A Multifunctional Nanocomposite Hydrogel for Endoscopic Tracking and Manipulation

Augurio, Adriana; Cortelletti, Paolo; Tognato, R.; Rios, Anne C.; Levato, Riccardo; Malda, Jos; Alini, Mauro; Eglin, David; Giancane, Gabriele; Speghini, Adolfo; Serra, Tiziano

doi:10.1002/aisy.202070031

Cited by 9 publications

(9 citation statements)

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“…Other than magnetically‐actuated drug delivery, magnetic guidance is also attractive for enabling real‐time remote manipulation of constructs following implantation, as recently showed by incorporating SPIONs organized in filaments within methacrylated gelatin‐based hydrogels, thus allowing to set the preferential axis of magnetization of the entire nanocomposite platform. [ 161 ] Besides dictating the position of macroscale constructs, nanoparticle directional movement can pull and orient hydrogel matrices to achieve cell anisotropic alignment as observed in many biological tissues. [ 162,163 ] In particular, such type of nanocomposite hydrogels have showcased on‐demand cell alignment for directing nerve growth following injection, [ 164 ] as well as manufacturing soft robots with anisotropic matrices.…”

Section: Stimuli‐responsive Nanocomposite Hydrogels and Biomedical Apmentioning

confidence: 99%

Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Lavrador

Esteves

Gaspar

et al. 2020

Adv Funct Materials

308

201

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The complex tissue‐specific physiology that is orchestrated from the nano‐ to the macroscale, in conjugation with the dynamic biophysical/biochemical stimuli underlying biological processes, has inspired the design of sophisticated hydrogels and nanoparticle systems exhibiting stimuli‐responsive features. Recently, hydrogels and nanoparticles have been combined in advanced nanocomposite hybrid platforms expanding their range of biomedical applications. The ease and flexibility of attaining modular nanocomposite hydrogel constructs by selecting different classes of nanomaterials/hydrogels, or tuning nanoparticle‐hydrogel physicochemical interactions widely expands the range of attainable properties to levels beyond those of traditional platforms. This review showcases the intrinsic ability of hybrid constructs to react to external or internal/physiological stimuli in the scope of developing sophisticated and intelligent systems with application‐oriented features. Moreover, nanoparticle‐hydrogel platforms are overviewed in the context of encoding stimuli‐responsive cascades that recapitulate signaling interplays present in native biosystems. Collectively, recent breakthroughs in the design of stimuli‐responsive nanocomposite hydrogels improve their potential for operating as advanced systems in different biomedical applications that benefit from tailored single or multi‐responsiveness.

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Section: Stimuli‐responsive Nanocomposite Hydrogels and Biomedical Apmentioning

confidence: 99%

Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Lavrador

Esteves

Gaspar

et al. 2020

Adv Funct Materials

308

201

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“…[ 24 ] 3D printing technologies have already contributed to the fabrication of multi‐responsive and hierarchically organized soft nanocomposite hydrogels providing well‐defined environments for cell manipulation. [ 25,26 ]…”

Section: Introductionmentioning

confidence: 99%

“…The approach we describe could be applied using other platforms for the formation of spatially‐patterned magnetic hydrogels for many applications. [ 25,26 ] These capabilities facilitate control over stimulus‐response over length scales relevant to tissue engineering and provide the potential for high through‐put printed gel bed arrays for screening. [ 37 ] These applications and the technical development of the responsive gels, the 3D printing procedure, and the thermography are described in this article.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels

Monks

Wychowaniec

McKiernan

et al. 2020

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Multifunctional nanocomposites that exhibit well‐defined physical properties and encode spatiotemporally controlled responses are emerging as components for advanced responsive systems, for example, in soft robotics or drug delivery. Here an example of such a system, based on simple magnetic hydrogels composed of iron oxide magnetic nanoflowers and Pluronic F127 that generates heat upon alternating magnetic field irradiation is described. Rules for heat‐induction in bulk hydrogels and the heat‐dependence on particle concentration, gel volume, and gel exposed surface area are established, and the dependence on external environmental conditions in “closed” as compared to “open” (cell culture) system, with controllable heat jumps, of ∆T 0–12°C, achieved within ≤10 min and maintained described. Furthermore the use of extrusion‐based 3D printing for manipulating the spatial distribution of heat in well‐defined printed features with spatial resolution <150 µm, sufficiently fine to be of relevance to tissue engineering, is presented. Finally, localized heat induction in printed magnetic hydrogels is demonstrated through spatiotemporally‐controlled release of molecules (in this case the dye methylene blue). The study establishes hitherto unobserved control over combined spatial and temporal induction of heat, the applications of which in developing responsive scaffold remodeling and cargo release for applications in regenerative medicine are discussed.

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“…ZnO/γ-Fe 2 O 3 nanostructures were characterized by means of XRD in order to identify the crystalline phase of the two components. As reported in Figure 1 , ZnO shows the typical diffraction pattern of the zinc oxide in the wurtzite form (JPCS card 036-1451) and the iron oxide seems to maintain the original maghemite phase [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Photocatalytic Degradation of Tetracycline by ZnO/γ-Fe2O3 Paramagnetic Nanocomposite Material

et al. 2020

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In recent years, the presence of numerous xenobiotic substances, such as antibiotics, has been detected in water environments. They can be considered as environmental contaminants, even if their effect on human health has yet to be totally understood. Several approaches have been studied for the removal of these kinds of pollutants. Among these compounds, tetracycline (TC), a broad-spectrum antibiotic, is one of the most commonly found in water due to its widespread use. In the context of reducing the presence of TC in aqueous solution, in this contribution, a composite catalyst based on zinc oxide (ZnO) and iron oxide (γ-Fe2O3) was developed and its photocatalytic properties were investigated. The catalytic materials were synthesized by a microwave-assisted aqueous solution method and characterized by Field Emission Scanning Electron Microscope (FESEM), X-Ray Fluorescence (XRF) and Brunauer−Emmett−Teller (BET) analysis. The TC concentration was evaluated by spectrophotometer measurements at specific time intervals. The performed photocatalytic experiments clearly demonstrated that the ZnO/γ-Fe2O3 composite catalyst presents significant photocatalytic activity, indeed a TC degradation efficiency of 88.52% was registered after 150 min. The presence of iron oxide in the structure of the catalyst enhances both the surface area and the pore volume, facilitating the adsorption of the analyte on the surface of nanostructures, a fundamental phase to optimize a photodegradation process. Moreover, ZnO was found to play the key role in the photocatalytic process assisted by γ-Fe2O3 which enhanced the TC degradation efficiency by 20%.

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A Multifunctional Nanocomposite Hydrogel for Endoscopic Tracking and Manipulation

Cited by 9 publications

References 0 publications

Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels

Photocatalytic Degradation of Tetracycline by ZnO/γ-Fe2O3 Paramagnetic Nanocomposite Material

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