (KRT-FIB). This study aimed to develop a novel keratin biomaterial and assess cell–biomaterial interactions. Consequently, a novel injectable KRT-FIB hydrogel was optimized through rheological measurements, and its injection performance, swelling behavior, and surface morphology were investigated. We observed an excellent cell viability, proliferation, and migration/cell–cell interaction, indicating that the novel KRT-FIB-injectable hydrogel is a promising platform for oral tissue regeneration with a high clinical applicability.

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“…The possibility of modulation the degradation rate of hydrogels has been also considered in the treatment of wounds with a poor tendency to healing [33]: no removal costs are required, with risk of suffering and, in the case of injuries, bleeding [34,35]. A hydrogel that degrades in coincidence with the wound repair process is able to significantly reduce the discomfort to the patient [31].…”

Section: Hydrogel Degradationmentioning

confidence: 99%

Hydrogel-Based Delivery for Antineoplastic Drugs and Vascular Scaffolding

Iervolino¹,

Chello²,

Chello³

et al. 2021

Preprint

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Hydrogels, hydrophilic polymeric compounds, have been recently put under investigation as regenerative medicine applications and delivery systems for antineoplastic drugs, particularly chemotherapeutics (anthracyclines, alkylating agents), target drugs (trastuzumab) and immunotherapies. Porosity, conductivity, biodegradability and physical states are some of the peculiarities that render hydrogels suitable for therapies implementation. Chemically-modifying agents and enzymes can be also coupled to hydrogels for pharmacokinetical parameters improvement and side effects avoidance. Cardiotoxicity is in fact one of the major issues for oncological patients after treatment efficacy. Heart failure, myocarditis and hypertension are causes of morbidity and mortality that can possibly be avoided. Specific reaching of the target tumor site has been achieved by several authors in preclinical in vivo studies but clinical studies are currently under design processes. Polydioxanone, a hydrogel-mimicking agent, is capable to interact with the elastic properties of pulmonary artery. An advantageous characteristic is that can be also reabsorbed within biological systems and can cause a remodeling process of the vessel wall. Hydrogels currently represent a strong topic of interest for researchers and probably will guide future clinical investigations and practice.

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A multifunctional shape-adaptive and biodegradable hydrogel with hemorrhage control and broad-spectrum antimicrobial activity for wound healing

Abstract: An injectable hydrogel wound dressing based on an oxidized dextran and ε-poly-l-lysine network has multiple biological activities.

Cited by 77 publications

References 59 publications

Biomimetic Glycopolypeptide Hydrogels with Tunable Adhesion and Microporous Structure for Fast Hemostasis and Highly Efficient Wound Healing

Biomimetic Glycopolypeptide Hydrogels with Tunable Adhesion and Microporous Structure for Fast Hemostasis and Highly Efficient Wound Healing

Injectable Human Hair Keratin–Fibrinogen Hydrogels for Engineering 3D Microenvironments to Accelerate Oral Tissue Regeneration

Hydrogel-Based Delivery for Antineoplastic Drugs and Vascular Scaffolding

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