A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women

Zhang, Xi; Lin, Xi; Tan, Yanlin; Zhu, Ying; Wang, Hui; Feng, Rui; Tang, Guoxue; Zhou, Xiang; Liu, Lixian; Qiao, You‐Lin

doi:10.21147/j.issn.1000-9604.2018.02.06

Cited by 21 publications

(18 citation statements)

References 29 publications

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“…We then screened titles and abstracts to exclude 322 articles that did not meet the inclusion criteria or that met the exclusion criteria. We completely evaluated the remaining 82 articles, among which 17 (12 in English, 5 in Chinese) (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) were selected for diagnostic accuracy analysis and 13 (11 in English, 2 in Chinese) (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) were selected for detection rate analysis (Figure 1). Because 8 articles were used for both diagnostic accuracy and detection rate, a total of 22 articles (13-34) were included in this study (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Diagnostic value of an automated breast volume scanner compared with a hand-held ultrasound: a meta-analysis

Zhang¹,

Chen²,

Zhou³

et al. 2019

Gland Surg

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Background: The diagnostic performance of an automated breast volume scanner (ABVS) compared with that of a hand-held ultrasound (HHUS) for breast cancer remains unclear. We performed a meta-analysis to compare the diagnostic performances of the ABVS and HHUS for breast cancer.Methods: We searched PubMed, EMBASE, Cochrane, and SinoMed databases to identify eligible studies up until November 14, 2018. Studies comparing ABVS and HHUS for differentiating benign and malignant breast tumors were included. A meta-analysis was performed to generate pooled diagnostic accuracy parameters [sensitivity, specificity, diagnostic odds ratio (DOR), area under the curve (AUC), and the Q* index] and detection rates for ABVS and HHUS.Results: Nine studies involving 1,376 patients and 1,527 lesions were included in the meta-analysis for diagnostic accuracy. The pooled sensitivity was 0.93 [95% confidence interval (CI), 0.91-0.95] for ABVS and 0.90 (95% CI, 0.88-0.92) for HHUS, and the pooled specificity was 0.86 (95% CI, 0.83-0.88) for ABVS and 0.82 (95% CI, 0.79-0.84) for HHUS. The pooled DOR was 88.66 (95% CI, 51.44-152.78) for ABVS and 41.06 for HHUS (95% CI, 26.58-63.42). The AUC of the summary receiver operating characteristic (SROC) was 0.9496 for ABVS and 0.9143 for HHUS, and the Q* index was 0.8899 for ABVS and 0.8469 for HHUS.Meta-regression showed no significant difference between the diagnostic accuracy of ABVS and HHUS (P=0.0771). No publication bias was found. Thirteen published studies involving 1,047 pathologically confirmed malignant lesions were included to generate a pooled detection rate. The pooled detection rate was 1.00 (95% CI, 1.00-1.00) for both ABVS and HHUS, for which a publication bias was found.Conclusions: ABVS can be used as an appropriate screening tool for breast cancer as well as HHUS in diagnostic accuracy and detection rate. Considering other advantages of ABVS including non-radioactivity, sensitivity to dense breast, three-dimensional reconstruction, time-saving and repeatability, it might be a promising screening tool for young or dense-breast women in the future.

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Section: Resultsmentioning

confidence: 99%

Diagnostic value of an automated breast volume scanner compared with a hand-held ultrasound: a meta-analysis

Zhang¹,

Chen²,

Zhou³

et al. 2019

Gland Surg

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Section: Clinical Practicementioning

confidence: 99%

“…More recently, Zhang et al [35] demonstrated a better diagnostic performance of ABUS versus HHUS, in particular in the detection of precancerous lesions or cancers (BIRADS 4-5). In this hospital-based multicentre diagnostic study, Zhang et al [35] have evaluated the clinical performance of the ABUS for breast cancer detection by comparing it to handheld ultrasound and mammography (MG) in 1973 women, from 30 to 69 years. The results not only shown a good diagnostic performance of ABUS but also that the ABUS results, compared to HHUS, were more consistent with the pathology results in the BIRADS 4-5 groups: 78.6% of women classified as BI-RADS 4-5 based on the ABUS were diagnosed with precancerous lesions or cancer, which was 7.2% higher than that of women based on HHUS.…”

