A multicentre open clinical trial to assess the tolerability and efficacy of Sage tablets in menopausal patients with hot flushes

Bommer, S; Klein, Pavel; Suter, Andy

doi:10.1055/s-0029-1234964

Cited by 3 publications

(3 citation statements)

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“…The efficacy of sage for the treatment of hot flushes during menopause was proven by a multicentre open clinical trial (Bommer et al, 2009). A statistically significant effect of symptomatic relief in patients with acute pharyngitis was detected (Hubbert et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…The European Medicines Agency (EMA) reported a number of unpublished studies confirming the perspiration–inhibiting and antihidrotic effects of sage (European Medicines Agency, 2009 ). The efficacy of sage for the treatment of hot flushes during menopause was proven by a multicentre open clinical trial (Bommer et al, 2009 ). A statistically significant effect of symptomatic relief in patients with acute pharyngitis was detected (Hubbert et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea)

Walch¹,

Tinzoh

Zimmermann

et al. 2011

Front. Pharmacol.

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Sage (Salvia officinalis L.) is used as an herbal medicinal product, with the most typical form of application as infusion with boiling water (sage tea). The well-established traditional uses include symptomatic treatment of mild dyspeptic complaints, the treatment of inflammations in the mouth and the throat, and relief of excessive sweating and relief of minor skin inflammations. In this study, sage teas prepared from commercially available products were chemically analyzed for polyphenolic content using liquid chromatography, for antioxidant potential using the oxygen radical absorbance capacity method, and for the Folin–Ciocalteu (FC) index. The sage teas showed a high variation for all parameters studied (up to 20-fold differences for rosmarinic acid). Univariate and multivariate analyses showed that the antioxidant potential, which varied between 0.4 and 1.8 mmol trolox equivalents/100 mL, was highly dependent on rosmarinic acid and its derivatives. The FC index also showed a high correlation to these polyphenols, and could therefore be used as a screening parameter for sage tea quality. The considerable differences in polyphenolic composition and antioxidant capacity between the brands lead to a demand for quality standardization, especially if these sage teas are to be used for therapeutic purposes. Further research also appears to be necessary to characterize the dose–benefit relationship, as sage may also contain a constituent (thujone) with potentially adverse effects.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea)

Walch¹,

Tinzoh

Zimmermann

et al. 2011

Front. Pharmacol.

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show abstract

“…It is reported to have anti-inflammatory, antibacterial, and anti-fungal properties (Ghorbani and Esmaeilizadeh, 2017). It is also known for lipid profiling and antioxidant properties responsible for hypoglycaemic effects (Bommer et al, 2009;Schapowal et al, 2009). The aim of this study was to determine and compare the anti-hyperglycaemic efficacy of methanolic, hexane, ethyl acetate, and aqueous extracts of S. officinalis in alloxaninduced diabetic mice.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycaemic effects of Salvia officinalis extracts on alloxan-induced diabetic Swiss albino mice

Mbiti¹,

Mwendia²,

Mutai³

et al. 2020

J. Med. Plants Res.

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Diabetes mellitus is the fourth killer disease globally. The available management strategies are quite expensive and sometimes unsafe. This necessitates the need for bio-active drugs from medicinal plants. Although Salvia officinalis (sage) is used in herbal medicine, the scientific validation for antidiabetic effects of various extracts has been elusive. The present study aimed to determine and compare the anti-hyperglycaemic efficacy of methanolic, hexane, ethyl acetate, and aqueous leaf extracts of Salvia officinalis in alloxan-induced diabetic mice. Phytochemical screening of the extracts revealed presence of flavanone, sterols, saponins, tannins, alkaloids, and triterpenes. The extracts were subjected to preliminary in vivo bio-assays at dosage levels of 400 mg/kg for 7 days through oral administration. The aqueous extract demonstrated significant hypoglycaemic effect, p˂0.05 hence subjected to further hypoglycaemic studies for 15 days. There was a significant decrease in blood sugar levels of groups treated with aqueous extract at 400 mg/kg and 600 mg/kg doses from 452.00 ± 11.13 mg/dL and 431.00 ± 10.65 mg/dL to 256.33 ± 5.12 mg/dL and 256.67 ± 8.74 mg/dL. Weight gain improved significantly from 28.05 ± 0.39 g and 27.38 ± 0.52 g to 29.32 ± 0.42 g and 28.55 ± 0.38 g respectively compared to controls, p˂0.05. Histopathological studies revealed no significant changes in liver and kidney tissues. Besides, no significant cytotoxic effect was reported. Results from this study indicate that aqueous extract of Salvia officinalis is a potential anti-hyperglycaemic and can be used in modulating blood glucose levels.

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Sage

Charles¹

2012

Antioxidant Properties of Spices, Herbs and Other Sources

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A multicentre open clinical trial to assess the tolerability and efficacy of Sage tablets in menopausal patients with hot flushes

Cited by 3 publications

References 0 publications

Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea)

Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea)

Hypoglycaemic effects of Salvia officinalis extracts on alloxan-induced diabetic Swiss albino mice

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