A Multidimensional Cross-Sectional Analysis of Coronavirus Disease 2019 Seroprevalence Among a Police Officer Cohort: The PoliCOV-19 Study

Sendi, Parham; Baldan, Rossella; Thierstein, Marc; Widmer, Nadja; Gowland, Peter; Gahl, Brigitta; Buechi, Annina E; Guentensperger, Dominik; Wider, Manon; Blum, Manuel R.; Tinguely, Caroline; Maillat, Cédric; Theel, Elitza S.; Berbari, Elie F.; Dijkman, Ronald; Niederhauser, Christoph

doi:10.1093/ofid/ofab524

Cited by 4 publications

(20 citation statements)

References 27 publications

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“…The presence or absence of seroconversion between the baseline and 3‐month visit was investigated in 956 paired samples, and between the 3‐ and 6‐month visits in 955 paired samples. The seroprevalences of anti‐NCP antibodies—without adjusting for paired sample results or false positive or false negative results—were 12.9% at baseline, 5 14.4% at the 3‐month visit, and 15.3% at the 6‐month visit (Appendices, Figure S2 ).…”

Section: Resultsmentioning

confidence: 99%

“…In our cohort, the seroprevalence at the baseline was 12.9% in February 2021, similar to that reported in the general population. 5 The self‐reported compliance with mask‐wearing during working hours was very high. The results suggested that household contacts were the leading transmission venues.…”

Section: Discussionmentioning

confidence: 99%

“…The study protocol is aligned with that of the World Health Organization (WHO) for population‐based age‐stratified seroepidemiological investigations, 6 adapted for the specific population and geographic region in our study. The population involved in the PoliCOV‐19 study has been published previously, 5 and included after 6 months 1022 study participants (Appendices, Figure S1 ).…”

Section: Methodsmentioning

confidence: 99%

“…The baseline investigation was performed in January/February and published elsewhere. 5 The 3‐month follow‐up visit was performed in April/May, and the 6‐month follow‐up in September 2021 (Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…4 The seroprevalence of anti‐nucleocapsid antibodies in the police cohort before initiating a vaccine program was 12.9%. 5 In March 2021, a vaccination campaign for their employees was promoted by the Cantonal Police Bern. Here, we present the COVID‐19 infection and vaccination rate 3 and 6 months after initiating the cohort, and the dynamics of antispike antibody levels in vaccinated individuals.…”

Section: Introductionmentioning

confidence: 99%

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Serosurveillance after a COVID‐19 vaccine campaign in a Swiss police cohort

Sendi

Thierstein

Widmer

et al. 2022

Immunity Inflam & Disease

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Introduction To assess the risk for COVID‐19 of police officers, we are studying the seroprevalence in a cohort. The baseline cross‐sectional investigation was performed before a vaccination campaign in January/February 2021, and demonstrated a seroprevalence of 12.9%. Here, we demonstrate serosurveillance results after a vaccination campaign. Methods The cohort consists of 1022 study participants. The 3‐ and 6‐month follow‐up visits were performed in April/May and September 2021. Data on infection and vaccination rates were obtained via measuring antibodies to the nucleocapsid protein and spike protein and online questionnaires. Results The mean age of the population was 41 ( SD 8.8) years, 72% were male and 76% had no comorbidity. Seroconversion was identified in 1.05% of the study population at the 3‐month visit and in 0.73% at the 6‐month visit, resulting in an infection rate of 1.8% over a time period of 6 months. In comparison, the infection rate in the general population over the same time period was higher (3.18%, p = .018). At the 6‐month visit, 77.8% of participants reported being vaccinated once and 70.5% twice; 81% had an anti‐S antibody titer of >250 U/ml and 87.1% of ≥2 U/ml. No significant association between infection and job role within the department, working region, or years of experience in the job was found. Anti‐spike antibody titers of vaccinated study participants showed a calculated decreasing trend 150–200 days after the second vaccine dose. Conclusion These data confirm the value of the vaccination campaign in an exposed group other than healthcare professionals.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serosurveillance after a COVID‐19 vaccine campaign in a Swiss police cohort

Sendi

Thierstein

Widmer

et al. 2022

Immunity Inflam & Disease

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Do quantitative levels of antispike‐IgG antibodies aid in predicting protection from SARS‐CoV‐2 infection? Results from a longitudinal study in a police cohort

