A multicenter report of the use of plasma rich in growth factors (PRGF) for the treatment of patients with ocular surface diseases in North America

Soifer, Matias; Tovar, Arianna; Wang, Margaret; Mousa, Hazem M.; Yennam, Sowmya; Sabater, Alfonso L.; Pflugfelder, Stephen C.; Pérez, Víctor L.

doi:10.1016/j.jtos.2022.04.007

Cited by 15 publications

(7 citation statements)

References 39 publications

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“…However, they are ineffective in the protection or recovery of the impaired corneal innervation [ 57 , 58 ]. Alternative topical methods, including autologous plasma rich in growth factors (PRGF ® ; BTI, Vitoria, Spain) [ 59 , 60 , 61 ], and synthetic heparan sulfate mimetic polymers (RGTA Cacicol ® ; Théa Laboratoires, Clermont-Ferrand, France) [ 62 , 63 ] have been shown to improve ocular surface wound healing and nerve regeneration in animal models. Antioxidants have been assayed in the ocular surface as anti-inflammatory therapy [ 24 ] and for the treatment of DED [ 64 ] but, to date, no treatment has focused specifically on the neuroprotection of sensory corneal innervation.…”

Section: Discussionmentioning

confidence: 99%

Immunocytochemical Analysis of Crocin against Oxidative Stress in Trigeminal Sensory Neurons Innervating the Cornea

Sánchez-Fernández,

Del Olmo-Aguado,

Artime

et al. 2024

Molecules

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Corneal diseases are a major cause of vision loss, often associated with aging, trauma and disease. Damage to corneal sensory innervation leads to discomfort and pain. Environmental stressors, such as short-wavelength light, can induce oxidative stress that alters mitochondrial function and affects cell and tissue homeostasis, including corneal innervation. Cellular antioxidant mechanisms may attenuate oxidative stress. This study investigates crocin, a derivative of saffron, as a potential antioxidant therapy. In vitro rat trigeminal sensory ganglion neurons were exposed to both sodium azide and blue light overexposure as a model of oxidative damage. Crocin was used as a neuroprotective agent. Mitochondrial and cytoskeletal markers were studied by immunofluorescence analysis to determine oxidative damage and neuroprotection. In vivo corneal innervation degeneration was evaluated in cornea whole mount preparations using Sholl analyses. Blue light exposure induces oxidative stress that affects trigeminal neuron mitochondria and alters sensory axon dynamics in vitro, and it also affects corneal sensory innervation in an in vivo model. Our results show that crocin was effective in preserving mitochondrial function and protecting corneal sensory neurons from oxidative stress. Crocin appears to be a promising candidate for the neuroprotection of corneal innervation.

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Section: Discussionmentioning

confidence: 99%

Immunocytochemical Analysis of Crocin against Oxidative Stress in Trigeminal Sensory Neurons Innervating the Cornea

Sánchez-Fernández,

Del Olmo-Aguado,

Artime

et al. 2024

Molecules

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“…These eye drops are similar to ASTs but contain higher concentrations of platelet-derived factors, such as epidermal growth factor (EGF), transforming growth factor beta (TGF-b), insulin-like growth factor 1 (IGF-1), and platelet-derived growth factor (PDGF). 34 In vitro studies using pure PRP have indicated that some of its constituents such as IGF-1 and PDGF are the main peptides involved in Schwann cell proliferation and migration promoting peripheral nerve regeneration. 35 Further research is required for evaluating the effect of PRP and PRGF in individuals with NOP.…”

Section: Plasma Rich In Growth Factorsmentioning

confidence: 99%

Novel Treatments for Chronic Ocular Surface Pain

Mangwani-Mordani

Goodman

2022

Cornea

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:Several etiologies can contribute to ocular surface pain including nociceptive, peripheral neuropathic, and central neuropathic mechanisms. Clinical clues can help identify contributors to ocular surface pain in a patient. In individuals whose pain persists despite targeting nociceptive contributors, neuropathic mechanisms should be considered and addressed using oral, topical, and/or adjuvant agents.

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“…[5][6][7] Thus, mild topical steroids, punctal occlusion, use of therapeutic contact lenses, autologous serum tears, platelet rich in growth factors, drops or membranes, compounded insulin drops, and corneal scraping with amniotic membrane transplantation are often used. 8,9 By contrast, for total LSCD, a limbal stem cell transplantation (LSCT) is warranted. The origin of the limbal stem cells can be either autologous from the unaffected eye or allogeneic from a living-related or cadaveric donor.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Combined Penetrating Keratoplasty and Limbal Stem Cell Transplantation: A Meta-Analysis on Simultaneous Versus Sequential Surgery

Giachos

Angelidis

Doumazos

et al. 2023

Cornea

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The objective of this study is to perform a systematic review and meta-analysis of the published studies on limbal stem cell transplantation (LSCT) combined with penetrating keratoplasty (PK) performed either simultaneously or sequentially.Methods: An extensive search was conducted in the MEDLINE and Google Scholar databases. Prospective and retrospective trials and case series reporting on the outcomes of LSCT with PK were included. Primary outcomes were the stability of the ocular surface and the rejection and/or failure of the corneal graft.Results: A total of 209 eyes from 13 studies were included in the simultaneous group and 489 eyes from 33 studies in the sequential group. Ocular surface stability was 88% [95% confidence interval (CI), 79%-96%] for sequential cases and 64% (95% CI, 43%-82%) for simultaneous cases (P = 0.001). The graft failure rate was 15% (95% CI, 6%-26%) for sequential cases and 44% (95% CI, 31%-58%) for simultaneous cases (P , 0.001). For cases performed sequentially, subgroup analysis revealed a stable ocular surface in 97% (95% CI, 91%-100%) of autograft cases and 63% (95% CI, 45%-80%) of allograft cases (P , 0.001). The graft failure rate in sequential cases was 7% (95% CI, 0%-18%) for autografts and 34% (95% CI, 18%-52%) for allografts (P , 0.001).Conclusions: Sequential LSCT followed by PK demonstrated superior results in terms of ocular surface stability and graft retention compared with simultaneous LSCT and PK. Limbal stem cells of autologous origin fare better than allogeneic ones in sequential cases.

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A multicenter report of the use of plasma rich in growth factors (PRGF) for the treatment of patients with ocular surface diseases in North America

Cited by 15 publications

References 39 publications

Immunocytochemical Analysis of Crocin against Oxidative Stress in Trigeminal Sensory Neurons Innervating the Cornea

Immunocytochemical Analysis of Crocin against Oxidative Stress in Trigeminal Sensory Neurons Innervating the Cornea

Novel Treatments for Chronic Ocular Surface Pain

Outcomes of Combined Penetrating Keratoplasty and Limbal Stem Cell Transplantation: A Meta-Analysis on Simultaneous Versus Sequential Surgery

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