A multifaceted interplay between virulence, drug resistance, and the phylogeographic landscape of
Mycobacterium tuberculosis
Igor Mokrousov,
Tatiana Vinogradova,
Marine Dogonadze
et al.
Abstract:Latin-American Mediterranean (LAM) family is one of the most significant and global genotypes of
Mycobacterium tuberculosis
. Here, we used the murine model to study the virulence and lethality of the genetically and epidemiologically distinct LAM strains. The pathobiological characteristics of the four LAM strains (three drug resistant and one drug susceptible) and the susceptible reference strain H37Rv were studied in the C57BL/6 mouse model. The whole-genome sequencing was performed … Show more
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