A multifunctional nanoparticle system combines sonodynamic therapy and chemotherapy to treat hepatocellular carcinoma

Liu, Yang; Wan, Guoyun; Guo, Hua; Liu, Yuanyuan; Zhou, Ping; Wang, Hemei; Wang, Dan; Zhang, Sipei; Wang, Yinsong; Zhang, Ning

doi:10.1007/s12274-016-1339-8

Cited by 59 publications

(47 citation statements)

References 41 publications

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“…Liu et al. constructed a core–shell nanostructure consisting of HP, doxorubicin (DOX), and Pluronic F68 (HPDF; Figure A) . The DOX and HP molecules self‐assembled into highly stable DOX/HP nanocomplexes through π‐π stacking, thereby enhancing the therapeutic capacity of SDT and overcoming the drug resistance.…”

Section: Organic Sonosensitizersmentioning

confidence: 99%

Section: Organic Sonosensitizersmentioning

confidence: 99%

“…The synergistic effect of chemotherapy and SDT was further demonstrated by the lowest viability of SMMC‐7721 cells with the combination treatment (Figure C), as well as the decrease in the subcutaneous tumor volume in nude mice and a significant increase in their survival rates (Figure S6). Similarly, the core–shell HPDF NPs consisting of HP and DOX also inhibited HCC cells by sono‐chemotherapy …”

Section: Biomedical Applications Of Sonosensitizersmentioning

confidence: 99%

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Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.

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Section: Organic Sonosensitizersmentioning

confidence: 99%

Section: Organic Sonosensitizersmentioning

confidence: 99%

Section: Biomedical Applications Of Sonosensitizersmentioning

confidence: 99%

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Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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“…During treatment period, the tumor sizes were monitored and the tumor volumes were calculated according to the ellipsoidal formula. 23 Meanwhile, the body weights of mice were also detected. When the treatments were completed, all mice were sacrificed, and the main organs and tumors were harvested for further histological analysis.…”

mentioning

confidence: 99%

Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Wang

Zhang

et al. 2017

IJN

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IR780, a near-infrared dye, can also be used as a photosensitizer both for photothermal therapy (PTT) and photodynamic therapy (PDT). In this study, we designed a simple but effective nanoparticle system for carrying IR780 and paclitaxel, thus hoping to combine PTT/PDT and chemotherapy to treat hepatocellular carcinoma (HCC). This nanosystem, named PDF nanoparticles, consisted of phospholipid/Pluronic F68 complex nanocores and pullulan shells. IR780 and paclitaxel were loaded separately into PDF nanoparticles to form PDFI and PDFP nanoparticles, which had regular sphere shapes and relatively small sizes. Upon near-infrared laser irradiation at 808 nm, PDFI nanoparticles showed strong PTT/PDT efficacy both in vitro and in vivo. In MHCC-97H cells, the combined treatment of PDFI nanoparticles/laser irradiation and PDFP nanoparticles exhibited significant synergistic effects on inhibiting cell proliferation and inducing cell apoptosis and cell cycle arrest at G2/M phase. In MHCC-97H tumor-bearing mice, PDFI nanoparticles exhibited excellent HCC-targeting and accumulating capability after intravenous injection. Furthermore, the combined treatment of PDFI nanoparticles/laser irradiation and PDFP nanoparticles also effectively inhibited the tumor growth and the tumor angiogenesis in MHCC-97H tumor-bearing mice. In summary, we put forward a therapeutic strategy for HCC treatment by combining PTT/PDT and chemotherapy.

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“…Current treatment regimens often are not effective because of the late stage of diagnosis and the inability to deliver the correct therapeutic dose to the liver [2]. Over the past few years, more effort has been concentrated in the development of multifunctional [3,4,5] or combination therapy [6,7,8] in order to improve existing anticancer treatments. This strategy has previously identified that combination therapy can result in synergy and overall can improve efficacy of therapies, as well as reduced drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy

et al. 2018

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Liver cancer treatments are often hindered by poor drug physicochemical properties, hence there is a need for improvement in order to increase patient survival and outlook. Combination therapies have been studied in order to evaluate whether increased overall efficacy can be achieved. This study reports the combined treatment of liver cancer cells with a combination treatment of chemotherapeutic agent paclitaxel and pro-apoptotic protein cytochrome C. In order to administer both agents in a single formulation, a poly(allylamine)-based amphiphile has been fabricated with the incorporation of a hybrid iron oxide-gold nanoparticle into its structure. Here, the insoluble paclitaxel becomes incorporated into the hydrophobic core of the self-assemblies formed in an aqueous environment (256 nm), while the cytochrome C attaches irreversibly onto the hybrid nanoparticle surface via gold-thiol dative covalent binding. The self-assemblies were capable of solubilising up to 0.698 mg/mL of paclitaxel (700-fold improvement) with 0.012 mg/mL of cytochrome C also attached onto the hybrid iron oxide-gold nanoparticles (HNPs) within the hydrophobic core. The formulation was tested on a panel of liver cancer cells and cytotoxicity was measured. The findings suggested that indeed a significant improvement in combined therapy (33-fold) was observed when compared with free drug, which was double the enhancement observed after polymer encapsulation without the cytochrome C in hepatocellular carcinoma (Huh-7D12) cells. Most excitingly, the polymeric nanoparticles did result in improved cellular toxicity in human endothelian liver cancer (SK-hep1) cells, which proved completely resistant to the free drug.

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A multifunctional nanoparticle system combines sonodynamic therapy and chemotherapy to treat hepatocellular carcinoma

Cited by 59 publications

References 41 publications

Ultrasound‐Activated Sensitizers and Applications

Ultrasound‐Activated Sensitizers and Applications

Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy

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