A multicenter, randomized, open‐label comparative study of prabotulinumtoxinA with two different dosages and diverse proportional injection styles for the reduction of gastrocnemius muscle hypertrophy in Asian women

Abstract

A botulinum toxin (BTX) injection can be a simple and safe alternative to calf reduction surgery or liposuction without interrupting daily life. However, its optimum dosage and clinical response are not yet well known. A total of 40 patients with bilateral gastrocnemius muscle hypertrophy were enrolled in this study. All volunteers were randomly categorized into four groups and then administered different amounts of BTX (160 U and 200 U) on the medial and lateral aspects of their calves. All subjects showed clinical improvement with a reduction in the gastrocnemius muscle size after BTX injection. However, our results showed that the decrease in leg circumference was not dose dependent. No side effects of the injections, such as weakness of the legs, deformity, or abnormal sensation, were observed. There were also no cases of swelling, edema, hematoma, or infection. BTX at both dosages can be safely and effectively applied for calf muscle contouring without disturbing gait during walking or running.

Ultrasonographic analysis of the calves for efficient botulinum toxin type A injection

“…Another study hypothesized that solely paralyzing gastrocnemius muscle resulted in compensatory soleus muscle hypertrophy as calf circumference decrease was not dose-dependent. 17…”

“…Cheng et al 16 recommended injection to the lower soleus muscle if there is prominent soleus near the Achilles tendon. Another study hypothesized that solely paralyzing gastrocnemius muscle resulted in compensatory soleus muscle hypertrophy as calf circumference decrease was not dose‐dependent 17 . However, BoNT‐A injection into both gastrocnemius muscle and soleus muscle had the risk of reducing the viscoelastic properties of the Achilles tendons, though this was concluded from an animal study and has not been proved in humans 18 …”

The Efficacy of Botulinum Toxin A Injection for Gastrocnemius Hypertrophy: A Prospective, Randomized, Double-blinded Controlled Trial

“…Some studies on the effects and advantages of BTX-A injection for the correction of gastrocnemius muscle hypertrophy as a noninvasive treatment. [6][7][8][9][10][11][12][13][14] However, there was no prospective, randomized control study to prove the effectiveness of BTX-A injection for correction of lower leg contour.…”

Efficacy and safety of botulinum toxin injection in reducing deltoid muscle hypertrophy

“…Growing demand for safer and less painful procedures for achieving slim body contour has led to the development of several noninvasive modalities including botulinum toxin type A (BTX-A). [1][2][3][4][5][6] To the best of our knowledge, no clinical study has been conducted to assess the aesthetic effect of BTX-A on deltoid muscle hypertrophy. Therefore, we conducted a pilot study to determine the efficacy and safety of intramuscular BTX-A injection in reducing deltoid muscle hypertrophy in Asian women.…”

“…Conventional treatment options including liposuction and surgical resection, are associated with high procedure‐related complications such as muscular dystrophy or scarring. Growing demand for safer and less painful procedures for achieving slim body contour has led to the development of several noninvasive modalities including botulinum toxin type A (BTX‐A) 1–6 . To the best of our knowledge, no clinical study has been conducted to assess the aesthetic effect of BTX‐A on deltoid muscle hypertrophy.…”