A multifunctional nano-therapeutic platform based on octahedral yolk-shell Au NR@CuS: Photothermal/photodynamic and targeted drug delivery tri-combined therapy for rheumatoid arthritis

Huang, Ru‐Qi; Zhang, Caiyi; Bu, Yeyang; Li, Zheng; Zheng, Xin; Qiu, Shang; Machuki, Jeremiah Ong’achwa; Zhang, Lijie; Yang, Yun; Guo, Kaijin; Gao, Fenglei

doi:10.1016/j.biomaterials.2021.121088

Cited by 55 publications

(45 citation statements)

References 52 publications

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“…It is a non-invasive treatment that involves local irradiation of the tumor using an external near-infrared (NIR) laser. Upon laser irradiation, the photothermal agent harvests light energy, converts it, and releases it as heat [ 8 , 9 ]. The subsequent temperature increase causes protein denaturation, cellular membrane disruption, enzyme dysfunction, and mitochondrial corruption, leading to tumor cell death and coagulative necrosis [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy

2022

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Background The outcome of phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT) for glioblastoma multiforme (GBM), is disappointing due to insufficient photoconversion efficiency and low targeting rate. The development of phototherapeutic agents that target GBM and generate high heat and potent ROS is important to overcome the weak anti-tumor effect. Results In this study, nanoconjugates composed of gold nanoparticles (AuNPs) and photosensitizers (PSs) were prepared by disulfide conjugation between Chlorin e6 (Ce6) and glutathione coated-AuNP. The maximum heat dissipation of the nanoconjugate was 64.5 ± 4.5 °C. Moreover, the proximate conjugation of Ce6 on the AuNP surface resulted in plasmonic crossover between Ce6 and AuNP. This improves the intrinsic ROS generating capability of Ce6 by 1.6-fold compared to that of unmodified-Ce6. This process is called generation of metal-enhanced reactive oxygen species (MERos). PEGylated-lactoferrin (Lf-PEG) was incorporated onto the AuNP surface for both oral absorption and GBM targeting of the nanoconjugate (denoted as Ce6-AuNP-Lf). In this study, we explored the mechanism by which Ce6-AuNP-Lf interacts with LfR at the intestinal and blood brain barrier (BBB) and penetrates these barriers with high efficiency. In the orthotopic GBM mice model, the oral bioavailability and GBM targeting amount of Ce6-AuNP-Lf significantly improved to 7.3 ± 1.2% and 11.8 ± 2.1 μg/kg, respectively. The order of laser irradiation, such as applying PDT first and then PTT, was significant for the treatment outcome due to the plasmonic advantages provided by AuNPs to enhance ROS generation capability. As a result, GBM-phototherapy after oral administration of Ce6-AuNP-Lf exhibited an outstanding anti-tumor effect due to GBM targeting and enhanced photoconversion efficiency. Conclusions The designed nanoconjugates greatly improved ROS generation by plasmonic crossover between AuNPs and Ce6, enabling sufficient PDT for GBM as well as PTT. In addition, efficient GBM targeting through oral administration was possible by conjugating Lf to the nanoconjugate. These results suggest that Ce6-AuNP-Lf is a potent GBM phototherapeutic nanoconjugate that can be orally administered. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy

2022

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“…79,80 For example, Gao et al synthesized the metal/semiconductor composite material Au NR@CuS. 81 The large octahedral void space could be used to load a large amount of drug methotrexate (MTX) for chemotherapy and modified with vasoactive intestinal peptide (VIP) and hyaluronic acid (HA) to form VIP-HA Au NR@CuS NPs targeting synovial cells in RA. Under laser irradiation, the integration of the Au NR and CuS semiconductor photocatalyst not only could generate heat but also introduce additional OH into photodynamic therapy (PDT).…”

Section: Stimulus-responsive Releasementioning

confidence: 99%

“…Huang et al also confirmed that drug-loaded NPs have a perfect drug loading performance and can load the drug MTX under different and the same pH conditions to control and release the drugs. 81 Guo et al also chose metal nanomaterials as drug carriers and used a metal-organic framework (MOF) as a nanocarrier to deliver MTX with an extremely high drug loading and simple and environmental preparation method. 91 Therefore, they combined MTX with tannic acid (TA) in the ratio of 2 : 1, after coordinating with the iron ion (Fe3 + ), reasonably designed MOFs, and then modified their surface with HA.…”

Section: Review Materials Advancesmentioning

confidence: 99%

Recent advances on drug delivery nanoplatforms for the treatment of autoimmune inflammatory diseases

et al. 2022

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“…Similarly, MNPs provide new avenues for osteoarthritis treatment owing to their excellent light responsiveness, strong plasticity, and self-anti-inflammatory properties. Huang et al ( Huang et al, 2021 ) reported a metal/semiconductor composite (Au NR@CuS) comprising octahedral Cu sulfide shell and Au nanorod core, loaded with vasoactive intestinal peptide and HA to form VIP–HA–Au NR@CuS NPs. It was experimentally demonstrated that the nanocomposite generated a photothermal effect under laser irradiation and introduced additional OH for PDT under the integration of a Fenton-like reaction and Au NR and CuS semiconductor photocatalysts; targeting synovial cells under the action of active intestinal peptides and HA, thereby exerting the combined effect of PTT, PDT, and CT, significantly removing the hyperplastic synovium, reducing joint inflammation symptoms.…”

Section: Application Scenarios Of Mnps In Bone Diseasesmentioning

confidence: 99%

Metal-based nano-delivery platform for treating bone disease and regeneration

Liu

Xu²,

Qiao³

et al. 2022

Front. Chem.

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Owing to their excellent characteristics, such as large specific surface area, favorable biosafety, and versatile application, nanomaterials have attracted significant attention in biomedical applications. Among them, metal-based nanomaterials containing various metal elements exhibit significant bone tissue regeneration potential, unique antibacterial properties, and advanced drug delivery functions, thus becoming crucial development platforms for bone tissue engineering and drug therapy for orthopedic diseases. Herein, metal-based drug-loaded nanomaterial platforms are classified and introduced, and the achievable drug-loading methods are comprehensively generalized. Furthermore, their applications in bone tissue engineering, osteoarthritis, orthopedic implant infection, bone tumor, and joint lubrication are reviewed in detail. Finally, the merits and demerits of the current metal-based drug-loaded nanomaterial platforms are critically discussed, and the challenges faced to realize their future applications are summarized.

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A multifunctional nano-therapeutic platform based on octahedral yolk-shell Au NR@CuS: Photothermal/photodynamic and targeted drug delivery tri-combined therapy for rheumatoid arthritis

Cited by 55 publications

References 52 publications

A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy

A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy

Recent advances on drug delivery nanoplatforms for the treatment of autoimmune inflammatory diseases

Metal-based nano-delivery platform for treating bone disease and regeneration

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