A multicentre study evaluating the risk and prevalence of diabetic retinopathy in children and young people with type 1 diabetes mellitus

Ng, Sze May; Ayoola, Oluwagbemiga Oluwole; McGuigan, Michael; Chandrasekaran, S.

doi:10.1016/j.dsx.2018.11.063

Cited by 17 publications

(23 citation statements)

References 18 publications

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“…The growth of DR is impacted by environmental elements that may happen under the background of a given kind of diabetes mellitus. Furthermore, DR most commonly develops early in susceptible patients with T1DM [33]. After multivariable analysis, we did not observe that rs2910164 was a risk factor that was signi cantly associated with DR. Further researches with a larger cohort size are warranted to dig these given phenotypes more accurately in relation to miR-146a SNPs.…”

Section: Discussioncontrasting

confidence: 63%

Association of four gene polymorphisms in Chinese Guangxi population with diabetic retinopathy in type 2 diabetic patients

Jiang

Ding

Xiong

et al. 2021

Preprint

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Background: Diabetic retinopathy (DR) is one of the most common chronic microvascular complications of diabetes. Many studies have suggested that genetic factors are important in the context of DR. This study evaluated the associations of GWAS-identiﬁed DR-associated SNPs in a Chinese population in Guangxi Province with type 2 diabetes mellitus (T2DM).Methods: A total of 386 hospitalized T2DM patients without proliferative diabetic retinopathy (PDR) and 316 hospitalized T2DM patients with PDR were included in this case–control study. Four tag SNPs, rs1800896 in the IL-10 gene, rs2010963 in the VEGFA gene, rs2070600 in the RAGE gene and rs2910164 in the miR-146a gene, were examined using KASP (Kompetitive Allele Specific PCR) Genotyping Assays.Results: There were no signiﬁcant differences in the genotype or allele frequencies of the miR-146a polymorphism (rs2910164) between subjects with DR and without DR. For rs1800896, the TT allele was determined to be associated with a decreased risk of PDR (P adjusted = 0.022). For rs2010963, 2 alleles (CC and GG) were associated with an increased risk of PDR (P adjusted-CC = 0.048, P adjusted-GG = 0.028). For rs2070600, 2 alleles (TT and CT) were associated with a decreased risk of PDR (P adjusted TT = 0.033, P adjusted CT = 0.002).Conclusions: The polymorphisms rs1800896 in the IL-10 gene, rs2010963 in the VEGFA gene and rs2070600 in the RAGE gene are associated with the risk of PDR in the Han Chinese population of Guangxi Province. Our ﬁndings provide suggestive evidence that these polymorphisms may be involved in the pathogenesis of PDR and should be investigated further.

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Section: Discussioncontrasting

confidence: 63%

Association of four gene polymorphisms in Chinese Guangxi population with diabetic retinopathy in type 2 diabetic patients

Jiang

Ding

Xiong

et al. 2021

Preprint

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“…Hyperglycaemia has long been associated with an increased risk of developing DR as seen in the landmark DCCT study as well as many other studies in the UK [33,34], Europe [35,36] and the US [37,38]. The age standardised prevalence of DR in the global meta-analysis increased with increasing HbA 1c from 17.9% at ≤ 53mmol/mol to 51.2% at HbA 1c >75mmol/mol [8].…”

Section: Risk Factors For Drmentioning

confidence: 89%

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Thomas¹,

Ng²

2020

Journal of Diabetes and Clinical Research

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Prevalence of DR is variable as reported in several studies. This variability is due to differences in study populations such as age, type of diabetes, and location i.e. community or hospital setting, methods of detecting diabetic retinopathy fundoscopy, digital photography and slit lamp examination and grading protocols used. The global prevalence of DR was 34.6% from a pooled analysis of 22,896 individuals with diabetes [8], this was updated in the International Diabetes Federation (IDF) atlas 9 th edition with any DR reported to be 27.0%, nonproliferative DR 25.2%, proliferative DR 1. 4% and DME 4.6% between 2015 and 2019 [9]. The lowest prevalence of any DR was reported in South East Asia at 12.5% and highest in the Western Pacific at 36.3%. The prevalence of DR in children and young people with diabetes has been

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“…We also found that those participants with at least one barrier to DR screening had a higher median age and duration of disease, a concerning finding as these are risk factors for the development of DR 1,13,14 . As a particularly vulnerable population, 15,16 we hypothesized that young adults would be more likely to report barriers.…”

Section: Discussionmentioning

confidence: 85%

Barriers to retinopathy screening in youth and young adults with type 1 diabetes

et al. 2020

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Early detection of diabetic retinopathy (DR) is imperative; however, adherence to screening guidelines is poor. We hypothesized that youth and young adults with type 1 diabetes (T1D) who met American Diabetes Association criteria for recommended DR screening at the time of the study (10 years old or greater with diabetes duration of 5 years or more) would report multiple barriers to screening and that targeted barriers and subpopulations could be identified to improve access to care. 271 youth aged 10 to 26 years with T1D of at least 5 years duration were recruited from clinic, diabetes camp, and a diabetes conference and completed a patient‐reported questionnaire. 113 (41.7%) reported at least one barrier to DR screening, with missed school and work being the most common (20.7%). Older participants (P = 0.007) and those with a longer diabetes duration (P = 0.018) were more likely to report barriers to screening. Recruitment location, sex, race and ethnicity, HbA1c, insulin regimen, and clinic visit frequency were not associated with reporting at least one barrier. Slightly less than two‐thirds (62.1%) of participants who responded (n = 235 out of 271) adhered to recommended screening guidelines of the time and reported having an eye exam within the past year, 24.7% 12–23 months ago, 9.8% 2 years ago or more, and 3.4% had never had a DR exam. As older patients and those with longer duration of diabetes are more likely to have DR, targeted interventions to address barriers to care, such as, missed school and work should be implemented in these groups.

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A multicentre study evaluating the risk and prevalence of diabetic retinopathy in children and young people with type 1 diabetes mellitus

Cited by 17 publications

References 18 publications

Association of four gene polymorphisms in Chinese Guangxi population with diabetic retinopathy in type 2 diabetic patients

Association of four gene polymorphisms in Chinese Guangxi population with diabetic retinopathy in type 2 diabetic patients

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Barriers to retinopathy screening in youth and young adults with type 1 diabetes

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