A multifuctional nanoplatform for drug targeted delivery based on radiation-engineered nanogels

Sabatino, Maria Antonietta; Ditta, Lorena Anna; Conigliaro, Alice; Dispenza, Clelia

doi:10.1016/j.radphyschem.2018.11.013

Cited by 9 publications

(11 citation statements)

References 67 publications

(48 reference statements)

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“…The impact of size, surface charge density, and surface chemistry on biodistribution, accumulation at the target site, and clearance have been the topic of several review papers [62][63][64][65][66][67]. One important consideration that emerges is that even subtle changes in the nanogel network can impact the biodistribution and tumor accumulation [68], as well as their cellular internalization mechanism, degree of uptake, and potential for toxicity [69,70].…”

Section: Biomedical Applications Of Bio-hybrid Nanogelsmentioning

confidence: 99%

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Micro- to Nanoscale Bio-Hybrid Hydrogels Engineered by Ionizing Radiation

2020

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Bio-hybrid hydrogels consist of a water-swollen hydrophilic polymer network encapsulating or conjugating single biomolecules, or larger and more complex biological constructs like whole cells. By modulating at least one dimension of the hydrogel system at the micro- or nanoscale, the activity of the biological component can be extremely upgraded with clear advantages for the development of therapeutic or diagnostic micro- and nano-devices. Gamma or e-beam irradiation of polymers allow a good control of the chemistry at the micro-/nanoscale with minimal recourse to toxic reactants and solvents. Another potential advantage is to obtain simultaneous sterilization when the absorbed doses are within the sterilization dose range. This short review will highlight opportunities and challenges of the radiation technologies to produce bio-hybrid nanogels as delivery devices of therapeutic biomolecules to the target cells, tissues, and organs, and to create hydrogel patterns at the nano-length and micro-length scales on surfaces.

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Section: Biomedical Applications Of Bio-hybrid Nanogelsmentioning

confidence: 99%

“…Either the carboxyl group or the amino group was used to bind bioactive molecules to the nanogel either directly or through a cleavable linker, as sketched in Figure 8. The other functional group has been used to bind a fluorescent label, when required [70].…”

Section: Nanogels In Cancer Therapymentioning

confidence: 99%

Micro- to Nanoscale Bio-Hybrid Hydrogels Engineered by Ionizing Radiation

2020

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“…In the past years, many studies have been realized on the formulations of these structures and two important approaches have been adopted [ 13 , 14 , 15 ]. On one side, it is possible to change the formulation of the core structure of nanogels, working with different polymers, tuning their quantities, and adopting a proper synthesis method to enhance the crosslinking degree [ 13 , 16 , 17 , 18 , 19 , 20 ]. Sabatino et al [ 13 ] demonstrated that with a proper selection of the irradiation conditions, polymer concentration, and gaseous atmosphere, nanogels with the desired features in terms of dimensions, surface electric charge, and chemical reactivity can be produced.…”

Section: Introductionmentioning

confidence: 99%

“…On one side, it is possible to change the formulation of the core structure of nanogels, working with different polymers, tuning their quantities, and adopting a proper synthesis method to enhance the crosslinking degree [ 13 , 16 , 17 , 18 , 19 , 20 ]. Sabatino et al [ 13 ] demonstrated that with a proper selection of the irradiation conditions, polymer concentration, and gaseous atmosphere, nanogels with the desired features in terms of dimensions, surface electric charge, and chemical reactivity can be produced. In particular, radiation-engineered poly ( N -vinyl pyrrolidone)-based nanogels bearing carboxyl groups and primary amines can be used as the main building block of promising nanodevices.…”

Section: Introductionmentioning

confidence: 99%

“…This kind of device was introduced for the first time by Vinogradov et al in 1999, describing a hydrophilic polymeric network obtained through crosslinking between polyethylene glycol (PEG) and polyethylenimine (PEI) [12]. In the past years, many studies have been realized on the formulations of these structures and two important approaches have been adopted [13][14][15]. On one side, it is possible to change the formulation of the core structure of nanogels, working with different polymers, tuning their quantities, and adopting a proper synthesis method to enhance the crosslinking degree [13,[16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels

Pinelli

Pizzetti

Ortolà

et al. 2020

IJMS

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In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volume to surface ratio, excellent drug loading and release ability, as well as biocompatibility and tunable behavior, are unique, and, nowadays, great efforts are made to develop new formulations that can be employed in a wider range of applications. Polyethylene glycol (PEG)-polyethylenimine (PEI) nanogels probably represent the baseline of this class of biomaterials and they are still largely employed and studied. In any way, the possibility to exploit new core formulations for nanogels is certainly very interesting in order to understand the influence of different polymer chains on the final properties of the system. In this research, we explore and make a comparison between PEG-PEI nanogels and two other different formulations: pluronic F127-PEI nanogels and PEG-Jeffamine nanogels. We propose nanogels synthesis methods, their chemical and physical characterization, as well as their stability analysis, and we focus on the different drug delivery ability that these structures exhibit working with different typologies of drug mimetics.

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