A Multicenter Study of Removed Uric Acid Estimated by Ultra Violet Absorbance in the Spent Dialysate

A multicentre study of an enhanced optical method for measuring concentration of uric acid removed during dialysis

“…A good possibility to estimate UA concentrations using UV technique has shown in earlier studies [15] but if we use some signal processing tools we can essentially improve the accuracy and reliability of the results. Linear correlation coefficient r between laboratorial and calculated values of UA is slightly higher in case of the UV_D compared to the UV_A (0.95 vs. 0.94).…”

“…Ten uremic patients, three females and seven males, mean age 62.6 ± 18.6 years, were included in the study at the Department of Dialysis and Nephrology, North-Estonian Medical Centre, Estonia and 10 uremic patients, four females and six males, mean age 62.8 ± 20.9 years were included at the Department of Nephrology, University Hospital of Linköping, Sweden, using the clinical set-up of the experiments as described earlier [15]. All patients were on chronic thrice-weekly haemodialysis.…”

“…The possibility to estimate dialysis dose (urea-Kt/V) [13] and total removed urea by UV-absorbance [14] has been presented. Also it is shown that the removed UA can be reliably estimated in different dialysis centres by the UV technique [15]. The aim of this study was to compare concentration measurements of UA removed during dialysis by two algorithms based on UV-absorbance and the 1st derivate of UV absorbance using data from two different dialysis centres.…”

Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during Dialysis

“…A good way of estimating UA concentrations using the UV technique has been shown in previous studies [ 13 , 14 , 16 – 20 ], but if we use signal processing tools and absorbance information from several wavelengths, we can essentially improve the accuracy and reliability of the results.…”

“…Ways of monitoring UA, dialysate, and other biological fluids with optical tools have been shown previously by our and other groups [ 13 – 15 ]. If you use a simple signal processing tool for smoothing and calculating the first derivate of UV absorbance and/or absorbance or processed absorbance values from several wavelengths, more reliable results are achieved [ 16 – 20 ]. An effective way of estimating UA concentrations using the UV technique has been shown in previous studies by our group.…”