A multicenter, phase I evaluation of cryopreserved venous valve allografts for the treatment of chronic deep venous insufficiency

Dalsing, Michael C.; Raju, Seshadri; Wakefield, Thomas W.; Taheri, Syde A.

doi:10.1016/s0741-5214(99)70010-8

Cited by 47 publications

(29 citation statements)

References 33 publications

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“…The specific reasons for the location of ulcerations in these sites is uncertain, but presumably due to some specifics of the anatomy of the venous system and its relationship to the tissue locations involved. Surgical techniques have focused on correction of the abnormal hemodynamics by repair, reconstruction, or transplantation of the venous valvular system (8,11,16,27,28,(30)(31)(32). Reconstruction with free tissue transfer has shown variable success.…”

Section: Introductionmentioning

confidence: 99%

Valvular Density Alone Cannot Account for Sites of Chronic Venous Insufficiency and Ulceration in the Lower Extremity

et al. 2001

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This study shows that the density of venous valves is actually higher in regions of the human lower extremity overlying bones and tendons, where venous stasis ulcers are common, than those overlying muscular areas, where ulcers are rarely seen. Thus, valvular quantity alone cannot account for the higher clinical incidence of ulceration. It is likely that muscular pumping and/or valvular quality are important factors in preventing the development of venous stasis and ulceration in the lower extremity.

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Section: Introductionmentioning

confidence: 99%

Valvular Density Alone Cannot Account for Sites of Chronic Venous Insufficiency and Ulceration in the Lower Extremity

et al. 2001

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“…48 The study consisted of nine patients having a single valve transplant placed distally to all lower extremity venous reflux.4s In a second trial, an approximately 50% competency rate was reported at 1 year.49 No long-term follow-up is currently available.…”

Section: Experimental Venous Valve Substitutesmentioning

confidence: 99%

Deep Vein Valvular Incompetence: Options for Reconstruction

Sanders¹,

Dalsing²

2001

Perspectives in Vascular Surgery and Endovascular Therapy

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Some degree of lower limb chronic venous insufficiency (CVI) affects over 30 million Americans. Varicosities have been recognized since 1500 B.C.; however, an accurate diagnosis of the variety of lower limb venous diseases and their treatment has made steady headway only in the recent past. Superficial and perforator insufficiency can be eliminated by a multitude of extirpative techniques. CVI due to advanced deep venous abnormalities is more problematic. Surgical intervention has become an option for end-stage patients who have failed conservative medical therapy Direct in situ valve repairs are possible by a variety of methods. Secondary causes of valve damage can be corrected by transposition or transplant techniques. Many of these deep venous reconstructions can be supported by long-term data not available even 20 years ago. A quest for valve substitutes for patients with no native valves available for transplantation continues. Yet long-term follow-up with a precise gradation of improvement in signs, symptoms, and diagnostic studies is essential for continued growth in the field of deep venous reconstructions.

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“…47 A recent phase I clinical trial of cryopreserved human allograft venous valves reported a 67% primary graft patency and 56% competency rate at 6 months. 48 The study consisted of nine patients having a single valve transplant placed distally to all lower extremity venous reflux. 48 In a second trial, an approximately 50% competency rate was reported at 1 year.…”

Section: Experimental Venous Valve Substitutesmentioning

confidence: 99%

“…48 The study consisted of nine patients having a single valve transplant placed distally to all lower extremity venous reflux. 48 In a second trial, an approximately 50% competency rate was reported at 1 year. 49 No long-term follow-up is currently available.…”

Section: Experimental Venous Valve Substitutesmentioning

confidence: 99%

Deep Vein Valvular Incompetence: Options for Reconstruction

Sanders¹,

Dalsing²

2001

Perspectives in Vascular Surgery

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A multicenter, phase I evaluation of cryopreserved venous valve allografts for the treatment of chronic deep venous insufficiency

Abstract: In patients with few remaining therapeutic options, one can achieve a 6-month assisted patency and competency rate of 78% and 67%, respectively, with an improved clinical outcome.

Cited by 47 publications

References 33 publications

Valvular Density Alone Cannot Account for Sites of Chronic Venous Insufficiency and Ulceration in the Lower Extremity

Valvular Density Alone Cannot Account for Sites of Chronic Venous Insufficiency and Ulceration in the Lower Extremity

Deep Vein Valvular Incompetence: Options for Reconstruction

Deep Vein Valvular Incompetence: Options for Reconstruction

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