A multicenter study of malignant oral and maxillofacial lesions in children and adolescents

Abstract

Pediatric oral and maxillofacial malignant lesions were infrequent and showed wide diversity, with a prevalence of mucoepidermoid carcinomas. Analysis of malignant lesions in children and adolescents helps pediatric dentists and oncologists to obtain a better understanding of such lesions and to reduce the time for diagnosis, with a consequent improvement of prognosis.

World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review

“…Of these, nine were located in soft tissue; leiomyosarcoma ( N = 2, location: cheek), rhabdomyosarcoma ( N = 1, location: lip), malignant fibrous histiocytoma: ( N = 1; location: cheek); non‐Hodgkin lymphoma ( N = 2, location: sulcus) and SCC ( N = 1, location: tongue) (Piloni et al, ). The other study by de Arruda et al () found 58 malignant conditions out of 9,411 histopathological records in individuals aged 0–19 years old (de Arruda et al, ). Excluding hard tissue malignancies, six were SCC (location: tongue), three were mucoepidermoid carcinoma (location: jugal mucosa), two were leiomyosarcoma (location: cheek) and one each of rhabdomyosarcoma (location: jugal mucosa) and adenocarcinoma (location: lip) (de Arruda et al, ).…”

“…The other study by de Arruda et al () found 58 malignant conditions out of 9,411 histopathological records in individuals aged 0–19 years old (de Arruda et al, ). Excluding hard tissue malignancies, six were SCC (location: tongue), three were mucoepidermoid carcinoma (location: jugal mucosa), two were leiomyosarcoma (location: cheek) and one each of rhabdomyosarcoma (location: jugal mucosa) and adenocarcinoma (location: lip) (de Arruda et al, ). The study by Creath et al () was not comparable to the above studies as this study focused exclusively on oral leukoplakia in a sample where smokeless tobacco use was high.…”

“…Other reasons included non‐oral or unclear cancer diagnosis terminology ( N = 9) or the full text was unavailable or not retrievable ( N = 3). Fourteen studies were retained, and all were based on biopsy data (Abiose, Ogunniyi, & Oyejide, ; Adebayo, Ajike, & Adekeye, ; Al‐Khateeb, Al‐Hadi Hamasha, & Almasri, ; Aregbesola, Ugboko, Akinwande, Arole, & Fagade, ; Arotiba, ; de Arruda et al, ; Budhy, Soenarto, Yaacob, & Ngeow, ; Creath, Cutter, Bradley, & Wright, ; Effiom et al, ; Iatrou, Theologie‐Lygidakis, Tzerbos, & Schoinohoriti, ; Mohtasham, Saghravanian, Goli, & Kadeh, ; Piloni, Molina, & Keszler, ; Sato, Tanaka, Sato, & Amagasa, ; Trobs, Mader, Friedrich, & Bennek, ).Stratifying by WHO geographic regions, five studies were from the African region (Abiose et al, ; Adebayo et al, ; Aregbesola et al, ; Arotiba, ; Effiom et al, ), three from the Americas (de Arruda et al, ; Creath et al, ; Piloni et al, ), two each from the Eastern Mediterranean (Al‐Khateeb et al, ; Mohtasham et al, ) European (Iatrou et al, ; Trobs et al, ) and South‐East Asia/Western Pacific regions (Budhy et al, ; Sato et al, ).…”

Advances in pediatrics in 2017: current practices and challenges in allergy, endocrinology, gastroenterology, genetics, immunology, infectious diseases, neonatology, nephrology, neurology, pulmonology from the perspective of Italian Journal of Pediatrics

“…Furthermore, OMLs in children and adolescents may be the expression of malignancy, including mucoepidermoid carcinomas (22.4%), osteosarcomas (13.8%), squamous cell carcinomas (12.1%), and Burkitt’s lymphomas (12.1%) [ 84 ]. The most commonly affected sites were the palate (19%), mandible (13.8%), and maxilla (13.8%).…”

Large-extension osteosarcoma with involvement of multiple maxillofacial structures: a rare case report

“…The tumor most commonly appears in the metaphases of the long bones of children and adolescents, and is rare in the head and neck, comprising from 6% to 10% of all osteosarcomas and less than 1% of all cancers located in this region (Nissanka et al, 2007;Laskar et al, 2008;Chen et al, 2017;Kimura et al, 2017;Krishnamurthy & Palaniappan, 2018). Despite its rarity in the oral-maxillofacial region, it is the second most common malignancy in this location in children and adolescents (de Arruda et al, 2017).…”