A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration

Bai, Long; Du, Zhibin; Du, Jingjing; Yao, Weiqin; Zhang, Jiaming; Weng, Zeming; Liu, Si; Zhao, Ya; Liu, Yanlian; Zhang, Xiangyu; Huang, Xiaobo; Yao, Xiaohong; Crawford, Ross; Hang, Ruiqiang; Huang, Di; Tang, Bin; Xiao, Yin

doi:10.1016/j.biomaterials.2018.02.010

Cited by 221 publications

(156 citation statements)

References 84 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…Although the peaks seen in the composite are not as clear as the XRD of a pure HA, the characteristic peaks of HA are clearly visible at time 12 hours; the broad peak at 20° is almost undetected, while the sharp peak at 32° indicates that the HA is fully crystallized. The broad peak at 20° assigns to CS, and sharp diffraction peaks at 31.8 and 25.9 correspond to HA peaks …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

In situ biomimetic formation of nano‐hydroxyapatite crystals on chitosan microspheres

Huang

Niu

et al. 2019

Polymers for Advanced Techs

Self Cite

View full text Add to dashboard Cite

Chitosan (CS) is a biocompatible, noncytotoxic biomaterial used before as base material for composites. On the other hand, nano‐hydroxyapatite (nHA) is one of the main components of human bones, highly used for biomedical applications. In this work, CS microspheres were produced under a W/O emulsion system. CS microspheres with calcium ions were then exposed to Na3PO4 solution. In situ biomimetic nHA crystals were formed on CS microspheres to generate 15.14 ± 3.15‐μm composite microspheres. The microspheres were subsequently seeded with MG63 osteoblasts to observe their cell responses. All microspheres were characterized via scanning electron microscopy (SEM), phase‐contrast photomicroscopy, and X‐ray diffraction (XRD) analysis. The results showed flake‐like shape and islet‐like growth of nHA depositions presented on the surface of the CS microspheres. In vitro tests indicated that the CS/nHA microparticles were not only biocompatible but also enhanced cell adhesion and elongation due to the in situ biomimetic synthesis method.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The broad peak at 20°assigns to CS, and sharp diffraction peaks at 31.8 and 25.9 correspond to HA peaks. 9,16…”

Section: Compositional Analysismentioning

confidence: 99%

In situ biomimetic formation of nano‐hydroxyapatite crystals on chitosan microspheres

Huang

Niu

et al. 2019

Polymers for Advanced Techs

Self Cite

View full text Add to dashboard Cite

show abstract

“…6,7 Therefore, inhibiting the inflammatory response and reducing the release of proinflammatory cytokines are considered an effective strategy for preventing and treating wear debris-mediated periprosthetic osteolysis. [9][10][11] It has been reported that the regulation of macrophage polarization can mitigate wear debris-stimulated osteolysis. 8 Wear debris-stimulated M0 macrophages turn into proinflammatory macrophages (M1 phenotype) and subsequently produce of proinflammatory chemokines.…”

Section: Introductionmentioning

confidence: 99%

Curcumin has immunomodulatory effects on RANKL‐stimulated osteoclastogenesis in vitro and titanium nanoparticle‐induced bone loss in vivo

Yang

Zhu

Yuan

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…The increasing life expectancy and aging world population make the regeneration of bone defects a serious clinical challenge . Currently, orthopedic implantation is the most common treatment for bone defects . Benefited from good biocompatibility, corrosion resistance, light weight, and excellent mechanical properties, native titanium (Ti) and its alloys have been extensively used in orthopedics field .…”

Section: Introductionmentioning

confidence: 99%

“…1 Currently, orthopedic implantation is the most common treatment for bone defects. 2,3 Benefited from good biocompatibility, corrosion resistance, light weight, and excellent mechanical properties, native titanium (Ti) and its alloys have been extensively used in orthopedics field. [4][5][6] However, the inherent bioinertness and potential bacterial infection risk of bare Ti implants would weaken the osseointegration between bone tissue and implant surface, and even given rise to revision arthroplasty.…”

Section: Introductionmentioning

confidence: 99%

Preparing and immobilizing antimicrobial osteogenic growth peptide on titanium substrate surface

Liu

Yang

Tao

et al. 2018

J Biomedical Materials Res

View full text Add to dashboard Cite

The inherent bioinertness and potential bacterial infection risk are the two leading causes for Ti implant failure. To improve osseointegration and antibiosis, in this work, a novel antimicrobial osteogenic growth peptide was first synthesized by conjugating osteogenic growth peptide (OGP) and ciprofloxacin (CIP). Then, the synthetic antimicrobial peptide was immobilized onto Ti implant surface for chemoselective binding via the amide reaction. Thereafter, the capabilities of modified Ti implant on osseointegration and antibiosis were measured with cell experiments and antimicrobial activity in vitro. The results showed that antimicrobial osteogenic growth peptide (OGP-CIP) was successfully prepared and grafted onto Ti implant surface. Moreover, the antimicrobial peptide-modified Ti implants could promote osteoblasts spreading and osteodifferentiation compared with unmodified Ti substrates. Meanwhile, in vitro bacteria studies (Staphylococcus aureus and Escherichia coli) proved that the antibacterial property of antimicrobial peptide functionalized Ti implant was improved obviously. The method used in this work is a feasible and promising strategy to win the race against invading bacteria and accelerate bone integration in orthopedic implantation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3021-3033, 2018.

show abstract

A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration

Cited by 221 publications

References 84 publications

In situ biomimetic formation of nano‐hydroxyapatite crystals on chitosan microspheres

In situ biomimetic formation of nano‐hydroxyapatite crystals on chitosan microspheres

Curcumin has immunomodulatory effects on RANKL‐stimulated osteoclastogenesis in vitro and titanium nanoparticle‐induced bone loss in vivo

Preparing and immobilizing antimicrobial osteogenic growth peptide on titanium substrate surface

Contact Info

Product

Resources

About