A multicentric individually-tailored controlled trial of education and professional support to nursing home staff: Research protocol and baseline data of the IQUARE study

Barreto, Philipe de Souto; Lapeyre‐Mestre, Maryse; Mathieu, Céline; Piau, Christine; Bouget, Catherine; Cayla, Françoise; Vellas, Bruno; Rolland, Yves

doi:10.1007/s12603-013-0008-9

Cited by 51 publications

(29 citation statements)

References 18 publications

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“…The study comprised a 6‐month intervention period and an 18‐month follow‐up, and it was designed to improve NH quality indicators related to frequent medical problems faced by NH staff. The full protocol and final results have been described elsewhere . IQUARE followed the principles of the Declaration of Helsinki and complied with ethical standards in France; study protocol was approved by the ethics committee of the Toulouse University Hospital and the Consultative Committee for the Treatment of Research Information on Health (commission nationale de l'informatique et des libertés [CNIL]: 07‐438).…”

Section: Methodsmentioning

confidence: 99%

Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study

Girard

Sourdet

Cantet

et al. 2019

J American Geriatrics Society

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BACKGROUND Acetaminophen is the most widely used analgesic today. A recent systematic review found increased adverse events and mortality at therapeutic dosage. Our aim was to challenge these results in a large sample of older adults living in nursing homes (NHs). DESIGN Prospective study using data from the Impact of Educational and Professional Supportive Interventions on Nursing Home Quality Indicators project (IQUARE), a multicenter, individually tailored, nonrandomized controlled trial in NHs across southwestern France. SETTING/PARTICIPANTS We studied data from 5429 participants living in 175 NHs (average age, 86.1 ± 8.1 years; 73.9% women). MEASUREMENTS All prescriptions obtained at baseline were analyzed by a pharmacist for acetaminophen use as stand‐alone or associated. Myocardial infarction (MI) and strokes were reported from participants' medical records at 18‐month follow‐up. Dates of death were obtained. Data collection was done through an online questionnaire at baseline and at 18 months by NH staff. Analyses were realized in our total population and a population matched on propensity score of acetaminophen intake. Six models were run for each outcome. RESULTS A total of 2239 participants were taking, on average, 2352 ± 993 mg of acetaminophen daily. Results for mortality were: hazard ratio (HR) = 0.97 (95% confidence interval [CI] = 0.86‐1.10). No associations between acetaminophen intake and the risk of mortality or MI were found. In one of our models, acetaminophen intake was associated with a significant increased risk of stroke in diabetic subjects (OR = 3.19; 95% CI = 1.25‐8.18; P = .0157). [Correction added March 16, 2019, after first publication online. In the previous sentence, “HR” was mistakenly used instead of “OR”.] CONCLUSION Despite old age, polypharmacy, and polymorbidity, acetaminophen was found safe for most, but not all, of our NH study population. Pain management in NHs is a health priority, and acetaminophen remains a good therapeutic choice as a first‐line analgesic. More studies are needed on older diabetic patients.

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Section: Methodsmentioning

confidence: 99%

Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study

Girard

Sourdet

Cantet

et al. 2019

J American Geriatrics Society

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“…IQUARE's research protocol has been fully described elsewhere [11]; it will be briefly reported hereafter. IQUARE's research protocol has been fully described elsewhere [11]; it will be briefly reported hereafter.…”

Section: Methodsmentioning

confidence: 99%

“…Nursing home residents are characterized by an overall state of health vulnerability [10], which can be illustrated by the presence of multi-morbidity [11] and polypharmacy [12].…”

Section: Introductionmentioning

confidence: 99%

Drug treatment for diabetes in nursing home residents

et al. 2013

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“…The main objective of IQUARE was to test the impact of a quality improvement approach on nursing home quality indicators (e.g., evaluation of pain, evaluation of depression, etc). The protocol of IQUARE has been published elsewhere [25]. In brief, IQUARE involved 175 NH, and 6275 NH residents.…”

Section: Participantsmentioning

confidence: 99%

Indicators of oral nutritional supplements prescription in nursing home residents: A cross-sectional study

et al. 2016

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A multicentric individually-tailored controlled trial of education and professional support to nursing home staff: Research protocol and baseline data of the IQUARE study

Abstract: IQUARE is one of the largest controlled trials in NHs developed in France. Results from IQUARE may constitute the basis for the development of new work modalities within the French health system, and serve as a model of a feasible research approach in NHs.

Cited by 51 publications

References 18 publications

Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study

Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study

Drug treatment for diabetes in nursing home residents

Indicators of oral nutritional supplements prescription in nursing home residents: A cross-sectional study

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