A multifunctional nanoplatform based on graphitic carbon nitride quantum dots for imaging-guided and tumor-targeted chemo-photodynamic combination therapy

Zhang, Wenxian; Dang, Guangyao; Dong, Jian; Li, Yanyan; Jiao, Peng; Yang, Mo; Zou, Xianwen; Cao, Yutao; Ji, Haiwei; Dong, Lifeng

doi:10.1016/j.colsurfb.2020.111549

Cited by 27 publications

(14 citation statements)

References 40 publications

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“…The fluorescence image of the PHI microswimmers shows that the microswimmers stayed in the vicinity of the cancer cells (Fig. 4H) ( 66 ). This demonstrates that PHI microswimmers serve as smart light-driven cargo delivering agents under biological conditions.…”

Section: Resultsmentioning

confidence: 99%

“…The fluorescent image of the PHI microswimmers shows that the microswimmers stayed in the vicinity of the cancer cells (Figure 4h). 69 This demonstrates that PHI microswimmers serve as smart light-driven cargo delivering agents in biological conditions. In fact, their stimuli-responsive behavior triggers a theranostic function, making use of an intrinsic sensing property (i.e., charge accumulation enabled in oxygen-poor environments) that triggers an enhanced release of the therapeutic agents.…”

Section: Drug Loading and Hypoxically Ph-and Light-triggered Drug Rel...mentioning

confidence: 92%

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Light-driven carbon nitride microswimmers with propulsion in biological and ionic media and responsive on-demand drug delivery

et al. 2022

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We propose two-dimensional poly(heptazine imide) (PHI) carbon nitride microparticles as light-driven microswimmers in various ionic and biological media. Their high-speed (15 to 23 micrometer per second; 9.5 ± 5.4 body lengths per second) swimming in multicomponent ionic solutions with concentrations up to 5 M and without dedicated fuels is demonstrated, overcoming one of the bottlenecks of previous light-driven microswimmers. Such high ion tolerance is attributed to a favorable interplay between the particle’s textural and structural nanoporosity and optoionic properties, facilitating ionic interactions in solutions with high salinity. Biocompatibility of these microswimmers is validated by cell viability tests with three different cell lines and primary cells. The nanopores of the swimmers are loaded with a model cancer drug, doxorubicin (DOX), resulting in a high (185%) loading efficiency without passive release. Controlled drug release is reported under different pH conditions and can be triggered on-demand by illumination. Light-triggered, boosted release of DOX and its active degradation products are demonstrated under oxygen-poor conditions using the intrinsic, environmentally sensitive and light-induced charge storage properties of PHI, which could enable future theranostic applications in oxygen-deprived tumor regions. These organic PHI microswimmers simultaneously address the current light-driven microswimmer challenges of high ion tolerance, fuel-free high-speed propulsion in biological media, biocompatibility, and controlled on-demand cargo release toward their biomedical, environmental, and other potential applications.

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Section: Resultsmentioning

confidence: 99%

Section: Drug Loading and Hypoxically Ph-and Light-triggered Drug Rel...mentioning

confidence: 92%

Light-driven carbon nitride microswimmers with propulsion in biological and ionic media and responsive on-demand drug delivery

et al. 2022

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“…For instance, if the electrochemical potential is set below the diazonium salt reduction potential (−515 mV) but above or below the reduction potential of GO x (−950 mV), the interface can be switched between Si–GO x –diazonium and Si–rGO x –diazonium interfaces. This offers a new platform for molecular electronics where electrochemical gating can be used to switch not the molecules themselves but rather the electrode materials to which the molecules connect to. − …”

Section: Resultsmentioning

confidence: 99%

Impermeable Graphene Oxide Protects Silicon from Oxidation

Rahpeima

Dief

Ciampi

et al. 2021

ACS Appl. Mater. Interfaces

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The presence of a natural silicon oxide (SiO x ) layer over the surface of silicon (Si) has been a roadblock for hybrid semiconductor and organic electronics technology. The presence of an insulating oxide layer is a limiting operational factor, which blocks charge transfer and therefore electrical signals for a range of applications. Etching the SiO x layer by fluoride solutions leaves a reactive Si–H surface that is only stable for few hours before it starts reoxidizing under ambient conditions. Controlled passivation of silicon is also of key importance for improving Si photovoltaic efficiency. Here, we show that a thin layer of graphene oxide (GO x ) prevents Si surfaces from oxidation under ambient conditions for more than 30 days. In addition, we show that the protective GO x layer can be modified with molecules enabling a functional surface that allows for further chemical conjugation or connections with upper electrodes, while preserving the underneath Si in a nonoxidized form. The GO x layer can be switched electrochemically to reduced graphene oxide, allowing the development of a dynamic material for molecular electronics technologies. These findings demonstrate that 2D materials are alternatives to organic self-assembled monolayers that are typically used to protect and tune the properties of Si and open a realm of possibilities that combine Si and 2D materials technologies.

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“…First, tumor cells targeting ligands mainly include antibodies or peptides, 14,175 hyaluronic acid (HA), 158,176 and folic acid (FA). 25,[177][178][179] Ding et al 14 produced a compound of photosensitizer P50 modified with HER2 antibody, demonstrating the potential of HER2-SCPNs to target SKBR-3 tumors. Feng et al 175 covalently coupled surface carboxyl-modified P51 with antibody (anti-EpCAM), which can detect MCF-7 tumor cells and localize them on the cell membrane, to accomplish targeted imaging of distinct regions of tumor cells.…”

Section: Targetingmentioning

confidence: 99%

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Sun¹,

Xue²,

Zhang³

2022

IJN

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Photodynamic therapy (PDT) is a noninvasive therapy for cancer and bacterial infection. Metal-free semiconducting conjugated polymers (SCP S ) with good stability and optical and electrical properties are promising photosensitizers (PSs) for PDT compared with traditional small-molecule PSs. This review analyzes the latest progress of strategies to improve PDT effect of linear, planar, and three-dimensional SCP S , including improving solubility, adjusting conjugated structure, enhancing PS-doped SCPs, and combining therapies. Moreover, the current issues, such as hypoxia, low penetration, targeting and biosafety of SCP S, and corresponding strategies, are discussed. Furthermore, the challenges and potential opportunities on further improvement of PDT for SCPs are presented.

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A multifunctional nanoplatform based on graphitic carbon nitride quantum dots for imaging-guided and tumor-targeted chemo-photodynamic combination therapy

Cited by 27 publications

References 40 publications

Light-driven carbon nitride microswimmers with propulsion in biological and ionic media and responsive on-demand drug delivery

Light-driven carbon nitride microswimmers with propulsion in biological and ionic media and responsive on-demand drug delivery

Impermeable Graphene Oxide Protects Silicon from Oxidation

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

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