A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma: A Protocol Design

Valiente-Gómez, Alicia; Pujol, Núria; Moreno‐Alcázar, Ana; Raduà, Joaquim; Monteagudo-Gimeno, Eila; Gardoki-Souto, Itxaso; Hogg, Bridget; Álvarez, María José Pérez; Safont, Gemma; Lupo, Walter; Pérez, Ví­ctor; Amann, Benedikt L.

doi:10.3389/fpsyt.2019.01023

Cited by 5 publications

(3 citation statements)

References 56 publications

(54 reference statements)

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“…There is also emerging evidence in support of its transdiagnostic efficacy for reducing co-occurring depression and anxiety symptoms (Goldbeck et al, 2016; Lenz and Hollenbaugh, 2017); though these findings are not conclusive (De Arellano et al, 2014). Future research should address these inconsistencies and the dearth of evidence across other symptoms domains, such as early psychosis and early mania, although such work has begun (Tong et al, 2018; Valiente-Gomez et al, 2020). In addition to therapeutic intervention, large-scale child abuse and neglect prevention programmes and greater support for the child protection system are needed.…”

Section: Discussionmentioning

confidence: 99%

Childhood trauma is prevalent and associated with co-occurring depression, anxiety, mania and psychosis in young people attending Australian youth mental health services

Bendall

Eastwood

Spelman

et al. 2023

Aust N Z J Psychiatry

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Objectives: Childhood trauma is common and associated with mental ill health. While high rates of trauma are observed across individual disorders, there is evidence that trauma is associated with an admixture of affective, anxiety and psychotic symptoms in adults. Given that early onset of mental disorder and trauma exposure herald poor outcomes, it is important to examine trauma prevalence rates in youth mental health services and to determine whether this trauma-related clustering is present in help-seeking young people. Methods: We used data from the Transitions Study, a longitudinal investigation of young people attending headspace youth mental health services in Australia between January 2011 and August 2012. Participants were 775 young people aged 12–25. Childhood trauma was assessed using the Childhood Trauma Questionnaire. Multinomial regression was used to assess whether reported childhood trauma was more strongly associated with the co-occurrence of depression, anxiety, mania and psychosis symptoms than with any one in isolation. Results: Approximately 84% of participants reported some form of abuse (emotional: 68%; physical: 32%; sexual: 22%) or neglect (emotional: 65%; physical: 46%). Exposure to multiple trauma types was common. Childhood trauma was significantly associated with each symptom domain. More severe childhood trauma was more strongly associated with the co-occurrence of symptoms than with any one symptom domain in isolation, such that more severely trauma-exposed young people were more likely to experience increased symptom clustering. Conclusions: Childhood trauma is pervasive in youth mental health services and associated with a symptom profile that cuts across traditional diagnostic boundaries.

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Section: Discussionmentioning

confidence: 99%

Childhood trauma is prevalent and associated with co-occurring depression, anxiety, mania and psychosis in young people attending Australian youth mental health services

Bendall

Eastwood

Spelman

et al. 2023

Aust N Z J Psychiatry

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“…Most pressingly, more high‐quality research is needed, specifically with psychotic symptoms as a primary outcome and on patients with trauma histories. We look forward to the findings of controlled research which is underway (Peters, 2020 ; Valiente‐Gómez et al., 2020 ). Future research will benefit from a standardisation of the measure used for psychotic symptoms to enable direct comparison between studies; there have been recent (albeit controversial) movements to do so for non‐psychotic measures (The Lancet Psychiatry, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The effectiveness and tolerability of trauma‐focused psychotherapies for psychotic symptoms: A systematic review of trauma‐focused psychotherapies

