A Multicentre Italian Validation Study in Aging Adults with Down Syndrome and Other Forms of Intellectual Disabilities: Dementia Screening Questionnaire for Individuals with Intellectual Disabilities

Gomiero, Tiziano; Bertelli, Marco O.; Deb, Shoumitro; Weger, Elisabeth; Marangoni, Annachiara; Bastiani, Elisa De; Mantesso, Ulrico; Vreese, Luc Pieter De

doi:10.2174/1567205014666170117094757

Cited by 19 publications

(15 citation statements)

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“…[47] reported the sensitivity of the DLD as 0.65 and specificity 0.93. The instrument was found to be a good marker of the cognitive and affective symptoms observed in the early signs of dementia [65], and displays good inter-test validity with other instruments like the SIB [53] and the Alzheimer's…”

Section: Cross-sectional Studies In Participants With Down Syndromementioning

confidence: 89%

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Screening of Cognitive Changes in Adults with Intellectual Disabilities: A Systematic Review

Paiva

Nolan

Thumser

et al. 2020

Preprint

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Background and Aims: Screening and assessment of cognitive changes in adults with Intellectual Disabilities, mainly Down Syndrome (DS), is crucial to offer appropriate services to their needs. We present a systematic review of the existing instruments assessing dementia, aiming to support researchers and clinicians’ best practice. Methods: Searches were carried out in the databases Web of Science; PubMed; PsycINFO in March 2019 and updated in May 2020. Studies were selected and examined if they: (1) focused on assessing age-related cognitive changes in person with ID; (2) included adults and/or older adults; (3) included scales and batteries for cognitive assessment. Results: Forty-eight cross-sectional studies and twenty-six longitudinal studies were selected representing a total sample of 5,851 participants (4,089 DS and 1,801 with other ID). In those studies, we found 38 scales, questionnaires, and inventories, and 14 batteries for assessing cognitive and behavioural changes in adults with DS and other ID. Conclusion: The most used instrument completed by an informant or carer was the Dementia Questionnaire for Learning Disabilities (DLD), and its previous versions. We discuss the strengths and limitations of the instruments and outline recommendations for future use.

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Section: Cross-sectional Studies In Participants With Down Syndromementioning

confidence: 89%

“…Cross-Sectional Studies Including Participants with DS and other IDThe DLD[38,39,40] revealed good psychometric properties in studies with participants with both DS as other ID. Eight studies used the DLD[47,61,62,63,64,65,66,67] Shultz et al (2004).…”

mentioning

confidence: 99%

Screening of Cognitive Changes in Adults with Intellectual Disabilities: A Systematic Review

Paiva

Nolan

Thumser

et al. 2020

Preprint

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“…Our study has several strengths. First, the 15 structures and organizations, managed by different stakeholders, parental associations, public health services, cooperatives or local institutions can be considered representative of the Italian scenario offering services to more than 3,000 adults and elderly with ID both in small rural areas and in medium and large urban areas, distributed over most of the national territory ([ 22 ] see Fig. 1, p. 4).…”

Section: Discussionmentioning

confidence: 99%

“…Medication data for this study was drawn from a multicenter Italian validation study of the Dementia Screening Questionnaire in Intellectual Disabilities (DSQIID) which has been described in detail elsewhere [ 21 , 22 ]. In summary, 15 organizations and structures each one with previous experience in DMR-I screening [ 23 ] enrolled 398 subjects with ID aged 40 years and over.…”

Section: Methodsmentioning

confidence: 99%

Anticholinergic burden in adult and elderly people with intellectual disabilities: Results from an Italian multicenter cross-sectional study

