A Multifunctional Dental Resin Composite with Sr-N-Doped TiO2 and n-HA Fillers for Antibacterial and Mineralization Effects

Zhao, Yuanhang; Zhang, Hong; Liang, Hong; Zou, Xinying; Song, Jiazhuo; Han, Rong; Chen, Jiawen; Yu, Yiyan; Liu, Xin; Zhao, Hong; Zhang, Zhimin

doi:10.3390/ijms24021274

Cited by 6 publications

(6 citation statements)

References 71 publications

(70 reference statements)

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“…Therefore, both composites were subjected to MSC proliferation aiming at the assessment of biocompatibility and evidence of cytotoxic effects. It is assumed that small differences in the mineral filler ratio might significantly influence the composites’ biologic behavior, in good agreement with the literature [ 40 , 41 ]. The null hypothesis states that a small difference in mineral filler has no influence on the composites’ bioactivity in vitro.…”

Section: Introductionsupporting

confidence: 84%

In Vitro Study of Composite Cements on Mesenchymal Stem Cells of Palatal Origin

Ardelean

Dragomir

Moldovan

et al. 2023

IJMS

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Uniform filler distribution in composites is an important requirement. Therefore, BaO glass, nano hydroxyapatite and quartz filler distribution was realized through PCL microcapsules which progressively release filler during matrix polymerization. Two composites were realized based on a complex matrix containing BisGMA, UDMA, HEMA and PEG400 mixed with a previously described mineral filler: 33% for C1 and 31% for C2. The spreading efficiency was observed via SEM, revealing a complete disintegration of the microcapsules during C1 polymerization, while C2 preserved some microcapsule parts that were well embedded into the matrix beside BaO filler particles; this was confirmed by means of the EDS spectra. Mesenchymal stem cells of palatal origin were cultured on the composites for 1, 3, 5 and 7 days. The alkaline phosphatase (ALP) level was measured at each time interval and the cytotoxicity was tested after 3, 5 and 7 days of co-culture on the composite samples. The SEM investigation showed that both composites allowed for robust proliferation of the cells. The MSC cell pluripotency stage was observed from 1 to 3 days with an average level of ALP of 209.2 u/L for C1 and 193.0 u/L for C2 as well as a spindle cell morphology. Cell differentiation occurred after 5 and 7 days of culture, implied by morphological changes such as flattened, star and rounded shapes, observed via SEM, which were correlated with an increased ALP level (279.4 u/L for C1 and 284.3 u/L for C2). The EDX spectra after 7 days of co-culture revealed increasing amounts of P and Ca close to the hydroxyapatite stoichiometry, indicating the stimulation of the osteoinductive behavior of MSCs by C1 and C2. The MTT assay test showed a cell viability of 98.08% for C1 and 97.33% for C2 after 3 days, proving the increased biocompatibility of the composite samples. The cell viability slightly decreased at 5 and 7 days but the results were still excellent: 89.5% for C1 and 87.3% for C2. Thus, both C1 and C2 are suitable for further in vivo testing.

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Section: Introductionsupporting

confidence: 84%

In Vitro Study of Composite Cements on Mesenchymal Stem Cells of Palatal Origin

Ardelean

Dragomir

Moldovan

et al. 2023

IJMS

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“…The development of a dental filling containing hydroxyapatite is also clinically relevant. The current literature indicates that such materials have antibacterial properties [ 23 , 24 ] and such compounds inhibit the formation of secondary caries located under the dental filling, caused by bacterial microleakage.…”

Section: Discussionmentioning

confidence: 99%

“…Domingo et al [ 20 ] found a 30% improvement in mechanical properties after adding HAp in the form of powder. In turn, Elkassas and Arafa [ 21 ] and Priyadarsini et al [ 22 ] confirmed that the addition of HAp on the nanometric scale improved to better understand the properties of composite materials containing hydroxyapatite fillers, and studies have examined the effect of hydroxyapatite treatment on selected mechanical properties [ 23 , 24 , 25 ]. One such property is hardness, which is easy to measure and comparable with other findings.…”

Section: Introductionmentioning

confidence: 99%

“…While existing studies on doping with hydroxyapatite have been based on composites based on TEGDMA, Bis-GMA, HEMA resins, and resin-modified glass ionomer cements [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ], the present paper examines the hydroxyapatite modification of a UDMA resin dental composite, which is used in restorative dentistry. This type of composite enables direct reconstruction of all cavities according to Black’s classification.…”

