A multifunctional black phosphorus-based adhesive patch intrinsically induces partial EMT for effective burn wound healing

Abstract

The ultimate goal of cutaneous wound healing is to reform a stratified epithelium to restore the normal epidermal barrier, which involves the epithelial-to-mesenchymal transition (EMT) process. However, the healing strategies...

Electroactive nanofibrous membrane with temperature monitoring for wound healing

“…Neovascularisation plays an essential role in the later stage of wound healing. 55,56 Immunohistochemical staining for CD31, a vascular endothelial cell differentiation and maturation marker, was used to evaluate neovascularization formation at the wound site. As shown in Fig.…”

Advanced Bioadhesive Hydrogels for Skin Care and Therapy

“…For instance, Wang et al have analyzed the efficacy of photothermal burn wound treatment using a catechol-conjugated chitosan and dextran-based hydrogel containing black phosphorus nanosheets. [135] Besides its robust tissue adhesiveness due to catechol functionalization, the encapsulated black phosphorus radiated heat upon NIR laser irradiation, which promoted a photothermal antibacterial effect against four main bacteria that often cause wound infection, Staphylococcus aureus, Escherichia coli, methicillin-resistant S. aureus, and Pseudomonas aeruginosa, without damaging the surrounding tissues. Accordingly, applying hydrogel to a cutaneous infectious burn wound model followed by NIR irradiation induced antiinflammation and rapid re-epithelialization, contributing to a remarkable wound closure rate and accelerated restoration of skin morphology and demonstrating the therapeutic significance in bioadhesive hydrogel-based PTT.…”

Roles of the HIF-1α pathway in the development and progression of keloids

“…The EMT has been reported to be ubiquitous in organ fibrosis and wound healing [ 117 , 118 ]. Wang et al [ 119 ] found that black phosphorus nanosheets (BPNSs), a new EMT-inducing system integrates, promoted burn wound healing by inducing EMT of epithelial cells through the Snail1-mediated signaling pathway. Recently, the change in the EMT was observed in the keloid tissues [ 120 ].…”