A Multicentre Trial to Evaluate Three Treatments for Recurrent Idiopathic Calcium Stone Disease — A Preliminary Report

Robertson, William; Peacock, Munro; Selby, P. L.; Williams, R. E.; Clark, Phil; Chisholm, Geo. G.; Hargreaves, T. B.; Rose, M; Wilkinson, Helen C.

doi:10.1007/978-1-4684-7272-1_115

Cited by 29 publications

(17 citation statements)

References 3 publications

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“…Reg ular control in the course of therapy is necessary in order to recognize changes in calcium excretion early and to influence this in time. A British multicentre study showed practically no prophylactic action of allopurinol on recurrence [33], and thus indirectly confirmed our indications, taking into account their typical patient col lective [31].…”

Section: Uric Acidsupporting

confidence: 56%

Clinical Aspects of Stone Formation and Conservative Treatment

Ulshöfer

1986

Urol Int

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Clinical aspects of stone formation and conservative treatment need to consider the following factors: (1) Epidemiological studies and their knowledge are necessary as they have permitted important conclusions with the regard to risk and history of urolithiasis. (2) Laboratory diagnosis is a prerequisite to therapy. Mode and extent of laboratory investigations depend whether or not proven measures can result. The distinction between practice and research and their demands must clearly be made. (3) Risk-orientated laboratory parameters must be assessed from a point of view which concentrates on the possibility of therapeutic influence. Looking for and finding abnormal values is more likely to satisfy the statistician than the clinician. (4) The choice of treatment depends not only on laboratory values but also on the individual characteristics of the patient such as sex, age, occupation and education as well as general state of health and its impairment by stone recurrence. (5) Classic (diuresis and diet) as well as drug therapy need clear indications, where risk and benefit must be balanced individually. Therapy needs to be controlled on the one hand in order to make indications safer through increasing experience, and on the other hand to make indications preciser by the analysis of failures.

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Section: Uric Acidsupporting

confidence: 56%

Clinical Aspects of Stone Formation and Conservative Treatment

Ulshöfer

1986

Urol Int

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“…Stone specific diagnostic and therapeutic algorithms Figure 2 [31][32][33][34][35][36][37][38][39][40][41][42][43][44]. Elevated levels of ionized calcium in serum (or total calcium and albumin) require assessment of intact PTH to confirm or exclude suspected hyperparathyroidism (HPT) [60].…”

Section: 3mentioning

confidence: 99%

“…If urine pH remains constantly >6.2, urinary acidification with L-methionine may be helpful(Fig. 3, Table 8).For infection-associated calcium phosphate stones, it is important to consider the guidance given for infection stones[31][32][33][34][35][36][37][38]. 3.3.1.3.…”

mentioning

confidence: 97%

Metabolic Evaluation and Recurrence Prevention for Urinary Stone Patients: EAU Guidelines

Skolarikos¹,

Straub²,

Knoll³

et al. 2015

European Urology

288

199

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“…A recent preliminary report evaluated three different treatment modalities for recurrent idiopathic calcium stone disease by their effect on the risk factor (PSF) for stone formation [14]. During treatment the Psf values were only slightly reduced in the group treated with allo purinol, whereas thiazides and orthophosphates had a significant effect.…”

Section: Partmentioning

confidence: 99%

“…The observation that the removal of excess uric acid from patients' urines does not improve different risk fac tors for CaOx stone formation [6,14] indicates that the mere presence of uric acid may not be the triggering mechanism for CaOx stone formation.…”

mentioning

confidence: 99%