A multicentre surveillance study on the characteristics, bacterial aetiologies and <i>in vitro</i> antibiotic susceptibilities in patients with acute exacerbations of chronic bronchitis

Hui, David S.; Ip, Margaret; Ling, T. K. W.; Chang, Shan-Chwen; Liao, Chun-Hsing; Yoo, Chul Gyu; Kim, Deog Kyeom; Yoon, Ho Il; Udompanich, Visit; Mogmeud, Somkid; Muttalif, Razak; Salleh, Azmi M.; Roa, Camilo; Mendoza, Myrna; Fajardo-Ang, Concepcion; Soepandi, Priyanti Zuswayudha; Isbaniah, Fathiyah; Burhan, Erlina; Sudarmono, Pratiwi; Mangunnegoro, Hadiarto; Liu, Hans H.

doi:10.1111/j.1440-1843.2011.01943.x

Cited by 29 publications

(21 citation statements)

References 36 publications

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“…In this study, K. pneumoniae was a common bacterial pathogen. This is similar to a previous Asian multicenter study which included Thailand 21. Our study included COPD with severe airflow limitation, which may increase lower airway bacterial colonization 22.…”

Section: Discussionsupporting

confidence: 80%

Serum inflammatory biomarkers and clinical outcomes of COPD exacerbation caused by different pathogens

Kawamatawong¹,

Apiwattanaporn²,

Siricharoonwong³

2017

COPD

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Background and objectiveCOPD exacerbation is characterized by worsening of symptoms, warranting change in treatment. Systemic and airway inflammation play roles in the pathogenesis of COPD exacerbation. We hypothesized whether increased serum inflammatory biomarkers are associated with the clinical outcomes of COPD exacerbation caused by different infectious pathogens.MethodsCOPD patients with exacerbation were recruited from a hospital emergency department during 2014–2015. Serum procalcitonin (PCT) and C-reactive protein (CRP) were measured. Dyspnea, eosinopenia, consolidation, acidemia, and atrial fibrillation (DECAF) score was calculated for predicting mortality. Multiplex polymerase chain reaction was carried out for respiratory viral assay from nasopharyngeal swabs, and sputum bacterial culture was also performed. Hospital mortality, invasive mechanical ventilation requirement, and length of hospital stay (LOS) were evaluated, and their associations with clinical characteristics, DECAF score, and serum biomarkers were examined.ResultsA total of 62 COPD patients were enrolled. These patients were classified as Global Initiative for Obstructive Lung Disease (GOLD) stage 2, 3, and 4 in 12.9%, 6.4%, and 80.7% of cases, respectively. Isolated bacterial exacerbation was recovered in 30.6% of exacerbation episodes: Klebsiella pneumoniae was the most commonly identified bacteria. Viral pathogens and coinfections were noted in 9.6% and 16.1% of exacerbated patients, respectively. Influenza was the most commonly detected viral pathogen. Serum biomarkers and DECAF score for viruses, bacteria, coinfection, and noninfectious causes of exacerbations were similar. Neither DECAF score nor serum biomarkers were able to differentiate patients with and without mortality or requiring mechanical ventilation. Increased serum PCT was noted in patients with LOS ≥7 days when compared with those with LOS <7 days (0.38 ng/mL vs 0.1 ng/mL; P=0.035).ConclusionIncreased serum PCT is associated with longer LOS in COPD exacerbation. However, CRP and DECAF score play limited roles in predicting clinical outcome and lack an association with causes of exacerbation.

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Section: Discussionsupporting

confidence: 80%

Serum inflammatory biomarkers and clinical outcomes of COPD exacerbation caused by different pathogens

Kawamatawong¹,

Apiwattanaporn²,

Siricharoonwong³

2017

COPD

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show abstract

“…This finding is similar to that of Narayanagowda et al 20 , Hui et al 22 and Lin et al 23 who found K. pneumoniae as the predominant organism in their study. However, they also found other gram-negative organisms like P. aeruginosa and Acinetobacter spp.…”

Section: Discussionsupporting

confidence: 82%

Pattern of Sputum Bacteriology in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Rashid¹,

Ahmed²

2018

J Enam Med Col

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“…in this study (except ampicillin and nitrofurantoin), a finding that is similar to others. 20,23 In contrast, P. aeruginosa was only >50% susceptible to cefoperazone and amikacin. Notably, the susceptibility of P. aeruginosa to imipenem was 23.8%, which is significantly lower than reported values of 74.8% in 2003 and 70.5% in 2008, in China.…”

Section: Discussionmentioning

confidence: 99%

Multicentre investigation of pathogenic bacteria and antibiotic resistance genes in Chinese patients with acute exacerbation of chronic obstructive pulmonary disease

Cui

Wang

et al. 2015

J Int Med Res

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Objective: A prospective observational study to investigate the distribution and antimicrobial resistance of pathogenic bacteria in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in Beijing, China. Methods: Patients with AECOPD were recruited from 11 general hospitals. Sputum specimens were cultured and bacteria identified. Antibiotic susceptibility was determined for each isolate, and presence of antibiotic resistance genes was evaluated using polymerase chain reaction.

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A multicentre surveillance study on the characteristics, bacterial aetiologies and in vitro antibiotic susceptibilities in patients with acute exacerbations of chronic bronchitis

Cited by 29 publications

References 36 publications

Serum inflammatory biomarkers and clinical outcomes of COPD exacerbation caused by different pathogens

Serum inflammatory biomarkers and clinical outcomes of COPD exacerbation caused by different pathogens

Pattern of Sputum Bacteriology in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Multicentre investigation of pathogenic bacteria and antibiotic resistance genes in Chinese patients with acute exacerbation of chronic obstructive pulmonary disease

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