A Multifunctional Platform for Tumor Angiogenesis-Targeted Chemo-Thermal Therapy Using Polydopamine-Coated Gold Nanorods

Abstract

Image-guided combined chemo-thermal therapy assists in optimizing treatment time, enhancing therapeutic efficiency, and circumventing side effects. In the present study, we developed a chemo-photothermal theranostic platform based on polydopamine (PDA)-coated gold nanorods (GNRs). The PDA coating was thin; however, it significantly suppressed the cytotoxicity of the cetyltrimethylammonium bromide template and allowed high cisplatin loading efficiency, arginine-glycine-aspartic acid (RGD) peptide (c(RGDyC)) conjugation, and chelator-free iodine-125 labeling (RGD-IPt-PDA@GNRs). While loaded cisplatin was released in a pH-sensitive manner, labeled I was outstandingly stable under biological conditions. RGD-IPt-PDA@GNRs had a high specificity for αvβ integrin, and consequently, they could selectively accumulate in tumors, as revealed by single photon emission computed tomography/CT imaging, and in target tumor angiogenic vessels, as shown by high-resolution photoacoustic imaging. As RGD-IPt-PDA@GNRs targets tumor angiogenesis, it is a highly potent tumor therapy. Combined chemo-photothermal therapy with probes could thoroughly ablate tumors and inhibit tumor relapse via a synergistic antitumor effect. Our studies demonstrated that RGD-IPt-PDA@GNRs is a robust platform for image-guided, chemo-thermal tumor therapy with outstanding synergistic tumor killing and relapse inhibition effects.

Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles

“…First, the Bi 2 S 3 @mPS NPs reacted with (3-aminopropyl) triethoxysilane (APTES) for 48 h in ethanol to form NPs terminated with an amino group. Then the resultant Bi 2 S 3 @mPS-NH 2 reacted with NHS-PEG-Mal via Michael addition reaction [25] to form Bi 2 S 3 @mPS-PEG-Mal NPs. The activated Bi 2 S 3 @mPS-PEG-Mal NPs were then covalently coupled to thiolated Tam (SH-Tam) through thiol-maleimide linkages.…”

Plasmonic Photothermal Nanoparticles for Biomedical Applications

“…Obviously, particle size and shape effect along with particle surface charge/modification effect should be also considered together, and all these affect biodistribution, targeting efficiency, circulation time, and excretion in a collective manner. [120] Furthermore, PTI can be combined with photothermal therapy (PTT) under the same light radiation; thus, it can offer not only easy accessibility for multimodal molecular imaging but also an efficient tool for real-time imaging-guided therapy. [69] Up to now, various types of plasmonic nanoparticles have been applied to PTI, and PTI has garnered much attention in biomolecular imaging due to its potential in sensitivity, realtime monitoring, rapid recording with simple instruments and convenient use.…”

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal‐Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging

“…Moreover, it is not affected by photobleaching. All these features make lifetime‐resolved imaging an accurate and reliable method to measure the microenvironmental changes of a fluorophore 9. Owing to their high spin–orbit coupling associated with the heavy metal ion, metal complexes are ideal candidates for phosphorescence lifetime imaging microscopy (PLIM) with emission lifetimes up to microsecond that can totally deplete the background emission (usually below 10 ns).…”