Sendi

Widmer

Branca

et al. 2023

Journal of Medical Virology

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In a COVID-19 sero-surveillance cohort study with predominantly healthy and vaccinated individuals, the objectives were (i) to investigate longitudinally the factors associated with the quantitative dynamics of antispike (anti-S1) IgG antibody levels, (ii) to evaluate whether the levels were associated with protection from SARS-CoV-2 infection, and (iii) to assess whether the association was different in the pre-Omicron compared with the Omicron period. The QuantiVac Euroimmun ELISA test was used to quantify anti-S1 IgG levels. The entire study period (16 months), the 11-month pre-Omicron period and the cross-sectional analysis before the Omicron surge included 3219, 2310, and 895 reactive serum samples from 949, 919, and 895 individuals, respectively. Mixed-effect linear, mixed-effect time-to-event, and logistic regression models were used to achieve the objectives. Age and time since infection or vaccination were the only factors associated with a decline of anti-S1 IgG levels. Higher antibody levels were significantly associated with protection from SARS-CoV-2 infection (0.89, 95% confidence interval [CI] 0.82-0.97), and the association was higher during the time period when Omicron was predominantly circulating compared with the ones when Alpha and Delta variants were predominant (adjusted hazard ratio for interaction 0.66, 95% CI 0.53-0.84). In a prediction model, it was estimated that >8000 BAU/mL anti-S1 IgG was required to reduce the risk of infection with Omicron variants by approximately 20%-30% for 90 days. Though, such high levels were only found in 1.9% of the samples before the Omicron surge, and they were not durable for 3 months. Anti-S1 IgG antibody levels are statistically associated with protection from SARS-CoV-2 infection. However, the prediction impact of the antibody level findings on infection protection is limited.

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Seroprevalence of SARS-CoV-2 infection among frontline police personnel in Mumbai, India

et al. 2022

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Introduction A serosurvey was designed to ascertain the extent of infection among police personnel in Mumbai, India, during the last week of January 2021, at the end of the first wave of the COVID-19 pandemic, and just before the introduction of vaccination. Methods The survey was carried out to screen for SARS-CoV-2 among 3232 police personnel. Of the 3176 participants willing for blood sample collection, 3077 personnel were found to be eligible for testing antibodies against the SARS-CoV-2 virus using the Roche Diagnostics’ Elecsys Anti-SARS-CoV-2 assay. Results The overall seroprevalence was 74.1% (95% CI 72.5–75.6). Males (75.1%, 73.4–76.8) had significantly higher seroprevalence than females (69.8%, 66.0-73.3), 18–39 years age group (76.4%, 74.4–78.3) than 40–59 years age group (70.6%, 67.9–73.1), non-officers (75.2%, 73.5–76.7) than officers (63.8%, 58.2–69.0), and personnel without comorbidities (75.0%, 73.3–76.6) than with comorbidities (69.7%, 65.6–73.5). Additionally, personnel with resident members positive for COVID-19 (89.6%, 84.7–93.1), personnel having reported COVID-19 earlier (95.5%, 93.8–96.7), and personnel having PCR positivity earlier (96.4%, 94.7–97.6) had significantly higher seroprevalences than others. All other variables, including diabetes and blood glucose status, lipid levels and thyroid enzymes, were not significantly associated with the seroprevalence levels. Conclusions Almost three-fourths of frontline police personnel had evidence of past COVID-19 infection at the end of the first wave in January 2021, just before the introduction of COVID-19 vaccination. These frontline non-healthcare essential workers are an important risk group, and amenable to rapid serosurveys. These findings may help in estimating transmission status in the general community, along with disease burden, aiding prioritization of healthcare services.

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A Multidimensional Cross-Sectional Analysis of Coronavirus Disease 2019 Seroprevalence Among a Police Officer Cohort: The PoliCOV-19 Study

Cited by 4 publications

References 27 publications

Serosurveillance after a COVID‐19 vaccine campaign in a Swiss police cohort

Serosurveillance after a COVID‐19 vaccine campaign in a Swiss police cohort

Do quantitative levels of antispike‐IgG antibodies aid in predicting protection from SARS‐CoV‐2 infection? Results from a longitudinal study in a police cohort

Seroprevalence of SARS-CoV-2 infection among frontline police personnel in Mumbai, India

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