A Multicenter Prospective Validation Study for the Korean Thyroid Imaging Reporting and Data System in Patients with Thyroid Nodules

Ha, Eun Ju; Moon, Won-Jin; Na, Dong Gyu; Lee, Young Hen; Choi, Nami; Kim, Soo Jin; Kim, Tae Yong

doi:10.3348/kjr.2016.17.5.811

Cited by 76 publications

(87 citation statements)

References 29 publications

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“…The specificity of this study was only 7.07% which was also lower compared to other studies (29%-75%). 8,[22][23][24] In our study, the prevalence of malignancy was higher at 33.56% compared to an FNAB based series wherein malignancy rate was only 3 to 7%. 7 With this, PPV/NPV might be affected since an increase in prevalence leads to increase in PPV.…”

Section: )mentioning

confidence: 74%

“…[8][9][10][21][22][23][24] The histopathology report of the patient who had a malignant result showed follicular carcinoma on top of a micropapillary carcinoma. One patient who also had TIRADS 3 had an incidental finding of micropapillary carcinoma measuring 0.5 cm within the left lobe but the FNAB was done on another nodule that The accuracy of TIRADS in our study was 53% which was slightly lower as compared to the studies of Ha et al, at 69.5% 22 and Russ et al, at 62%. 25 The reason for low accuracy is possibly because of a high false positive rate.…”

Section: )mentioning

confidence: 99%

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Thyroid Imaging Reporting and Data System (TIRADS) in Stratifying Risk of Thyroid Malignancy at The Medical City

Dy¹,

Kasala²,

Yao³

et al. 2017

JAFES

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Objective. To determine the accuracy of Thyroid Imaging Reporting and Data System (TIRADS) in detecting thyroid malignancy, determine risk of malignancy in each TIRADS category and determine the ultrasound characteristics associated with malignancy.Methodology. This is a retrospective cross-sectional study involving patients who underwent ultrasound, thyroid fine needle aspiration biopsy (FNAB) and thyroidectomy at The Medical City from January 2014 to December 2015. Ultrasound reports were retrieved and reviewed by two radiologists on separate occasions who were blinded to the cytopathology and histopathology results. The histopathology reports were correlated with ultrasound features to determine features associated with malignancy. Stata SE 12 was used for data analysis. TIRADS sensitivity, specificity, positive predictive values and negative predictive values and accuracy were calculated.Results. 149 patients with thyroid nodules were included. Solid composition is the ultrasound feature predictive of malignancy with adjusted OR 4.912 (95% Cl 1.3257 to 18.2011, p=0.017). The risk of malignancy for TIRADS categories 3, 4a, 4b, 4c and 5 were 12.50%, 12.82%, 26.19%, 53.70% and 66.67%, respectively. The Crude OR (95% CI) for TIRADS 4a, 4b, 4c and 5 were 1.03 (0.10 to 10.23), 2.48 (0.27 to 22.54), 8.12 (0.93 to 70.59) and 14.0 (0.94 to 207.60), respectively. The sensitivity, specificity, PPV, NPV and accuracy of TIRADS in relation to surgical histopathology report were 98.00%, 7.07%, 34.75%, 87.50%, and 53% respectively in TIRADS categories 4 and 5.Conclusion. This study showed that a solid nodule is the most frequent ultrasound feature predictive of thyroid malignancy. Higher TIRADS classification is associated with higher risk of thyroid malignancy. TIRADS is a sensitive classification in recognizing patients with thyroid cancer.

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confidence: 74%

Section: )mentioning

confidence: 99%

Thyroid Imaging Reporting and Data System (TIRADS) in Stratifying Risk of Thyroid Malignancy at The Medical City

Dy¹,

Kasala²,

Yao³

et al. 2017

JAFES

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“…These tumors have been diagnosed as high- or intermediatesuspicion nodules using US based on the Korean Thyroid Image Reporting and Data System [23,24]. Some tumors have been reported to have a well-defined border and could be predicted to exhibit indolent behavior [25].…”

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confidence: 99%

Ultrasonographic imaging of papillary thyroid carcinoma variants

Shin

2017

Ultrasonography

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Ultrasonography (US) is routinely used to evaluate thyroid nodules. The US features of papillary thyroid carcinoma (PTC), the most common thyroid malignancy, include hypoechogenicity, spiculated/microlobulated margins, microcalcifications, and a nonparallel orientation. However, many PTC variants have been identified, some of which differ from the classic type of PTC in terms of biological behavior and clinical outcomes. This review describes the US features and clinical implications of the variants of PTC. With the introduction of active surveillance replacing immediate biopsy or surgical treatment of indolent, small PTCs, an understanding of the US characteristics of PTC variants will facilitate the individualized management of patients with PTC.

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“…Conventional US can be used to detect nodules, and it also provides information on the composition, size, and number of nodules, as well as their anatomical relationships with surrounding structures. US findings that have been reported to be suggestive of malignant thyroid nodules include solid composition, hypoechogenicity or marked hypoechogenicity, a microlobulated or irregular margin, mixed calcification or microcalcifications, and a taller-than-wide shape [1,2]. However, a considerable number of US findings overlap between benign and malignant thyroid nodules, making it difficult to identify thyroid malignancies based on US imaging alone [3,4].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Performance of a Combination of Shear Wave Elastography and B-Mode Ultrasonography in Differentiating Benign From Malignant Thyroid Nodules

Yeon

Sohn

Seo

et al. 2020

Clin Exp Otorhinolaryngol

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Objectives. This study was conducted to compare clinicopathologic and radiologic factors between benign and malignant thyroid nodules and to evaluate the diagnostic performance of shear wave elastography (SWE) combined with Bmode ultrasonography (US) in differentiating malignant from benign thyroid nodules.Methods. This retrospective study included 92 consecutive patients with 95 thyroid nodules examined on B-mode US and SWE before US-guided fine-needle aspiration biopsy or surgical excision. B-mode US findings (composition, echogenicity, margin, shape, and calcification) and SWE elasticity parameters (maximum [Emax], mean, minimum, and nodule-to-normal parenchymal ratio of elasticity) were reviewed and compared between benign and malignant thyroid nodules. The diagnostic performance of B-mode US and SWE for predicting malignant thyroid nodules was analyzed. The optimal cutoff values of elasticity parameters for identifying malignancy were determined. Diagnostic performance was compared between B-mode US only, SWE only, and the combination of B-mode US with SWE.Results. On multivariate logistic regression analysis, age (odds ratio [OR], 0.90; P =0.028), a taller-than-wide shape (OR, 11.3; P =0.040), the presence of calcifications (OR, 15.0; P =0.021), and Emax (OR, 1.22; P =0.021) were independent predictors of malignancy in thyroid nodules. The combined use of B-mode US findings and SWE yielded improvements in sensitivity, the positive predictive value, the negative predictive value, and accuracy compared with the use of B-mode US findings only, but with no statistical significance.

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A Multicenter Prospective Validation Study for the Korean Thyroid Imaging Reporting and Data System in Patients with Thyroid Nodules

Cited by 76 publications

References 29 publications

Thyroid Imaging Reporting and Data System (TIRADS) in Stratifying Risk of Thyroid Malignancy at The Medical City

Thyroid Imaging Reporting and Data System (TIRADS) in Stratifying Risk of Thyroid Malignancy at The Medical City

Ultrasonographic imaging of papillary thyroid carcinoma variants

Diagnostic Performance of a Combination of Shear Wave Elastography and B-Mode Ultrasonography in Differentiating Benign From Malignant Thyroid Nodules

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