A Multicolor Nanoprobe for Detection and Imaging of Tumor‐Related mRNAs in Living Cells

Li, Na; Chang, Chen; Pan, Wei; Tang, Bo

doi:10.1002/anie.201203767

Cited by 307 publications

(258 citation statements)

References 42 publications

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“…4, even with concentrations as high as 1.0 Â 10 À 11 M of actin mRNA, let7a, let-7e and let-7f, signals were not more than 10% relative to those toward the case of target survivin mRNA. This high specificity is much better than those of previously reported mRNA biosensors (Li et al, 2012), due to the mismatch discrimination ability of the DSN (Table S2).…”

Section: Selectivity Of the Sensing Strategymentioning

confidence: 59%

A dual-amplified electrochemical detection of mRNA based on duplex-specific nuclease and bio-bar-code conjugates

Wang

Luo

et al. 2015

Biosensors and Bioelectronics

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Section: Selectivity Of the Sensing Strategymentioning

confidence: 59%

A dual-amplified electrochemical detection of mRNA based on duplex-specific nuclease and bio-bar-code conjugates

Wang

Luo

et al. 2015

Biosensors and Bioelectronics

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“…Hybridization tests were carried out in solutions spiked with a mixture of three targets, and the nanoscale MBs respond only to the specific target with negligible crosstalk. Since DNAAuNP conjugates show highly efficient cellular uptake, later Li et al [105] demonstrated a multicolor fluorescence nanoprobe based on nanoflares, that can simultaneously detect and image three intracellular tumor-related mRNAs in living cells. The fluorescence intensity was found to correlate well with the concentration of tumor-related mRNA in living cells, which provides a useful means to monitor the stage of tumor progression.…”

Section: Engineering Of Nano-surfaces With Dna Nanostructuresmentioning

confidence: 99%

Bio-surface engineering with DNA scaffolds for theranostic applications

et al. 2018

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Biosensor design is important to bioanalysis yet challenged by the restricted target accessibility at the biomolecule-surface (bio-surface). The last two decades have witnessed the appearance of various "art-like" DNA nanostructures in one, two, or three dimensions, and DNA nanostructures have attracted tremendous attention for applications in diagnosis and therapy due to their unique properties (e.g., mechanical flexibility, programmable control over their shape and size, easy and high-yield preparation, precise spatial addressability and biocompatibility). DNA nanotechnology is capable of providing an effective approach to control the surface functionality, thereby increasing the molecular recognition ability at the biosurface. Herein, we present a critical review of recent progress in the development of DNA nanostructures in one, two and three dimensions and highlight their biological applications including diagnostics and therapeutics. We hope that this review provides a guideline for bio-surface engineering with DNA nanostructures.

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“…Among these, the gold-based nanoparticles are highly preferable for bioimaging and therapeutic applications due to their remarkable optical properties, high photothermal conversion efficiency, and easy surface functionalization (Govorov and Richardson 2007;Li et al 2012;Zhang et al 2014). It is worth noting that the localized surface plasmon resonance (LSPR) properties of gold nanoparticles depend heavily on their shape, size, and structures (Jones et al 2011;Nehl and Hafner 2008).…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of gold nanostars using plant polyphenols for cancer photoacoustic imaging and photothermal therapy

et al. 2016

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Branched plasmonic nanostructures have been found to exhibit strong enhancement of the electromagnetic field surrounding their multibranched petals. This feature endows them with improved performance in catalysis, surface-enhanced Raman scattering, photoacoustic imaging, and photothermal therapy. Albeit several synthesis techniques have been developed, the precisely controlled growth of highly branched nanostructures with a one-pot surfactant-free procedure is still challenging. Herein, we present a simple seedless route to synthesize gold nanostars (AuNSs) using a natural plant polyphenol, gallic acid (GA), as a reducing and stabilizing agent. The size and shape of AuNSs can be tuned by simply adjusting the amount of added GA. Under the optimum condition, the as-prepared AuNSs with diameters about 100 nm exhibit strong near-infrared absorption, good photothermal efficiency, and high biocompatibility. We demonstrate that AuNSs can be utilized for simultaneous photoacoustic imaging and photothermal therapy in living cancer cells. This study highlights facile synthesized AuNSs could serve as a promising platform for cancer diagnosis and therapy.

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A Multicolor Nanoprobe for Detection and Imaging of Tumor‐Related mRNAs in Living Cells

Cited by 307 publications

References 42 publications

A dual-amplified electrochemical detection of mRNA based on duplex-specific nuclease and bio-bar-code conjugates

A dual-amplified electrochemical detection of mRNA based on duplex-specific nuclease and bio-bar-code conjugates

Bio-surface engineering with DNA scaffolds for theranostic applications

One-pot synthesis of gold nanostars using plant polyphenols for cancer photoacoustic imaging and photothermal therapy

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