A Multicenter Study Involving the Use of a Human Acellular Dermal Regenerative Tissue Matrix for the Treatment of Diabetic Lower Extremity Wounds

Winters, Christopher; Brigido, Stephen A.; Liden, Brock; Simmons, Melitta; Hartman, Jodi F.; Wright, Michelle L.

doi:10.1097/01.asw.0000323532.98003.26

Cited by 62 publications

(49 citation statements)

References 8 publications

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“…The allografts are harvested from screened donors, and each is prepared with proprietary processes to decellularize and cryopreserve the dermis while maintaining the natural structure of the collagen and ECM. [240][241][242][243][244][245] As with the aforementioned ECM products, the dermal matrices serve as scaffolds for cellular repopulation and angiogenesis, with varying degrees of incorporation into the recipient wound bed. 246,247 One of these cryopreserved dermal allografts, referred to as a human skin allograft, claims that both the extracellular and cellular components are preserved during the minimal processing.…”

Section: Biological and Bioengineered Therapiesmentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,712

1,429

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Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg ulcers, and pressure ulcers. They are a challenge to wound care professionals and consume a great deal of healthcare resources around the globe. This review discusses the pathophysiology of complex chronic wounds and the means and modalities currently available to achieve healing in such patients.Recent Advances: Although often difficult to treat, an understanding of the underlying pathophysiology and specific attention toward managing these perturbations can often lead to successful healing.Critical Issues: Overcoming the factors that contribute to delayed healing are key components of a comprehensive approach to wound care and present the primary challenges to the treatment of chronic wounds. When wounds fail to achieve sufficient healing after 4 weeks of standard care, reassessment of underlying pathology and consideration of the need for advanced therapeutic agents should be undertaken. However, selection of an appropriate therapy is often not evidence based.Future Directions: Basic tenets of care need to be routinely followed, and a systematic evaluation of patients and their wounds will also facilitate appropriate care. Underlying pathologies, which result in the failure of these wounds to heal, differ among various types of chronic wounds. A better understanding of the differences between various types of chronic wounds at the molecular and cellular levels should improve our treatment approaches, leading to better healing rates, and facilitate the development of new more effective therapies. More evidence for the efficacy of current and future advanced wound therapies is required for their appropriate use.

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Section: Biological and Bioengineered Therapiesmentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,712

1,429

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“…TERM approach using acellular dermal graft has also been described [31]. This technique allies tissue-engineered matrices to the cells and GFs present in the human recipient following transplantation.…”

Section: Introduction: Fundamentals Of Tissue Engineering and Regenermentioning

confidence: 99%

Current concepts: tissue engineering and regenerative medicine applications in the ankle joint

Correia

Pereira

Silva‐Correia

et al. 2014

J. R. Soc. Interface.

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Tissue engineering and regenerative medicine (TERM) has caused a revolution in present and future trends of medicine and surgery. In different tissues, advanced TERM approaches bring new therapeutic possibilities in general population as well as in young patients and high-level athletes, improving restoration of biological functions and rehabilitation. The mainstream components required to obtain a functional regeneration of tissues may include biodegradable scaffolds, drugs or growth factors and different cell types (either autologous or heterologous) that can be cultured in bioreactor systems (in vitro) prior to implantation into the patient. Particularly in the ankle, which is subject to many different injuries (e.g. acute, chronic, traumatic and degenerative), there is still no definitive and feasible answer to 'conventional' methods. This review aims to provide current concepts of TERM applications to ankle injuries under preclinical and/or clinical research applied to skin, tendon, bone and cartilage problems. A particular attention has been given to biomaterial design and scaffold processing with potential use in osteochondral ankle lesions.

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“…No RCTs exist for any other indications aside from DFU. Studies have shown a statistically signifi cant higher percentage of overall wound healing with the use of Graftjacket ( Brigido, 2006 ;Brigido, Boc, & Lopez, 2004 ;Martin, Sangalang, Wu, & Armstrong, 2005 ;Reyzelman et al, 2009 ;Winters et al, 2008 ).…”

Section: Reconstruction Departmentmentioning

confidence: 97%