A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis

Rühwald, Morten; Domínguez, José; Latorre, Irene; Losi, Monica; Richeldi, Luca; Pasticci, Maria Bruna; Mazzolla, Rosanna; Goletti, Delia; Butera, Ornella; Bruchfeld, Judith; Gaines, Hans; Gerogianni, Irini; Tuuminen, Tamara; Ferrara, Giovanni; Eugen‐Olsen, Jesper; Ravn, Pernille

doi:10.1016/j.tube.2011.01.001

Cited by 109 publications

(95 citation statements)

References 35 publications

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“…Denmark and Italy 101 healthy students with no history of exposure to TB, or prior TB disease or treatment Similar negativity rate between IP-10 test (95%) and QFT-IT (99%) [53] Frahm et al…”

Section: Healthy Controlsmentioning

confidence: 88%

“…In two studies from a lowprevalence settings (Denmark and Italy), out of 187 nonexposed healthy controls, only 2% were found to be IP-10 test positive (specificity 98%) and 0% were QFT-IT positive (specificity 100%) and there was no indication of cross-reactivity with BCG vaccination [52,53]. The third study, performed in India, included 100 controls and reported positive results in 52% by the IP-10 test and 48% by the QFT-IT, probably reflecting the high prevalence of latent TB infection [54].…”

Section: Healthy Controlsmentioning

confidence: 99%

“…Review were combined (available for four studies only; positivity rates increased to 86-93%) [52][53][54][55].…”

Section: Healthy Controlsmentioning

confidence: 99%

“…Three studies compared IP-10 test and QFT-IT performance in healthy controls (TaBle 2) [52][53][54]. In two studies from a lowprevalence settings (Denmark and Italy), out of 187 nonexposed healthy controls, only 2% were found to be IP-10 test positive (specificity 98%) and 0% were QFT-IT positive (specificity 100%) and there was no indication of cross-reactivity with BCG vaccination [52,53].…”

Section: Healthy Controlsmentioning

confidence: 99%

“…The increased IP-10 positivity rate could represent either superior sensitivity or impaired specificity of the IP-10 test compared with the QFT-IT. It was shown that the presence of risk factors for TB infection (exposure history, prior TB and stay in a highly endemic area) increased the adjusted odds ratios for having a positive test result from both tests, with no significant difference between tests [53], and larger studies in groups with varying degrees of exposure are therefore needed to clarify this issue.…”

Section: Healthy Controlsmentioning

confidence: 99%

See 4 more Smart Citations

IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions

Rühwald

Aabye

Ravn

2012

Expert Review of Molecular Diagnostics

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119

113

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Section: Healthy Controlsmentioning

confidence: 88%

Section: Healthy Controlsmentioning

confidence: 99%

“…Review were combined (available for four studies only; positivity rates increased to 86-93%) [52][53][54][55].…”

Section: Healthy Controlsmentioning

confidence: 99%

Section: Healthy Controlsmentioning

confidence: 99%

Section: Healthy Controlsmentioning

confidence: 99%

See 3 more Smart Citations

IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions

Rühwald

Aabye

Ravn

2012

Expert Review of Molecular Diagnostics

Self Cite

119

113

View full text Add to dashboard Cite

Primary Care Screening and Treatment for Latent Tuberculosis Infection in Adults

Kahwati

Feltner

Halpern

et al. 2016

JAMA

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Screening for Latent Tuberculosis Infection in Adults

Jonas

Riley

Lee

et al. 2023

JAMA

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ImportanceLatent tuberculosis infection (LTBI) can progress to active tuberculosis disease, causing morbidity and mortality.ObjectiveTo review the evidence on benefits and harms of screening for and treatment of LTBI in adults to inform the US Preventive Services Task Force (USPSTF).Data SourcesPubMed/MEDLINE, Cochrane Library, and trial registries through December 3, 2021; references; experts; literature surveillance through January 20, 2023.Study SelectionEnglish-language studies of LTBI screening, LTBI treatment, or accuracy of the tuberculin skin test (TST) or interferon-gamma release assays (IGRAs). Studies of LTBI screening and treatment for public health surveillance or disease management were excluded.Data Extraction and SynthesisDual review of abstracts, full-text articles, and study quality; qualitative synthesis of findings; meta-analyses conducted when a sufficient number of similar studies were available.Main Outcomes and MeasuresScreening test accuracy; development of active tuberculosis disease, transmission, quality of life, mortality, and harms.ResultsA total of 113 publications were included (112 studies; N = 69 009). No studies directly evaluated the benefits and harms of screening. Pooled estimates for sensitivity of the TST were 0.80 (95% CI, 0.74-0.87) at the 5-mm induration threshold, 0.81 (95% CI, 0.76-0.87) at the 10-mm threshold, and 0.60 (95% CI, 0.46-0.74) at the 15-mm threshold. Pooled estimates for sensitivity of IGRA tests ranged from 0.81 (95% CI, 0.79-0.84) to 0.90 (95% CI, 0.87-0.92). Pooled estimates for specificity of screening tests ranged from 0.95 to 0.99. For treatment of LTBI, a large (n = 27 830), good-quality randomized clinical trial found a relative risk (RR) for progression to active tuberculosis at 5 years of 0.35 (95% CI, 0.24-0.52) for 24 weeks of isoniazid compared with placebo (number needed to treat, 112) and an increase in hepatotoxicity (RR, 4.59 [95% CI, 2.03-10.39]; number needed to harm, 279). A previously published meta-analysis reported that multiple regimens were efficacious compared with placebo or no treatment. Meta-analysis found greater risk for hepatotoxicity with isoniazid than with rifampin (pooled RR, 4.22 [95% CI, 2.21-8.06]; n = 7339).Conclusions and RelevanceNo studies directly evaluated the benefits and harms of screening for LTBI compared with no screening. TST and IGRAs were moderately sensitive and highly specific. Treatment of LTBI with recommended regimens reduced the risk of progression to active tuberculosis. Isoniazid was associated with higher rates of hepatotoxicity than placebo or rifampin.

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A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis

Cited by 109 publications

References 35 publications

IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions

IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions

Primary Care Screening and Treatment for Latent Tuberculosis Infection in Adults

Screening for Latent Tuberculosis Infection in Adults

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