2022
DOI: 10.3389/fchem.2022.874965
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A Multicomponent Polymer-Metal-Enzyme System as Electrochemical Biosensor for H2O2 Detection

Abstract: Herein, an Au nanoparticles-polydopamine-poly acrylic acid-graphene (Au NPs-PDA-PAA-graphene) multicomponent nanohybrid is fabricated by surface functionalization of graphene alongside extensive in-situ growth of Au nanoparticles. The as-obtained nanocomposite possesses good hydrophilicity, excellent biocompatibility and high biomolecules loading capacity, which acts as an ideal platform for enzyme modification. Considering this fact, Horseradish peroxidase is expressively immobilized upon Au NPs-PDA-PAA-graph… Show more

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Cited by 7 publications
(5 citation statements)
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“…In order to ensure an optimized electron transfer, these proteins are often immobilized on highly conductive materials, both organic and inorganic, with a large surface area [248]. Interesting examples of these materials that also find application in the bio-medical sector are gold nanoparticles [249][250][251], nanometric metal oxides [252,253], metal nanoparticle-MOF [254][255][256][257], carbon nanotube-MOF [258] and metal nanoparticle-polymers [259,260].…”
Section: Detection Methods For H 2 Omentioning
confidence: 99%
“…In order to ensure an optimized electron transfer, these proteins are often immobilized on highly conductive materials, both organic and inorganic, with a large surface area [248]. Interesting examples of these materials that also find application in the bio-medical sector are gold nanoparticles [249][250][251], nanometric metal oxides [252,253], metal nanoparticle-MOF [254][255][256][257], carbon nanotube-MOF [258] and metal nanoparticle-polymers [259,260].…”
Section: Detection Methods For H 2 Omentioning
confidence: 99%
“…This multicomponent hybrid composite biosensor exhibits high sensitivity towards the determination of H 2 O 2 with detection limit going down to 0.02 μm. 217 Another point of intensive focus in recent researches, is the more rely on green technology in production of 2D GDsbased composites. For example: an interesting study, published in the last year (2022), demonstrates the design of GO/Ag NPs composite by ex-situ green chemistry approach.…”
Section: Development Perspectives and Future Outlookmentioning
confidence: 99%
“…This multicomponent hybrid composite biosensor exhibits high sensitivity towards the determination of H 2 O 2 with detection limit going down to 0.02 μm. 217…”
Section: Development Perspectives and Future Outlookmentioning
confidence: 99%
“…Noble metals like gold (Au) [ 64 ] and platinum (Pt) [ 65 ], along with metal nanoparticles like silver (Ag) [ 66 ], palladium (Pd) [ 67 ], and copper (Cu) [ 68 ], are also employed. Polymer nanocomposites incorporating nanoparticles or nanotubes contribute to material diversity [ 69 ]. However, Co 3 O 4 emerges as an advantageous choice due to its exceptional catalytic activity, ensuring enhanced electrochemical reactions critical for H 2 O 2 detection.…”
Section: Introductionmentioning
confidence: 99%