A Multidisciplinary Approach to the Study of T Cell Migration

Hertoghe, T

doi:10.1196/annals.1322.035

Cited by 58 publications

(27 citation statements)

References 4 publications

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“…Further, although the correction of all hormonal defi cits by an adequate multiple hormone replacement therapy, is not currently possible, hormone therapy does constitute a viable solution to prevent and treat most hormonal defi cits due to pathological aging. Hertogue (2005) recently reported that even though we are not presently able to abrogate senescence by hormone treatments because of the unavailability as medications of all hormones that decline with age, the future appears promising.…”

Section: Discussionmentioning

confidence: 99%

“…The elderly have demonstrated signifi cantly lower levels of production of most hormones compared to young adults (Hertogue 2005). There is a voluminous body of scientifi c literature concerned with hormonal defi cits with aging.…”

Section: Hormonesmentioning

confidence: 99%

“…There is a voluminous body of scientifi c literature concerned with hormonal defi cits with aging. That is, levels of growth hormone (GH) and insulin like growth factor-1 (IGF-1), melatonin (nocturnal), TSH, thyroid hormones (T3), calcitonin, DHEA (sulphated form in and its urinary 17-keto-metabolites), aldosterone, estrogens, testosterone in men and women have been demonstrated to progressively decrease with age in adults (for extensive review and individual references refer Hertogue 2005).…”

Section: Hormonesmentioning

confidence: 99%

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Lifestyle and nutrition, caloric restriction, mitochondrial health and hormones: Scientific interventions for anti-aging

Anton¹

2008

CIA

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Aging is a universal process to all life forms. The most current and widely accepted defi nition for aging in humans is that there is a progressive loss of function and energy production that is accompanied by decreasing fertility and increasing mortality with advancing age. The most obvious and commonly recognised consequence of aging and energy decline is a decrease in skeletal muscle function which affects every aspect of human life from the ability to play games, walk and run to chew, swallow and digest food. There is hence a recognised overall decline of an individuals' fi tness for the environment that they occupy. In Westernised countries this decline is gradual and the signs become mostly noticeable after the 5th decade of life and henceforth, where the individual slowly progresses to death over the next three to four decades. Given that the aging process is slow and gradual, it presents with opportunities and options that may ameliorate and improve the overall functional capacity of the organism. Small changes in function may be more amenable and likely to further slow down and possibly reverse some of the deleterious effects of aging, rather, than when the incremental changes are large. This overall effect may then translate into a signifi cant compression of the deleterious aspects of human aging with a resultant increase in human life expectancy.

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Section: Discussionmentioning

confidence: 99%

Section: Hormonesmentioning

confidence: 99%

Section: Hormonesmentioning

confidence: 99%

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Lifestyle and nutrition, caloric restriction, mitochondrial health and hormones: Scientific interventions for anti-aging

Anton¹

2008

CIA

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“…The aging of hypothalamic-pituitary axis leads to progressive functional loss and gradually develops into endocrine deficiency [43].…”

Section: Journal Of Medical Toxicology and Clinical Forensic Medicinementioning

confidence: 99%

The Propolis Effect on Chlorpyrifos Induced Thyroid Toxicity in Male Albino Rats

El-Sheikh¹,

Ibrahim²

2017

J Med Toxicol Clin Forens Med

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Chlorpyrifos (CPF) is a chlorinated organophosphate insecticide that is used widely in the world and Egypt. The aim of present work was to study the possible protective role of Propolis on thyroid gland of male rats after chronic exposure of chlorpyrifos. For this purpose, Fifty adult male albino rats were randomized into 5 groups: I, II (Control), III (received Propolis dissolved in 0.5 ml corn oil, 50 mg/kg b.w./day), IV (received CPF dissolved in 0.5 ml corn oil 6.75 mg/kg b.w./ day) and V (received CPF and Propolis at the same previously mentioned doses). Rats were orally treated by gavage for 12 weeks. We found that Chlorpyrifos induced damaging effects in thyroid tissue architecture, thickened collagen fibers between the follicles and decreased periodic acid schiff (PAS) reaction in the colloids. Immunohistochemically, there was weak thyroglobulin (TGB) expression. Besides, it significantly decreased the serum levels of Tri-iodothyronin (T3), Tetraiodothyronin (T4) and Thyroid stimulating hormone (TSH). It depressed reduced glutathione (GSH) content and antioxidant enzyme activities in thyroid tissues with respect to control groups. Furthermore, CPF increased thyroid oxidative stress as manifested by elevated malondialdehyde (MDA) levels. On the other hand, the concurrent administration of Propolis with CPF showed significant improvement in previous changes. Our findings showed that the concurrent oral administration of Propolis with CPF improved the CPF induced oxidative damaging effects in thyroid gland and the antioxidative defense in the rats.

