A multifunctional polymeric coating with self-adsorbed, antifouling and <i>in situ</i> remineralization properties for caries management

Chu, Wenlin; Tang, Haiqin; Dong, Zhiyun; Hou, Ailin; Qiu, Rongmin; Xu, Xinyuan; Yang, Jiaojiao; He, Libang; Luo, Jun; Li, Jianshu

doi:10.1039/d3tb00377a

Cited by 4 publications

(3 citation statements)

References 59 publications

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“…In recent years, it has been a preferred strategy for the assembly of mineral nanostructures on membranes by spontaneous mineralization that achieved through modifying the polymer membranes and then adding mineralized raw materials. [68][69][70] This type of study focuses on constructing groups with strong electrical, polar, physical, and chemical interactions with mineral ions on the membrane surface. By doing so, it creates crystal growth sites on the membrane surface, leading to thermodynamically spontaneous and orderly nucleation and crystal growth in the pre-mineralized body fluids.…”

Section: Interfacial Compatilization Inducing Mineralizationmentioning

confidence: 99%

Construction of Mineralization Nanostructures in Polymers for Mechanical Enhancement and Functionalization

Lv,

Wang,

Zhang

2024

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Mineralization capable of growing inorganic nanostructures efficiently, orderly, and spontaneously shows great potential for application in the construction of high‐performance organic–inorganic composites. As a thermodynamically spontaneous solid‐phase crystallization reaction involving dual organic and inorganic components, mineralization allows for the self‐assembly of sophisticated and exclusive nanostructures within a polymer matrix. It results in a diversity of functions such as enhanced strength, toughness, electrical conductivity, selective permeability, and biocompatibility. While there are previous reviews discussing the progress of mineralization reactions, many of them overlook the significant benefits of interfacial regulation and functionalization that come from the incorporation of mineralized structures into polymers. Focusing on different means of assembly of mineralized nanostructures in polymer, the work analyzes their design principles and implementation strategies. Then, their different advantages and disadvantages are analyzed by combining nanostructures with organic substrates as well as involving the basis of different functionalizations. It is anticipated to provide insights and guidance for the future development of mineralized polymer composites and their application designs.

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Section: Interfacial Compatilization Inducing Mineralizationmentioning

confidence: 99%

Construction of Mineralization Nanostructures in Polymers for Mechanical Enhancement and Functionalization

Lv,

Wang,

Zhang

2024

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“…The use of a PEG has significant applications in drug delivery systems and bioassays. In bioassays, the PEG can minimize background noise by reducing nonspecific adsorption of biomolecules, resulting in improved accuracy and sensitivity. ,, …”

Section: Introductionmentioning

confidence: 99%

“…In reducing nonspecific adsorption of biomolecules, resulting in improved accuracy and sensitivity. 9,18,19 There are two typical strategies for introducing antifouling moieties onto PEDOT. (1) 3,4-ethylenedioxythiophene (EDOT) monomer directly bonded with antifouling moieties, such as EDOT-PC, 20 EDOT-SB, 21 and EDOT-CB.…”

Section: ■ Introductionmentioning

confidence: 99%

In Situ Growth of Columnar PEG on PEDOT and Its Antifouling Properties

Hai,

Liu,

Tian

et al. 2024

Langmuir

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The antifouling properties of conductive polymers have received extensive attention for biosensor and bioelectronic applications. Polyethylene glycol (PEG) is a wellknown antifouling material, but the controlled regulation of the surface topography of PEG without a template remains a challenge. Here, we show a columnar structure antifouling conductive polymer brush with enhanced antifouling properties and considerable conductivity. The method involves synthesizing the 3,4-ethylenedioxythiophene monomer modified with azide (EDOT-N 3 ), the electropolymerization of PEDOT-N 3 , and the in situ growth of PEG polymer brushes on PEDOT through double-click reactions. The resultant columnar structure polymer brush exhibits high electrical conductivity (3.5 Ω•cm 2 ), ultrahigh antifouling property, electrochemical stability (capacitance retention was 93.8% after 2000 cycles of CV scans in serum), and biocompatibility.

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A Bioartificial Pancreas with “Immune Stealth” and Continuous Oxygen Supply for Islet Transplantation

Zheng,

Yang,

Gao

et al. 2023

Macromol. Rapid Commun.

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Transplantation of microencapsulated islet cells remains a promising strategy for the normalization of glucose metabolism control in type 1 diabetes mellitus. However, vigorous host immunologic rejection, fibrotic overgrowth around the microcapsules and poor oxygen supply often lead to graft failure. Herein, a bioartificial pancreas is constructed that incorporates the “stealth effect” based on polyethylene glycol copolymers and the high oxygen‐carrying performance of fluorinated nanoparticles. Polycationic poly(L‐lysine)‐grafted‐poly(ethylene glycol) is successfully coated on the surface of alginate microcapsules through electrostatic interaction, which can not only resist fibrinogen adhesion and avoid excessive fibrosis around the microcapsules, but also isolate the host immune system from attacking, achieving a “stealth effect” of microencapsulated islet cells. Furthermore, the co‐loading of fluoride‐based O2 nanocarriers gives them enhanced oxygen‐carrying and continuous oxygen supply capabilities, thereby effectively prolonging the survival of islet cells. The intracapsular islet cells still display similar cell viability and almost normal insulin secretion function even in long‐term culture under hypoxic conditions. Collectively, this work opens up a new approach for microencapsulated islets to efficiently evade host immune attack and improve oxygen supply, and provides a promising strategy for islet transplantation in type 1 diabetes mellitus.This article is protected by copyright. All rights reserved

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A multifunctional polymeric coating with self-adsorbed, antifouling and in situ remineralization properties for caries management

Abstract: Dental caries is a biofilm-induced bacterial infectious oral disease , where the early attachment of proteins and pathogenic bacteria to tooth surfaces has been known as the main cause of...

Cited by 4 publications

References 59 publications

Construction of Mineralization Nanostructures in Polymers for Mechanical Enhancement and Functionalization

Construction of Mineralization Nanostructures in Polymers for Mechanical Enhancement and Functionalization

In Situ Growth of Columnar PEG on PEDOT and Its Antifouling Properties

A Bioartificial Pancreas with “Immune Stealth” and Continuous Oxygen Supply for Islet Transplantation

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