A multidisciplinary assessment of pain in juvenile idiopathic arthritis

Upadhyay, Jaymin; Lemme, Jordan; Cay, Mariesa; Heijden, Hanne Van Der; Sibai, Diana; Goodlett, Benjamin D.; Lo, Jeffery; Hoyt, Kacie J.; Taylor, Maria; Hazen, Melissa; Halyabar, Olha; Meidan, Esra; Schreiber, Rudy; Chang, Margaret H.; Nigrović, Peter A.; Jaimes, Camilo; Henderson, Lauren A.; Ecklund, Kirsten; Sundel, Robert P.

doi:10.1016/j.semarthrit.2021.05.011

Cited by 9 publications

(9 citation statements)

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“…Our recent investigation utilizing the same JIA patient sample identified a significant association between caudate volume and clinical pain intensity ratings as well as a significant correlation between cortical thickness of the insula cortex and ESR values [ 27 ]. Therefore, the relationship, or lack thereof, between Pain-associated proteins described above and morphological properties of the caudate nucleus and insula were explored.…”

Section: Resultsmentioning

confidence: 99%

“…In prior work, JIA patients were shown to harbor altered CNS properties. Specifically, caudate nucleus volume was negatively correlated to clinical pain intensity and decreased cortical thickness of the insula was not only observed to be lower in JIA patients relative to controls, but also showed a negative correlation with ESR values [ 27 ]. Besides a role of the caudate nucleus in the motor system, it has also been proposed to play an important part in modulation of pain experience [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…1 ). This cohort was described in our prior report [ 27 ]. Patients were recruited from the Rheumatology Program at Boston Children’s Hospital (BCH), following approval of the BCH Institutional Review Board.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, JIA patients were also evaluated with non-contrast MRI to detect possible bone erosion, cartilage degradation, joint space narrowing, bone marrow edema, soft-tissue edema, joint fluid, synovitis, and tenosynovitis. Each musculoskeletal MRI dataset was assessed by a board-certified pediatric radiologist (Dr. Ecklund).’ ESR values were available for 13 out of the 16 patients, while combined neuroimaging and musculoskeletal MRI analyses were performed as previously described in nine out of the 16 patients [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

“…In the current report, an LC/MS-based proteomics analysis of blood serum samples was performed to identify proteins that associate with clinical pain severity in a cohort of JIA patients. Subsequently, the association was examined between pain-associated proteins and other aspects of JIA, such as erythrocyte sedimentation rate (ESR), clinical juvenile arthritis disease activity score (cJADAS) [ 26 ], and CNS morphological properties previously implicated in JIA [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis

et al. 2022

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Introduction Juvenile idiopathic arthritis (JIA) is a cluster of autoimmune rheumatic diseases occurring in children 16 years of age or less. While it is well-known that pain may be experienced during inflammatory and non-inflammatory states, much remains ambiguous regarding the molecular mechanisms that may drive JIA pain. Thus, in this pilot study, we explored the variability of the serum proteomes in relation to pain severity in a cohort of JIA patients. Methods Serum samples from 15 JIA patients (male and female, 12.7 ± 2.8 years of age) were assessed using liquid chromatography/mass spectrometry (LC/MS). Correlation analyses were performed to determine the relationships among protein levels and self-reported clinical pain severity. Additionally, how the expression of pain-associated proteins related to markers of inflammation (Erythrocyte Sedimentation Rate (ESR)) or morphological properties of the central nervous system (subcortical volume and cortical thickness) implicated in JIA were also evaluated. Results 306 proteins were identified in the JIA cohort of which 14 were significantly (p < 0.05) associated with clinical pain severity. Functional properties of the identified pain-associated proteins included but were not limited to humoral immunity (IGLV3.9), inflammatory response (PRG4) and angiogenesis (ANG). Associations among pain-associated proteins and ESR (IGHV3.9, PRG4, CST3, VWF, ALB), as well as caudate nucleus volume (BTD, AGT, IGHV3.74) and insular cortex thickness (BTD, LGALS3BP) were also observed. Conclusions The current proteomic findings suggest both inflammatory- and non-inflammatory mediated mechanisms as potential factors associated with JIA pain. Validation of these preliminary observations using larger patient cohorts and a longitudinal study design may further point to novel serologic markers of pain in JIA.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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