Section: Clinical Practicementioning

confidence: 99%

Automatic breast ultrasound: state of the art and future perspectives

Nicosia¹,

Ferrari²,

Bozzini³

et al. 2020

ecancer

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The three-dimensional automated breast ultrasound system (3D ABUS) is a new device which represents a huge innovation in the breast ultrasound field, with several application scenarios of great interest. ABUS's aim is to solve some of the main defects of traditional ultrasound, such as lack of standardization, high level of skill non-reproducibility, small field of view and high commitment of physician time. ABUS has proven to be an excellent non-ionising alternative to other supplemental screening options for women with dense breast tissue; also, it has appeared to be very promising in daily clinical practice. The purpose of this paper is to present a summary of current applications of ABUS, focusing on clinical applications and future perspectives as ABUS is particularly promising for studies involving artificial intelligence, radiomics and evaluation of breast molecular subtypes.

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“…Studies have shown that in asymptomatic women with normal mammography but dense breasts ABUS is capable of detecting approximately two breast cancers per 1000 women tested 75 . A multicentric hospital-based cross-sectional study carried out in China in 2016 compared HHUS, ABUS and mammography in 1974 CBE-positive women aged 30-69 years 76 . The results suggest that ABUS has the comparable clinical performance to HHUS for breast cancer detection, and both traditional ultrasound and ABUS have better performance than mammography, especially among women with high-density breasts.…”

Section: Screening For Breast Cancermentioning

confidence: 99%

A pragmatic approach to tackle the rising burden of breast cancer through prevention & early detection in countries 'in transition'

Basu¹,

Zhang²,

Hariprasad³

et al. 2020

Indian J Med Res

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Among the emerging economies Brazil, Russia, India, China and South Africa (together known as the BRICS countries) share collectively approximately 40 per cent of the global population and contribute to 25 per cent of the world gross domestic products. All these countries are facing the formidable challenge of rising incidence of breast cancer and significant number of premature deaths from the disease. A multidimensional approach involving prevention, early detection and improved treatment is required to counteract the growing burden of breast cancer. A growing trend in the prevalence of major preventable risk factors of breast cancer such as obesity, western dietary habits, lack of physical activity, consumption of alcohol and smoking is contributing significantly to the rising burden of the disease in BRICS nations. Specific interventions are needed at the individual and population levels to mitigate these risk factors, preferably within the broader framework of non-communicable disease control programme. Population-based quality assured mammography-based screening of the 50-69 yr old women can reduce breast cancer mortality at least by 20 per cent. However, none of the BRICS countries have been able to implement population-based organized screening programme. Large scale opportunistic screening with mammography targeting predominantly the younger women is causing harms to the women and wasting precious healthcare resources. There are recent national recommendations to screen women with mammography in Brazil and Russia and with clinical breast examination in China (along with ultrasound) and India. Given the challenges of implementing systematic screening of the population, the BRICS countries should prioritize the early diagnosis approach and invest in educating the women about the breast cancer symptoms, training the frontline health providers to clinically detect breast cancers and appropriately refer for diagnostic confirmation, and creating improved access to good quality diagnostic and treatment facilities for breast cancer. The early diagnosis approach has been proved to achieve downstaging and improve survival at a fraction of the resources needed for population screening. The countries also need to focus on improving the services and capacity for multidisciplinary treatment of breast cancer, histopathology and immunohistochemistry, safe administration of chemotherapy and palliative care.

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A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women

Abstract: We observed a good diagnostic reliability for the ABUS. Considering its performance for breast cancer detection in women with high-density breasts and its lower operator dependence, the ABUS is a promising option for breast cancer detection in China.

Cited by 21 publications

References 29 publications

Diagnostic value of an automated breast volume scanner compared with a hand-held ultrasound: a meta-analysis

Diagnostic value of an automated breast volume scanner compared with a hand-held ultrasound: a meta-analysis

Automatic breast ultrasound: state of the art and future perspectives

A pragmatic approach to tackle the rising burden of breast cancer through prevention & early detection in countries 'in transition'

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