A Multifunctional Micellar Nanoplatform with pH‐Triggered Cell Penetration and Nuclear Targeting for Effective Cancer Therapy and Inhibition to Lung Metastasis

Jing, Yuting; Xiong, Xiang‐Yuan; Ming, Yang; Zhao, Jingya; Guo, Xing; Yang, Guang; Zhou, Shaobing

doi:10.1002/adhm.201700974

Cited by 41 publications

(20 citation statements)

References 45 publications

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“…Using a tumor-targeted RGD peptide moiety, the negatively charged HCPT was efficiently transported to the nucleus to exert its activity. In another piece of work for HCPT delivery, Zhou's group constructed a multifunctional micellar nanoplatform, namely PECL/DA-TAT, for TAT peptidemediated nucleus-localization of HCPT (Jing et al, 2018). As a consequence, the treatment obtained satisfying therapeutic efficiency both in vitro and in vivo.…”

Section: Nucleus-targeted Cancer Therapymentioning

confidence: 99%

Peptide-Decorated Supramolecules for Subcellular Targeted Cancer Therapy: Recent Advances

et al. 2020

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Binding small molecules through non-covalent molecular forces affords supramolecules, such as hydrogen bonds, with electrostatic, π-π interactions, van der Waals forces, and hydrophobic effects. Due to their good biocompatibility, low immunogenicity, and biodegradability, supramolecules have been intensely studied as multifunctional drug delivery platforms in targeted cancer therapy. In consideration of the defective therapeutic efficacy induced by simply transporting the therapeutic agents into tumor tissues or cancer cells instead of subcellular organelles, research is progressing toward the development of subcellular targeted cancer therapy (STCT) strategies. STCT is one of the most recent developments in the field of cancer nanomedicine. It is defined as the specific transportation of therapeutic agents to the target organelles for cancer treatment, which makes therapeutic agents accumulate in the target organelles at higher concentrations than other subcellular compartments. Compared with tumor-targeted and cancer-cell-targeted therapies, STCT exhibits dramatically improved specificity and precision, diminished adverse effects, and enhanced capacity to reverse multidrug resistance (MDR). Over the past few decades, peptides have played increasingly essential roles in multi-types of tumor-targeted drug delivery systems. Moreover, peptide-mediated STCT is becoming an emerging approach for precision cancer therapy and has been used in various cancer treatments, such as photothermal therapy (PTT), photodynamic therapy (PDT), chemotherapy, gene therapy, and non-drug-loaded nanoassemblies. In this review, we will focus on recent innovations in the variety of peptides used in designing peptide-decorated supramolecules for cell-membrane-, mitochondria-, and nucleus-localized STCT.

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Section: Nucleus-targeted Cancer Therapymentioning

confidence: 99%

Peptide-Decorated Supramolecules for Subcellular Targeted Cancer Therapy: Recent Advances

et al. 2020

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“…Tremendous efforts had been devoted to the development of stimuli-responsive tumor-targeted drug delivery systems to deal with aforementioned dilemma. On one hand, pH-dependent charge conversion strategy is utilized to construct polymeric drug, which maintains their stealth features during circulation and then undergoes a charge reversal process for achieving enhanced tumor cells' internalization once exposed to tumor relative acidic environment [15][16][17][18]. On the other hand, polymeric drug with ROS generation capability will be an effective approach to copying with insufficient ROS concentration for activating the complete drug release [13][14][15]19].…”

Section: Introductionmentioning

confidence: 99%

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

et al. 2020

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Background The enhancement of tumor retention and cellular uptake of drugs are important factors in maximizing anticancer therapy and minimizing side effects of encapsulated drugs. Herein, a delivery nanoplatform, armed with a pH-triggered charge-reversal capability and self-amplifiable reactive oxygen species (ROS)-induced drug release, is constructed by encapsulating doxorubicin (DOX) in pH/ROS-responsive polymeric micelle. Results The surface charge of this system was converted from negative to positive from pH 7.4 to pH 6.8, which facilitated the cellular uptake. In addition, methionine-based system was dissociated in a ROS-rich and acidic intracellular environment, resulting in the release of DOX and α-tocopheryl succinate (TOS). Then, the exposed TOS segments further induced the generation of ROS, leading to self-amplifiable disassembly of the micelles and drug release. Conclusions We confirms efficient DOX delivery into cancer cells, upregulation of tumoral ROS level and induction of the apoptotic capability in vitro. The system exhibits outstanding tumor inhibition capability in vivo, indicating that dual stimuli nano-system has great potential to function as an anticancer drug delivery platform.

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“…Tremendous efforts had been devoted to the development of stimuli-responsive tumor-targeted drug delivery systems to deal with aforementioned dilemma. On one hand, pH-dependent charge conversion strategy is utilized to construct polymeric drug, which maintains their stealth features during circulation and then undergoes a charge reversal process for achieving enhanced tumor cells' internalization once exposed to tumor relative acidic environment [15][16][17][18] . On the other hand, polymeric drug with ROS generation capability will be an effective approach to copying with insu cient ROS concentration for activating the complete drug release [13][14][15]19] .…”

Section: Introductionmentioning

confidence: 99%

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

Zhang

Zhu

Miao

et al. 2020

Preprint

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Background: The enhancement of tumor retention and cellular uptake of drugs are important factors in maximizing anticancer therapy and minimizing side effects of encapsulated drugs. Herein, a delivery nanoplatform, armed with a pH-triggered charge-reversal capability and self-amplifiable reactive oxygen species (ROS)-induced drug release, is constructed by encapsulating doxorubicin (DOX) in pH/ROS-responsive polymeric micelle. Results: The surface charge of this system was converted from negative to positive from pH 7.4 to pH 6.8, which facilitated the cellular uptake. In addition, methionine-based system was dissociated in a ROS-rich and acidic intracellular environment, resulting in the release of DOX and α-tocopheryl succinate (TOS). Then, the exposed TOS segments further induced the generation of ROS, leading to self-amplifiable disassembly of the micelles and drug release. Conclusions: We confirms efficient DOX delivery into cancer cells, upregulation of tumoral ROS level and induction of the apoptotic capability in vitro . The system exhibits outstanding tumor inhibition capability in vivo , indicating that dual stimuli nano-system has great potential to function as an anticancer drug delivery platform.

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A Multifunctional Micellar Nanoplatform with pH‐Triggered Cell Penetration and Nuclear Targeting for Effective Cancer Therapy and Inhibition to Lung Metastasis

Cited by 41 publications

References 45 publications

Peptide-Decorated Supramolecules for Subcellular Targeted Cancer Therapy: Recent Advances

Peptide-Decorated Supramolecules for Subcellular Targeted Cancer Therapy: Recent Advances

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

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