A Multifunctional Nanoplatform against Multidrug Resistant Cancer: Merging the Best of Targeted Chemo/Gene/Photothermal Therapy

Abstract

Synergistic therapy that combines chemo-, gene-, or photothermal means shows great potential for enhancing the therapeutic effects on cancers. Tumor-targeted nanoparticles based on a doxorubicin (DOX)-gated mesoporous silica nanocore (MSN) encapsulated with permeability glycoprotein (P-gp) small interfering RNA (siRNA) and a polydopamine (PDA) outer layer for DOX loading and folic acid decoration are designed. The multifunctional nanoplatform tactfully integrates chemo-(DOX), gene-(P-gp siRNA), and photothermal (PDA layer) substances in one system. In vitro results reveal that DOX release behaviors are both pH-and thermal-responsive and the release of co-delivered P-gp siRNA is also pH-dependent due to the pH-cleavable DOX gatekeeper on MSN. In addition, due to the near-infrared light-responsive PDA outer layer and folic acid conjugation, the nanoparticles exhibit outstanding photothermal activity and selective cell targeting ability. Subsequently, in vitro and in vivo antitumor experiments both demonstrate the enhanced antitumor efficacy of the multifunctional nanoparticles, indicating the significance of synergistic therapy combining chemo-, gene-, and photothermal treatments in one system. Cancer Therapy

Co-delivery of dihydroartemisinin and docetaxel in pH-sensitive nanoparticles for treating metastatic breast cancerviathe NF-κB/MMP-2 signal pathway

“…36,37 For instance, doxorubicin has been designed to form stimuli-responsive nanoplatform using mesoporous silica nanomaterial with benzoic-imine bond, which upon cleavage in the acidic tumor environment, release DOX and other drug, which express better antitumor therapeutic efficiency in vitro and in vivo. 38,39 Here, we successfully synthesized pH-responsive materials 4-arm-PEG-DTX with hydrazone bonds (Fig. 1) and used it to encapsulate DHA to prepare pHsensitive D/D NPs (Fig.…”

Dynamically PEGylated and Borate‐Coordination‐Polymer‐Coated Polydopamine Nanoparticles for Synergetic Tumor‐Targeted, Chemo‐Photothermal Combination Therapy

“…Xenograft Tumor Model : The MCF‐7 cell xenograft tumor model was performed according to a previous method . All the protocols for the proposed in vivo experiments were approved by the Administrative Committee on Animal Research in the Tsinghua University.…”

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

“…Metal-organic framework (MOF), as a new class of hybrid materials, consists of inorganic building units covalently connected by organic building units. [43] Porphyrin-based MOF that have been developed so far for potential PDT outcome, however, almost all of them are compounded with other nanoparticles to form new compounds for synergistic treatment (such as PDT-PTT, PDT-Radiation therapy), [44] the complex structures would reduce the clinical medical value. [41,42] Porphyrins and porphyrin derivatives as photosensitizers are hydrophobic in nature, which not only cause insufficient selectivity to the site of tumor, but also leads to PS polymerization, reducing the efficacy of PDT and making it very attractive for the assembly structure of organic building units of MOF.…”