Vreese

Mantesso²,

Bastiani³

et al. 2018

PLoS ONE

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BackgroundAdults and older people with intellectual disabilities (ID) frequently receive anti-cholinergic drugs in chronic use, but no studies in Italy to date have investigated cumulative anticholinergic exposure and factors associated with high anticholinergic burden in this frail population.AimTo probe the cumulative exposure to anticholinergics and the demographic, social and clinical factors associated with high exposure.MethodsThe 2012 updated version of the Anticholinergic Burden Score (ACB) was calculated for a multicentre sample of 276 adult and older people over 40 years with ID and associations with factors assessed.ResultsOverall, antipsychotics, antiepileptics, anxiolytics, and antidepressants were the most frequent classes contributing to the total ACB score. People living in residential care were more likely exposed to high anticholinergic burden (an ACB score of 3+): both community housing (odds ratio [OR] 4.63, 95%CI 1.08–19.95) and nursing home facility ([OR] 9.99, 95%CI 2.32–43.04). There was also a significant association between an ACB score of 3+ and reporting mental health conditions ([OR] 25.56, 95% CI 8.08–80.89) or a neurological disease ([OR] 4.14, 95%CI 1.32–12.94). Neither demographic characteristics (age and gender) nor other clinical conditions (somatic comorbidity, levels and typology of ID) were associated with higher anticholinergic load. A high burden of anticholinergic was significantly more frequent in laxative users (22.6% ACB3+ vs. 5.1% ACB 0) (p = 0.003).ConclusionsPsychotropic drugs were the highest contributors to the anticholinergic burden in adult and old age ID, especially in those people living in institutional settings with mental health and/or neurological conditions. High anticholinergic load has shown to be associated with the use of laxatives.

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“…(2) history of symptoms of dementia from family members and/or caregivers; (3) medication status; (4) screening for dementia symptoms using the DSQIID (Deb et al, 2007), which has been shown to be a valid and reliable observer-rated questionnaire for screening for dementia among adults with DS and has also been validated by an Italian group (Gomiero et al, 2017); (5) physical and neurological examinations; (6) psychiatric assessment of symptoms of depression; (7) (Aylward et al, 1997). After completion of the diagnostic workup, a multidisciplinary staff established a consensus diagnostic classification.…”

Section: Clinical Assessmentmentioning

confidence: 99%

Associations between electroencephalography power and Alzheimer's disease in persons with Down syndrome

Musaeus

Salem

Sabers

et al. 2019

J intellect Disabil Res

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Background It is complicated to diagnose dementia in persons with Down syndrome (DS). Older studies have, however, demonstrated low‐frequency activity in electroencephalography (EEG) in persons with concurrent DS and Alzheimer's disease (DS‐AD). The aim of this study was to examine whether it was possible to identify AD‐associated changes (increased high‐frequency power and decreased low‐frequency power) in persons with DS‐AD compared with DS. Methods We included 21 persons with DS‐AD and 16 with DS without cognitive deterioration assessed by the informant‐based Dementia Screening Questionnaire in Intellectual Disability. EEG was recorded for all participants. Absolute power for each electrode and global power were calculated for all frequency bands for both eyes open and eyes closed. Results For global power in the eyes closed condition, we found an increased global slow‐frequency activity and a decreased global high‐frequency activity in DS‐AD compared with DS. In addition, we found a significant difference in the global alpha/delta ratio with the largest difference found for global alpha power in DS‐AD compared with DS. Conclusions In the current study, we found that changes known to be associated with AD could also be identified when comparing DS‐AD with DS using quantitative EEG. In general, these findings suggest that EEG might be a useful tool in diagnosing AD in persons with DS, but larger studies are needed.

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A Multicentre Italian Validation Study in Aging Adults with Down Syndrome and Other Forms of Intellectual Disabilities: Dementia Screening Questionnaire for Individuals with Intellectual Disabilities

Abstract: The present study confirms the cross-cultural value of DSQIID which was proved to be a psychometrically valid and user-friendly observer-rated scale for dementia screening in adults with both DS and non-DS ID.

Cited by 19 publications

References 0 publications

Screening of Cognitive Changes in Adults with Intellectual Disabilities: A Systematic Review

Screening of Cognitive Changes in Adults with Intellectual Disabilities: A Systematic Review

Anticholinergic burden in adult and elderly people with intellectual disabilities: Results from an Italian multicenter cross-sectional study

Associations between electroencephalography power and Alzheimer's disease in persons with Down syndrome

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