Section: Introductionmentioning

confidence: 99%

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An Evaluation of the Mechanical Properties of a Hybrid Composite Containing Hydroxyapatite

et al. 2023

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There is currently a lack of scientific reports on the use of composites based on UDMA resin containing HAp in conservative dentistry. The aim of this study was therefore to determine the effect of hydroxyapatite content on the properties of a hybrid composite used in conservative dentistry. This paper compares a commercial hybrid composite with experimental composites treated with 2% by weight (b/w), 5% b/w, and 8% b/w hydroxyapatite. The composites were subjected to bending strength, compression, and diametrical compression tests, as well as those for impact strength, hardness, and tribological wear. The obtained results were subjected to statistical analysis. Increased hydroxyapatite was found to weaken the mechanical properties; however, 2% b/w and 5% b/w hydroxyapatite powder was found to achieve acceptable results. The statistical analysis showed no significant differences. HAp is an effective treatment for composites when applied at a low concentration. Further research is needed to identify an appropriate size of HAp particles that can be introduced into a composite to adequately activate the surface and modification its composition.

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“…Numerous methods have been developed to inhibit or reduce the adhesion and colonization of bacterial biofilms, including physical mixing of antimicrobial agents with resin-based materials . The releasing-type antimicrobial agents, such as metal nanoparticles, − fluoride, , and chlorhexidine (CHX). Or contacting-type antimicrobial agents, like quaternary ammonium compounds (QACs) , and 2-methacryloyloxyethyl phosphorylcholine (MPC). , However, releasing-type antimicrobial agents are accompanied by the complete release of the antimicrobial agent, leading to a loss of antimicrobial efficacy.…”

Section: Introductionmentioning

confidence: 99%

Mechanical and Antimicrobial Properties of Boron Nitride/Methacrylic Acid Quaternary Ammonium Composites Reinforced Dental Flowable Resins

Wang,

Xiao,

et al. 2024

ACS Biomater. Sci. Eng.

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Dental resin composites (DRCs) are commonly used to restore teeth affected by dental caries or defects. These materials must possess excellent properties to withstand the complex oral environment. The objective of this study was to prepare and characterize Boron nitride nanosheets (BNN)/ dimethyl amino hexadecyl methacrylate (DMAHDM) composites (BNN/DMA), and to evaluate them as functional fillers to enhance the mechanical and antimicrobial properties of dental resins. The BNN/DMA composites were successfully prepared under the theoretical guidance of molecular dynamics (MD), and then the physicochemical and morphological characterization of the BNN/DMA composites were carried out by using various test methods, such as FT-IR, XRD, UV−vis spectroscopy, SEM, TEM, and AFM. It was doped into the dental flowable resin in a certain proportion, and the results showed that the flexural strength (FS), elastic modulus (EM), compressive strength (CS), and microhardness (MH) of the modified resin composites were increased by 53.29, 47.8, 97.59, and 37.1%, respectively, with the addition of 0.8 wt % of BNN/DMA composite fillers. It has a good inhibition effect on Streptococcus mutans, with an inhibition rate as high as 90.43%. Furthermore, this effect persists even after one month of aging. In conclusion, the modification of flowable resins with low-concentration BNN/DMA composites favorably integrates the mechanical properties and long-term antimicrobial activity of dental resins. At the same time, they have good biocompatibility and do not affect the aesthetics. The BNN/DMA composite modified flowable resin has the potential to become a new type of antimicrobial dental restorative material.

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A Multifunctional Dental Resin Composite with Sr-N-Doped TiO2 and n-HA Fillers for Antibacterial and Mineralization Effects

Cited by 6 publications

References 71 publications

In Vitro Study of Composite Cements on Mesenchymal Stem Cells of Palatal Origin

In Vitro Study of Composite Cements on Mesenchymal Stem Cells of Palatal Origin

An Evaluation of the Mechanical Properties of a Hybrid Composite Containing Hydroxyapatite

Mechanical and Antimicrobial Properties of Boron Nitride/Methacrylic Acid Quaternary Ammonium Composites Reinforced Dental Flowable Resins

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