A Multicenter Study of Patch Test Reactions With Dental Screening Series

Kanerva, Lasse; Rantanen, Tapio; Aalto‐Korte, Kristiina; Estlander, Tuula; Hannuksela, Matti; Harvima, Rauno J.; Hasan, Taina; Horsmanheimo, Maija; Jolanki, R; Kalimo, Kirsti; Lahti, Arto; Lammintausta, Kaija; Lauerma, Antti; Niinimäki, Aila; Turjanmaa, Kristiina; Vuorela, Anna-Maija

doi:10.1097/01634989-200106000-00004

Cited by 20 publications

(30 citation statements)

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“…As previously reported (2, 25–27), goldsodiumthiosulphate, nickel sulfate, and mercury were the most common positive allergens (14.0%, 13.2%, and 9.9%, respectively). The number of patients tested positive to gold and nickel was relatively high, but for both allergens the relevance of the positive reactions was not always apparent and the sensitization most likely developed from other sources.…”

Section: Discussionsupporting

confidence: 79%

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Positive patch test reactions to allergens of the dental series and the relation to the clinical presentations

2006

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The clinical manifestations of contact allergic dermatitis to dental materials are not uniform. This study was performed to detect the frequent allergens in the dental series associated with contact dermatitis and to define the causal relationship between the different allergens and the relevant clinical presentations. Between the years 2000 and 2004, 134 patients, aged 20-80 years, were patch tested. 121 patients were included in the study. The most frequent oral manifestations were cheilitis and perioral dermatitis (25.6%), burning mouth (15.7%), lichenoid reaction (14.0%), and orofacial granulomatosis (10.7%). 18 (14.9%) patients were dental personnel, all of whom suffered from hand dermatitis. The common allergens detected included goldsodiumthiosulphate (14.0%), nickel sulfate (13.2%), mercury (9.9%), palladium chloride (7.4%), cobalt chloride (5.0%), and 2-hydroxyethyl methacrylate (5.8%). Positive reactions to metals were frequent in all the different clinical variants, and no specific association between a specific clinical presentation and a particular allergen was found. Allergy to mercury was not a significant factor contributing to the pathogenesis of oral lichenoid reactions. However, a strong association with contact allergy to mercury in dental fillings was found in 2 patients with orofacial granulomatosis.

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Section: Discussionsupporting

confidence: 79%

“…Contrary to gold and nickel, most of the reactions to mercury seemed to be relevant, and the sensitization appeared to derive from dental sources. Like previous studies (26) 2‐hydroxyethyl methacrylate seems to be the best screening substance for (meth)acrylate allergy caused by dental (meth)acrylate products.…”

Section: Discussionsupporting

confidence: 71%

Positive patch test reactions to allergens of the dental series and the relation to the clinical presentations

2006

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“…There has been no systematic study on (meth)acrylate allergy solely among the dental patient population. Most published data is from case reports or studies of wider populations, where dental patients comprise only a minority of the subjects studied (11). In this study, we have found that 2‐HEMA and bis‐GMA would screen for all our (meth)acrylate‐allergic dental patients.…”

Section: Discussionmentioning

confidence: 59%

Contact allergy to (meth)acrylates in the dental series in southern Sweden: simultaneous positive patch test reaction patterns and possible screening allergens

et al. 2006

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Contact allergy to dental allergens is a well-studied subject, more so among dental professionals than dental patients. 1632 subjects had been patch tested to either the dental patient series or dental personnel series at the department of Occupational and Environmental Dermatology, Malmö, Sweden. Positive patch tests to (meth)acrylate allergens were seen in 2.3% (30/1322) of the dental patients and 5.8% (18/310) of the dental personnel. The most common allergen for both groups was 2-hydroxyethyl methacrylate (2-HEMA), followed by ethyleneglycol dimethacrylate (EGDMA), triethyleneglycol dimethacrylate, and methyl methacrylate. 47 (29 dental patients and 18 dental personnel) out of these 48 had positive patch tests to 2-HEMA. All 30 subjects who had a positive reaction to EGDMA had a simultaneous positive reaction to 2-HEMA. One dental patient reacted only to 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy) phenyl]propane (bis-GMA). From our data, screening for (meth)acrylate contact allergy with 2-HEMA alone would have picked up 96.7% (29/30) of our (meth)acrylate-allergic dental patients and 100% (18/18) of our (meth)acrylate-allergic dental personnel. The addition of bis-GMA in dental patients would increase the pick-up rate to 100%.

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“…PT is a common test for ACD or, in this case, OCA and is considered the gold standard to identify patients with suspected hypersensitivity reactions. Kanerva et al 18 reported that the most common PT‐positive reaction for dental screening is to metals. In the United States, PT is available as a preloaded system, ready‐to‐use thin‐layer rapid‐use epicutaneous test ¶ with 28 standard allergens plus negative controls 11 .…”

Section: Discussionmentioning

confidence: 99%

Oral Contact Allergy to Suture Material Resulting in Connective Tissue Graft Failure: A Case Report

Mawardi

2014

Clin Adv Periodontics

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Introduction: Sutures are used on a daily basis for many dental surgical procedures. However, the risk of oral allergic reaction triggered by suture material cannot be excluded. This case describes possible oral allergic reaction to suture material following periodontal surgery. Case Presentation: The patient presented with gingival recession of the mandibular anterior sextant requiring root coverage procedure. The patient had a significant allergy history to multiple medications and materials. After harvesting the graft, tissue was sutured using poliglecaprone 25 sutures. The patient developed an allergic reaction to the suture material presenting as severe intraoral swelling and itching. The graft was devitalized and eventually failed. Conclusions: To the best of the author's knowledge, this is the first case of possible allergic reaction to suture material in dental surgery reported in the literature. It is important to evaluate patients for any allergy history, in addition to medical and medication history, before any dental surgery. Patients with a significant allergy history, as in this case, are at higher risk of developing allergic reaction to any of the dental materials used in periodontal surgical procedures. Awareness of allergic reactions and the necessary management and intervention are critical for patient safety.

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A Multicenter Study of Patch Test Reactions With Dental Screening Series

Cited by 20 publications

References 0 publications

Positive patch test reactions to allergens of the dental series and the relation to the clinical presentations

Positive patch test reactions to allergens of the dental series and the relation to the clinical presentations

Contact allergy to (meth)acrylates in the dental series in southern Sweden: simultaneous positive patch test reaction patterns and possible screening allergens

Oral Contact Allergy to Suture Material Resulting in Connective Tissue Graft Failure: A Case Report

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