“…Reports have shown that incidence rate of glaucoma is higher in siblings compared with unrelated controls, indicating an important role of host genetics in predisposition to glaucoma. Recent genome wide association studies reveled role of ATP‐binding cassette transporter A1, actin filament‐associated protein 1, GDP‐mannose 4,6 dehydratase, phosphomannomutase 2, transforming growth factor beta receptor III, fibronectin type III domain containing 3B, rho guanine nucleotide exchange factor 12, growth arrest‐specific protein 7, forkhead box C1, ataxin‐2, thioredoxin reductase 2 with POAG, and PACG showed to be linked to ependymin related 1, choline acetyltransferase, gli‐similar protein 3, fermitin family member 2, and dolichyl‐phosphate mannosyltransferase subunit 2 . Furthermore, various candidate gene association studies presented association of single nucleotide polymorphisms with predisposition to development of POAG or PACG.…”