A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties

Zhang, Yiwen; Li, Saiyu; Yang, Panpan; Zhang, Qian; Xu, Huarong; Bi, Kaishun; Li, Qing

doi:10.1016/j.phymed.2022.154273

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…Phase II metabolism of organic acids was also detected in brain tissue, mainly through the sulfation reaction to generate p ‐hydroxycinnamic acid + 2H + sul and ethyl gallate + sul. Based on the strategy of ingredients pointed at lesions, [ 24 ] a total of eight organic acids infiltrated BBB were figured out in rat brains, which might be the potential active material in WKOA.…”

Section: Resultsmentioning

confidence: 99%

Screening of the Active Substances for the Assessment of Walnut Kernel in the Treatment of Scopolamine‐Induced AD Animals

Xu,

Song,

Jiang

et al. 2023

Molecular Nutrition Food Res

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ScopeAlzheimer's disease (AD) has been a challenge and hotspot in the field of neuroscience research due to the high morbidity. As we all know, walnut kernel (WK) ingestion has been linked to benefits to brain health and has the function of improving memory. This study follows the AD model induced by scopolamine to reveal the active fractions and substances of walnut in the treatment of AD.Methods and resultsThe histopathological analysis and brain tissue biochemistry assay are revealed the active fractions of WK, and this result determines that walnut kernel organic acids have significant therapeutic effect on AD. The strategy of studying ingredients pointed at lesions is integrated to ascertain the selected brain‐targeted effective substances of WK for blood–brain barrier by ultra‐performance liquid chromatography‐quadrupole/electrostatic field orbitrap mass spectrometry, and a total of eight organic acids are figured out definite absorptivity in rat brains. Finally, the binding interaction between the effective substances and target proteins is analyzed by molecular docking, and the main function related active markers are ascertained as glansreginin A, glansreginic acid, ellagic acid, and ellagic acid 4‐O‐xyloside.ConclusionsThe comprehensive process is helpful to the clinical application of WK as a promising cholinesterase inhibitors for nutritional intervention.

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Section: Resultsmentioning

confidence: 99%

Screening of the Active Substances for the Assessment of Walnut Kernel in the Treatment of Scopolamine‐Induced AD Animals

Xu,

Song,

Jiang

et al. 2023

Molecular Nutrition Food Res

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“…Meanwhile, researchers found that the total amount of nine lignans in S. chinensis collected from Heilongjiang and Liaoning provinces was significantly higher than that from other regions, indicating that the geographic environment in Northeast China is more suitable for the growth of S. chinensis ( 89 ). A study in 2022 analyzed 14 preparations of S. chinensis by HPLC fingerprinting combined with multiple chemometric methods and discovered that schisandrin A, besides the four components mentioned above, could also be used as a comprehensive marker for quality control of S. chinensis ( 90 ).…”

Section: Nutritional and Active Components Of Schisandra Ch...mentioning

confidence: 99%

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Jia¹,

Li²,

Lou³

et al. 2023

Front. Nutr.

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ObjectiveSchisandra chinensis (Turcz.) Baill. (S. chinensis) is a Traditional Chinese medicinal herb that can be used both for medicinal purposes and as a food ingredient due to its beneficial properties, and it is enriched with a wide of natural plant nutrients, including flavonoids, phenolic acids, anthocyanins, lignans, triterpenes, organic acids, and sugars. At present, there is lack of comprehensive study or systemic characterization of nutritional and active ingredients of S. chinensis using innovative mass spectrometry techniques.MethodsThe comprehensive review was conducted by searching the PubMed databases for relevant literature of various mass spectrometry techniques employed in the analysis of nutritional components in S. chinensis, as well as their main nutritional effects. The literature search covered the past 5 years until March 15, 2023.ResultsThe potential nutritional effects of S. chinensis are discussed, including its ability to enhance immunity, function as an antioxidant, anti-allergen, antidepressant, and anti-anxiety agent, as well as its ability to act as a sedative-hypnotic and improve memory, cognitive function, and metabolic imbalances. Meanwhile, the use of advanced mass spectrometry detection technologies have the potential to enable the discovery of new nutritional components of S. chinensis, and to verify the effects of different extraction methods on these components. The contents of anthocyanins, lignans, organic acids, and polysaccharides, the main nutritional components in S. chinensis, are also closely associated to its quality.ConclusionThis review will provide guidelines for an in-depth study on the nutritional value of S. chinensis and for the development of healthy food products with effective components.

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“…Due to the widespread use of antimicrobial drugs, antimicrobial resistance levels are increasing worldwide ( World Health Organization, 2022 ). It is worth noting that as the concentration of antibacterial drugs increases in environments such as in water and in agriculture farms, multi-drug-resistant (MDR: resistant to ≥ one agent in ≥3 antimicrobial classes) genes are emerging in Infrequently Isolated or Fastidious Bacteria ( Zhang et al, 2022 ; Yang and Wu, 2023 ). Many reports have demonstrated that antimicrobial-resistant Infrequently Isolated or Fastidious Bacteria are increasingly occurring in the environment ( Gonzalez-Avila et al, 2021 ; Algammal et al, 2022a ; Wu et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Practice of standardization of CLSI M45 A3 antimicrobial susceptibility testing of Infrequently Isolated or Fastidious Bacteria strains isolated from blood specimens in Guangdong Province 2017–2021

He,

Yang,

Haque

et al. 2024

Front. Microbiol.

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The concentration of antimicrobial agents in environments like water and food has increased rapidly, which led to a rapid increase in antimicrobial resistance levels in the environment. Monitoring of bacterial resistance levels is considered as a necessary means to control the bacterial resistance. Reference standards are critical for antimicrobial susceptibility testing. CLSI M45 A3 standard defines pathogenic microorganisms that cause infections less frequently than those covered by CLSI M02, M07, and M100 as Infrequently Isolated or Fastidious Bacteria and specifies antimicrobial susceptibility testing methods. Our study investigated the epidemiology and antimicrobial susceptibility testing data of Infrequently Isolated or Fastidious Bacteria strains isolated from blood specimens in 70 hospitals in Guangdong Province between 2017 and 2021. We defined testing methods other than those specified in CLSI M45 A3 as “Non-Standardized.” The proportion of standardized antimicrobial susceptibility testing for penicillin increased significantly (Corynebacterium spp. 17.4% vs. 50.0% p < 0.05; Micrococcus spp. 50.0% vs. 77.8% p < 0.05; Abiotrophia spp. and Granulicatella spp. 21.4% vs. 90.9% p < 0.001), while for cefotaxime (Corynebacterium spp. 0.0% vs. 45.2% p < 0.05; Abiotrophia spp. and Granulicatella spp. 0.0% vs. 14.3% p = 0.515) and vancomycin increased finitely. Non-standardized methods were used for all other antimicrobials. Due to limitations in the economic and medical environment, some clinical laboratories are unable to fully comply with CLSI M45 A3 standard. We recommend that CLSI should add breakpoints for disk diffusion method to improve the standardization of antimicrobial susceptibility testing.

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A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties

Cited by 7 publications

References 25 publications

Screening of the Active Substances for the Assessment of Walnut Kernel in the Treatment of Scopolamine‐Induced AD Animals

Screening of the Active Substances for the Assessment of Walnut Kernel in the Treatment of Scopolamine‐Induced AD Animals

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Practice of standardization of CLSI M45 A3 antimicrobial susceptibility testing of Infrequently Isolated or Fastidious Bacteria strains isolated from blood specimens in Guangdong Province 2017–2021

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