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“…Research on aging in laboratory rodents (e.g., Sapolsky et al, 1986) and humans (e.g., Lupien et al, 1998;Hertoghe, 2004;Otte et al, 2005) has focused heavily on the deterioration of the HPA axis as a key integrator of numerous physiological functions (Fig. 1).…”

Section: Growing Old In the Boreal Forestmentioning

confidence: 99%

Equipped for Life in the Boreal Forest: The Role of the Stress Axis in Mammals

Boonstra¹,

Dantzer²,

Delehanty³

et al. 2014

ARCTIC

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ABSTRACT. The hypothalamic-pituitary-adrenal axis (stress axis) plays a central role in equipping mammals to succeed in the challenging environment of the boreal forest. Over the last 20 years, we have tackled a broad range of topics to understand how the stress axis functions in four key herbivore species. The central challenge for snowshoe hares is coping with their predators, whereas for the others, it is primarily coping with each other (especially during reproduction) and with their physical environment. Hares are severely stressed by their predators during the population decline. The predator threat causes major changes in the stress axis of hares and reduces their reproduction; in addition, acting through maternal programming, it is the most plausible explanation for the extended period of low numbers following the population decline. Arctic ground squirrel males have an intense breeding season for two to three weeks in early spring, after which many of them die. The functioning of their stress axis changes markedly and is key in meeting their energy demands during this period. In contrast, red-backed vole males, though also short-lived, breed repeatedly only in the summer of their life, and their stress axis shows no change in function. However, their reproductive effort negatively affects their long-term survival. Territorial red squirrels experience marked interannual fluctuations in their major food source (white spruce seed), resulting in major fluctuations in their densities and consequently in the intensity of territorial competition. Changes in the densities of red squirrels also alter maternal stress hormone levels, inducing adaptive plasticity in offspring postnatal growth rates that prepares offspring for the environment they will encounter at independence. To survive winter, red squirrels need to defend their territories year-round, and the basis of this defense appears to be adrenal dehydroepiandrosterone, which has the benefits, but not the costs, of gonadal steroids. Arctic ground squirrels survive winter by hibernating in deeply frozen ground. Unlike all other hibernators, they have evolved a unique adaptation: high levels of adrenal androgens in summer to accumulate protein reserves that they then burn in winter. With a rapidly changing climate, the stress axis will play a key role in permitting northern animals to adapt, but the linkages between the changes in the abiotic and biotic components of the boreal forest and the phenotypic plasticity in the stress response of its inhabitants are not well understood for these or any other herbivore species.Key words: stress axis, maternal programming, predation risk, hibernation, life history, longevity, territoriality, DHEA, adrenal androgens, snowshoe hare cycle RÉSUMÉ. L'axe hypothalamo-hypophyso-surrénalien (l'axe du stress) joue un rôle central pour aider les mammifères à réussir dans l'environnement difficile de la forêt boréale. Ces 20 dernières années, nous nous sommes penchés sur une vaste gamme de sujets afin de comprendre comment fonc...

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A Multidisciplinary Approach to the Study of T Cell Migration

Cited by 58 publications

References 4 publications

Lifestyle and nutrition, caloric restriction, mitochondrial health and hormones: Scientific interventions for anti-aging

Lifestyle and nutrition, caloric restriction, mitochondrial health and hormones: Scientific interventions for anti-aging

The Propolis Effect on Chlorpyrifos Induced Thyroid Toxicity in Male Albino Rats

Equipped for Life in the Boreal Forest: The Role of the Stress Axis in Mammals

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