Reid,

Cole,

Malik

et al. 2024

Int J Methods Psych Res

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IntroductionPsychological trauma is an established risk factor for psychosis. Trauma‐focused psychotherapies (TFPT) have been suggested as a potential treatment for reducing psychotic symptoms in those who have experienced trauma. We therefore sought to investigate the effectiveness, tolerability, and acceptability of TFPT for psychotic symptoms.MethodsWe conducted a systematic review of studies of any form of TFPT that measured psychotic symptoms across a broad range of diagnoses.ResultsFrom 2584 papers initially identified, 17 studies (857 participants) met eligibility criteria. TFPT were found to be well tolerated, with very few adverse events. Acceptability was also high, with a mean dropout rate of 20%.ConclusionsWhilst the evidence of effectiveness for TFPT in reducing psychotic symptoms is weak, we found tentative evidence in favour of exposure‐based interventions. Methodologically rigorous trials investigating the efficacy of TFPT for the treatment of psychotic symptoms are needed to assess this promising intervention.

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“…There is also emerging evidence in support of its transdiagnostic efficacy for reducing co-occurring depression and anxiety symptoms (Goldbeck et al, 2016; Lenz and Hollenbaugh, 2017); though these findings are not conclusive (de Arellano et al, 2014). Future research should address these inconsistencies and the dearth of evidence across other symptoms domains, such as early psychosis and early mania, although such work has begun (Tong et al, 2018; Valiente-Gomez et al, 2020). In addition to therapeutic intervention, large scale child abuse and neglect prevention programs and greater support for the child protection system are needed.…”

Section: Discussionmentioning

confidence: 99%

Childhood trauma is prevalent and associated with co-occurring depression, anxiety, mania and psychosis in young people attending Australian youth mental health services

Bendall

Eastwood

Spelman

et al. 2023

Preprint

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Objectives: Childhood trauma is common and associated with mental ill health. While high rates of trauma are observed across individual disorder groups, there is evidence that trauma is associated with an admixture of affective, anxiety, and psychotic symptoms in adults. Given that both early onset of mental disorder and trauma exposure herald poor outcomes, it is important to examine trauma prevalence rates in youth mental health services and to determine whether this trauma-related clustering is present in help-seeking young people. Methods: We used data from the Transitions Study, a longitudinal investigation of young people attending one of four headspace youth mental health services in Melbourne and Sydney, Australia between January 2011 and August 2012. Participants were 775 young people aged 12 to 25 (65.9% female; mean age = 18.3, SD = 3.2). Childhood trauma was assessed using the Childhood Trauma Questionnaire (CTQ). Multinomial regression was used to assess whether reported childhood trauma was more strongly associated with the co-occurrence of depression, anxiety, mania, and psychosis symptoms than with any one in isolation. Results: Approximately 84% of participants reported some form of abuse (emotional: 68%; physical: 32%; sexual: 22%) or neglect (emotional: 65%; physical: 46%) during childhood or adolescence. Exposure to multiple trauma types was common. Childhood trauma was significantly associated with each symptom domain (depression, mania, anxiety and psychosis). Childhood trauma was more strongly associated with the co-occurrence of these symptoms than with any one of these domains in isolation, such that trauma-exposed young people were more likely to experience increased symptom clustering than their non-exposed counterparts. Conclusions: Childhood trauma is pervasive in youth mental health services and associated with a heterogeneous symptom profile that cuts across traditional diagnostic boundaries.

show abstract

A Multicenter Phase II RCT to Compare the Effectiveness of EMDR Versus TAU in Patients With a First-Episode Psychosis and Psychological Trauma: A Protocol Design

Cited by 5 publications

References 56 publications

Childhood trauma is prevalent and associated with co-occurring depression, anxiety, mania and psychosis in young people attending Australian youth mental health services

Childhood trauma is prevalent and associated with co-occurring depression, anxiety, mania and psychosis in young people attending Australian youth mental health services

The effectiveness and tolerability of trauma‐focused psychotherapies for psychotic symptoms: A systematic review of trauma‐focused psychotherapies

Childhood trauma is prevalent and associated with co-occurring depression, anxiety, mania and psychosis in young people attending Australian youth mental health services

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